Academic Journal
Chemical composition and biological capacity of essential oils and ethanol extracts from endemic Nepeta species in the Armenian flora.
| Τίτλος: | Chemical composition and biological capacity of essential oils and ethanol extracts from endemic Nepeta species in the Armenian flora. |
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| Συγγραφείς: | Arshakyan N; Department of Pharmacognosy, Yerevan State Medical University, Yerevan, Republic of Armenia., Hovhannisyan V; Department of Pharmacognosy, Yerevan State Medical University, Yerevan, Republic of Armenia., Ghazaryan A; Department of Pharmacognosy, Yerevan State Medical University, Yerevan, Republic of Armenia., Grigoryan A; FDA Laboratory LLC, Nor Gyugh, Republic of Armenia.; Eurasia International University, Yerevan, Republic of Armenia., Danielyan K; Institute of Biochemistry after H. Buniatian, NAS RA, Yerevan, Republic of Armenia., Poghosyan G; Department of Medical Microbiology, Yerevan State Medical University, Yerevan, Republic of Armenia., Danielyan L; SPC 'Armbiotechnology', NAS RA, Yerevan, Republic of Armenia., Hovhannisyan H; SPC 'Armbiotechnology', NAS RA, Yerevan, Republic of Armenia., Feschyan S; Department of Medical Biology, Yerevan State Medical University, Yerevan, Republic of Armenia., Hovsepyan M; Department of Medical Biology, Yerevan State Medical University, Yerevan, Republic of Armenia., Sulashvili N; Department of Pharmacy, Tbilisi State Medical University, Tbilisi, Georgia., Kislichenko V; Department of Pharmacognosy and Nutriciology, National Pharmaceutical University, Kharkiv, Ukrainе., Chichoyan N; Department of Pharmacognosy, Yerevan State Medical University, Yerevan, Republic of Armenia. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Aug; Vol. 40 (15), pp. 4496-4509. Date of Electronic Publication: 2025 Jul 18. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Oils, Volatile*/chemistry , Oils, Volatile*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Antioxidants*/chemistry , Antioxidants*/pharmacology , Nepeta*/chemistry, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Ethanol/chemistry ; Enterococcus faecalis/drug effects ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Flavonoids/chemistry ; Flavonoids/analysis ; Sesquiterpenes/chemistry ; Microbial Sensitivity Tests ; Armenia ; Gas Chromatography-Mass Spectrometry |
| Περίληψη: | The chemical composition and biological activities of Nepeta species growing in Armenia were investigated. The essential oil composition was analysed using gas chromatography-mass spectrometry, which revealed the presence of key sesquiterpenes such as copaene (12.59%) and β-elemene (3.77%) across all samples. Antioxidant activity of the ethanolic extracts was evaluated via the DPPH radical scavenging assay, and total flavonoid content was determined, with N. sulphurea from Mantash showing the highest total flavonoid content (1.17 ± 0.23 mg RE/g DW). The essential oil and ethanolic extract of Nepeta sulphurea demonstrated the highest antibacterial and antifungal activity. The lowest MIC values (0.025-0.05 mg/mL) and the largest inhibition zones (30 mm) were recorded against Enterococcus faecalis. Notably, both the essential oils and ethanolic extracts from all Nepeta samples exhibited significant antimicrobial and antioxidant activities. This study contributes to the discovery and utilisation of herbs of Nepeta as a valuable source of biologically active compounds with therapeutic potential. Although Nepeta mussinii and Nepeta sulphurea growing in Armenia do not belong to any of the three established chemotype categories, further the results of their pharmacognostic and phytochemical screening can be used for the standardisation of different chemotypes of Nepeta. |
| Contributed Indexing: | Keywords: Nepeta mussinii (spreng); Nepeta sulphurea (C.Koch); antimicrobial activity; antiradical activity; copaene; essential oil; ethanol extract |
| Substance Nomenclature: | 0 (Oils, Volatile) 0 (Plant Extracts) 0 (Antioxidants) 0 (Anti-Bacterial Agents) 3K9958V90M (Ethanol) 0 (Antifungal Agents) 0 (Flavonoids) 0 (Sesquiterpenes) 0 (beta-elemene) |
| Entry Date(s): | Date Created: 20250718 Date Completed: 20260730 Latest Revision: 20260730 |
| Update Code: | 20260730 |
| DOI: | 10.1080/14786419.2025.2526756 |
| PMID: | 40677205 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2025.2526756 |