Academic Journal
NADH reductive stress drives metabolic reprogramming.
| Τίτλος: | NADH reductive stress drives metabolic reprogramming. |
|---|---|
| Συγγραφείς: | Yang R; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China., Guo Z; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China., Li B; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. Electronic address: bli@ccmu.edu.cn. |
| Πηγή: | Trends in cell biology [Trends Cell Biol] 2026 Mar; Vol. 36 (3), pp. 177-189. Date of Electronic Publication: 2025 Aug 05. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, UK : Elsevier Science Publishers, c1991- |
| Ιατρικοί όροι (MeSH): | NAD*/metabolism , Cellular Reprogramming*, Humans ; Animals ; Oxidation-Reduction ; Oxidative Stress ; Energy Metabolism ; Signal Transduction ; Metabolic Reprogramming |
| Περίληψη: | Cellular metabolism is intricately regulated by redox signaling, with the NADH/NAD+ couple serving as a central hub. Emerging evidence reveals that NADH reductive stress, marked by NADH accumulation, is not merely a passive byproduct of metabolic dysfunction but an active regulatory signal driving metabolic reprogramming. In this Review, we synthesize recent advances in understanding NADH reductive stress, including its origins, regulatory mechanism, and manipulation. We examine its broad impact on cellular metabolism, its interplay with oxidative and energy stress, and its pathogenic roles in a range of diseases. By integrating these findings, we propose NADH reductive stress as a master regulator for metabolic reprogramming and highlight new avenues for mechanistic exploration and therapeutic intervention. (Copyright © 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no conflicts of interest. |
| Contributed Indexing: | Keywords: NADH reductive stress; NADH-reductive-stress-associated diseases; energy stress; metabolic reprogramming; oxidative stress |
| Substance Nomenclature: | 0U46U6E8UK (NAD) |
| Entry Date(s): | Date Created: 20250806 Date Completed: 20260308 Latest Revision: 20260308 |
| Update Code: | 20260309 |
| DOI: | 10.1016/j.tcb.2025.07.005 |
| PMID: | 40769852 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-3088 |
|---|---|
| DOI: | 10.1016/j.tcb.2025.07.005 |