Academic Journal
Enhanced therapeutic efficacy of Dioscorea cirrhosa Lour. n-butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects.
| Τίτλος: | Enhanced therapeutic efficacy of Dioscorea cirrhosa Lour. n-butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects. |
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| Συγγραφείς: | Wang M; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Peng X; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Yang C; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Yu X; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China., Tai H; College of Dai Medicine, West Yunnan University of Applied Sciences, Xishuangbanna, China., Li Y; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Sep; Vol. 40 (18), pp. 5711-5721. Date of Electronic Publication: 2025 Aug 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Dioscorea*/chemistry , Colitis, Ulcerative*/drug therapy , Colitis, Ulcerative*/chemically induced , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , 1-Butanol*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, Intestinal Mucosa/drug effects ; Cytokines/metabolism ; Animals ; Male ; Mice ; Dextran Sulfate |
| Περίληψη: | This study systematically evaluated the intestinal mucosal protective effects of Dioscorea cirrhosa Lour. tuber's n-butanol fraction (rich in condensed tannins) against DSS-induced colitis using dual intragastric and enema administration. Analytical approaches included Disease Activity Index (DAI), haematoxylin and eosin (HE) staining, Alcian blue-periodic acid Schiff (AB-PAS) staining, ELISA, immunohistochemistry, immunofluorescence, and Western blot. LC-MS/MS identified the chemical constituents. Administering the DC n-butanol fractions through both routes significantly alleviated colitis symptoms (p < 0.05), including weight loss, and colon shortening. Histological analysis revealed reduced epithelial damage, decreased inflammatory cell infiltration, and increased goblet cell numbers with enhanced mucus production. Pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were markedly suppressed (p < 0.05). Furthermore, combined administration more effectively upregulated tight junction proteins (ZO-1, occludin, claudin-1) and MUC2 expression, thereby reinforcing intestinal mucosal barrier integrity. These findings highlight the therapeutic potential of D. cirrhosa fractions in ulcerative colitis management through dual anti-inflammatory and barrier-enhancing mechanisms. |
| Contributed Indexing: | Keywords: Dioscorea cirrhosa Lour; LC-MS/MS; intestinal mucosal barrier; ulcerative colitis |
| Substance Nomenclature: | 0 (Anti-Inflammatory Agents) 8PJ61P6TS3 (1-Butanol) 0 (Plant Extracts) 9042-14-2 (Dextran Sulfate) 0 (Cytokines) |
| Entry Date(s): | Date Created: 20250807 Date Completed: 20260928 Latest Revision: 20260928 |
| Update Code: | 20260928 |
| DOI: | 10.1080/14786419.2025.2544320 |
| PMID: | 40771052 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2025.2544320 |