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Enhanced therapeutic efficacy of Dioscorea cirrhosa Lour. n-butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects.

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Τίτλος: Enhanced therapeutic efficacy of Dioscorea cirrhosa Lour. n-butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects.
Συγγραφείς: Wang M; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Peng X; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Yang C; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Yu X; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Tai H; College of Dai Medicine, West Yunnan University of Applied Sciences, Xishuangbanna, China., Li Y; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Πηγή: Natural product research [Nat Prod Res] 2026 Sep; Vol. 40 (18), pp. 5711-5721. Date of Electronic Publication: 2025 Aug 07.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
Ιατρικοί όροι (MeSH): Dioscorea*/chemistry , Colitis, Ulcerative*/drug therapy , Colitis, Ulcerative*/chemically induced , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , 1-Butanol*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, Intestinal Mucosa/drug effects ; Cytokines/metabolism ; Animals ; Male ; Mice ; Dextran Sulfate
Περίληψη: This study systematically evaluated the intestinal mucosal protective effects of Dioscorea cirrhosa Lour. tuber's n-butanol fraction (rich in condensed tannins) against DSS-induced colitis using dual intragastric and enema administration. Analytical approaches included Disease Activity Index (DAI), haematoxylin and eosin (HE) staining, Alcian blue-periodic acid Schiff (AB-PAS) staining, ELISA, immunohistochemistry, immunofluorescence, and Western blot. LC-MS/MS identified the chemical constituents. Administering the DC n-butanol fractions through both routes significantly alleviated colitis symptoms (p < 0.05), including weight loss, and colon shortening. Histological analysis revealed reduced epithelial damage, decreased inflammatory cell infiltration, and increased goblet cell numbers with enhanced mucus production. Pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were markedly suppressed (p < 0.05). Furthermore, combined administration more effectively upregulated tight junction proteins (ZO-1, occludin, claudin-1) and MUC2 expression, thereby reinforcing intestinal mucosal barrier integrity. These findings highlight the therapeutic potential of D. cirrhosa fractions in ulcerative colitis management through dual anti-inflammatory and barrier-enhancing mechanisms.
Contributed Indexing: Keywords: Dioscorea cirrhosa Lour; LC-MS/MS; intestinal mucosal barrier; ulcerative colitis
Substance Nomenclature: 0 (Anti-Inflammatory Agents)
8PJ61P6TS3 (1-Butanol)
0 (Plant Extracts)
9042-14-2 (Dextran Sulfate)
0 (Cytokines)
Entry Date(s): Date Created: 20250807 Date Completed: 20260928 Latest Revision: 20260928
Update Code: 20260928
DOI: 10.1080/14786419.2025.2544320
PMID: 40771052
Βάση Δεδομένων: MEDLINE
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  Data: Enhanced therapeutic efficacy of Dioscorea cirrhosa Lour. n-butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+M%22&quot;&gt;Wang M&lt;/searchLink&gt;; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Peng+X%22&quot;&gt;Peng X&lt;/searchLink&gt;; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Yang+C%22&quot;&gt;Yang C&lt;/searchLink&gt;; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Yu+X%22&quot;&gt;Yu X&lt;/searchLink&gt;; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Tai+H%22&quot;&gt;Tai H&lt;/searchLink&gt;; College of Dai Medicine, West Yunnan University of Applied Sciences, Xishuangbanna, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Li+Y%22&quot;&gt;Li Y&lt;/searchLink&gt;; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101167924%22&quot;&gt;Natural product research&lt;/searchLink&gt; [Nat Prod Res] 2026 Sep; Vol. 40 (18), pp. 5711-5721. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2025 Aug 07.
