Academic Journal
Structural Analysis and Molecular Dynamics Simulations of Urease From Ureaplasma parvum.
| Τίτλος: | Structural Analysis and Molecular Dynamics Simulations of Urease From Ureaplasma parvum. |
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| Συγγραφείς: | Wu HN; Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Izumi City 594-1101 Osaka, Japan., Fujita J; Graduate School of Frontier Biosciences, The University of Osaka, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan; JEOL YOKOGUSHI Research Alliance Laboratories, The University of Osaka, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan., Nakura Y; Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Izumi City 594-1101 Osaka, Japan., Inoue M; Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Suzuki K; The Research Foundation for Microbial Diseases of Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan; BIKEN-RIMD NGS Laboratory, Research Institute for Microbial Diseases, The University of Osaka, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan., Ekimoto T; Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Yin B; Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Izumi City 594-1101 Osaka, Japan; Department of Pediatric and Neonatal-Perinatal Research, Affiliate Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita 565-0871 Osaka, Japan., Fukuda Y; Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, Japan., Harada K; Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan., Inoue T; Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, Japan., Ikeguchi M; Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan; RIKEN Center for Computational Science, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Namba K; Graduate School of Frontier Biosciences, The University of Osaka, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan; JEOL YOKOGUSHI Research Alliance Laboratories, The University of Osaka, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan., Yanagihara I; Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Izumi City 594-1101 Osaka, Japan; Department of Pediatric and Neonatal-Perinatal Research, Affiliate Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita 565-0871 Osaka, Japan. Electronic address: itaruy@wch.opho.jp. |
| Πηγή: | Journal of molecular biology [J Mol Biol] 2025 Nov 01; Vol. 437 (21), pp. 169368. Date of Electronic Publication: 2025 Aug 05. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: 1959- : London : Academic Press |
| Ιατρικοί όροι (MeSH): | Urease*/chemistry , Urease*/metabolism , Urease*/genetics , Ureaplasma*/enzymology, Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Molecular Dynamics Simulation ; Cryoelectron Microscopy ; Catalytic Domain ; Kinetics ; Protein Conformation |
| Περίληψη: | Ureaplasma is one of the smallest pathogenic bacteria, generating approximately 95% of its adenosine triphosphate (ATP) solely through urease. Studies on Ureaplasma parvum, a species of Ureaplasma, have confirmed that adding urease inhibitors inhibits bacterial growth. The K (Copyright © 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Ureaplasma; cryo-EM; mobile flap; molecular dynamics; urease |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Bacterial Proteins) |
| Entry Date(s): | Date Created: 20250802 Date Completed: 20251001 Latest Revision: 20251001 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jmb.2025.169368 |
| PMID: | 40752870 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1089-8638 |
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| DOI: | 10.1016/j.jmb.2025.169368 |