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  Data: &lt;i&gt;Original Publication&lt;/i&gt;: Milton Park, UK : Taylor &amp; Francis Health Sciences, c2003-
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dioscorea%22&quot;&gt;Dioscorea*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dioscorea+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Colitis%2C+Ulcerative%22&quot;&gt;Colitis, Ulcerative*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Colitis%2C+Ulcerative+drug+therapy%22&quot;&gt;drug therapy&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Colitis%2C+Ulcerative%22&quot;&gt;Colitis, Ulcerative*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Colitis%2C+Ulcerative+chemically+induced%22&quot;&gt;chemically induced&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Anti-Inflammatory+Agents%22&quot;&gt;Anti-Inflammatory Agents*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Anti-Inflammatory+Agents+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Anti-Inflammatory+Agents%22&quot;&gt;Anti-Inflammatory Agents*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Anti-Inflammatory+Agents+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%221-Butanol%22&quot;&gt;1-Butanol*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%221-Butanol+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Plant+Extracts%22&quot;&gt;Plant Extracts*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Plant+Extracts+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Plant+Extracts%22&quot;&gt;Plant Extracts*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Plant+Extracts+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Intestinal+Mucosa%22&quot;&gt;Intestinal Mucosa&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Intestinal+Mucosa+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cytokines%22&quot;&gt;Cytokines&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cytokines+metabolism%22&quot;&gt;metabolism&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Animals%22&quot;&gt;Animals&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Mice%22&quot;&gt;Mice&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dextran+Sulfate%22&quot;&gt;Dextran Sulfate&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study systematically evaluated the intestinal mucosal protective effects of Dioscorea cirrhosa Lour. tuber&#39;s n-butanol fraction (rich in condensed tannins) against DSS-induced colitis using dual intragastric and enema administration. Analytical approaches included Disease Activity Index (DAI), haematoxylin and eosin (HE) staining, Alcian blue-periodic acid Schiff (AB-PAS) staining, ELISA, immunohistochemistry, immunofluorescence, and Western blot. LC-MS/MS identified the chemical constituents. Administering the DC n-butanol fractions through both routes significantly alleviated colitis symptoms (p &amp;lt; 0.05), including weight loss, and colon shortening. Histological analysis revealed reduced epithelial damage, decreased inflammatory cell infiltration, and increased goblet cell numbers with enhanced mucus production. Pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were markedly suppressed (p &amp;lt; 0.05). Furthermore, combined administration more effectively upregulated tight junction proteins (ZO-1, occludin, claudin-1) and MUC2 expression, thereby reinforcing intestinal mucosal barrier integrity. These findings highlight the therapeutic potential of D. cirrhosa fractions in ulcerative colitis management through dual anti-inflammatory and barrier-enhancing mechanisms.
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;Dioscorea cirrhosa Lour; LC-MS/MS; intestinal mucosal barrier; ulcerative colitis
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  Data: 0 (Anti-Inflammatory Agents)&lt;br /&gt;8PJ61P6TS3 (1-Butanol)&lt;br /&gt;0 (Plant Extracts)&lt;br /&gt;9042-14-2 (Dextran Sulfate)&lt;br /&gt;0 (Cytokines)
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20250807 &lt;i&gt;Date Completed: &lt;/i&gt;20260928 &lt;i&gt;Latest Revision: &lt;/i&gt;20260928
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  Data: 10.1080/14786419.2025.2544320
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  Data: 40771052
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        Value: 10.1080/14786419.2025.2544320
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        Text: English
    PhysicalDescription:
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        StartPage: 5711
    Subjects:
      – SubjectFull: Intestinal Mucosa drug effects
        Type: general
      – SubjectFull: Cytokines metabolism
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Male
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        Type: general
      – SubjectFull: Dioscorea chemistry
        Type: general
      – SubjectFull: Colitis, Ulcerative drug therapy
        Type: general
      – SubjectFull: Colitis, Ulcerative chemically induced
        Type: general
      – SubjectFull: Anti-Inflammatory Agents pharmacology
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      – SubjectFull: Anti-Inflammatory Agents chemistry
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      – SubjectFull: 1-Butanol chemistry
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        Type: general
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      – TitleFull: Enhanced therapeutic efficacy of Dioscorea cirrhosa Lour. n-butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects.
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              M: 09
              Text: 2026 Sep
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