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Immunomodulatory and antioxidant responses of African catfish (Clarias gariepinus) to cestode infections: implications for intestinal health and aquaculture management.

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Τίτλος: Immunomodulatory and antioxidant responses of African catfish (Clarias gariepinus) to cestode infections: implications for intestinal health and aquaculture management.
Συγγραφείς: Radwan M; Marine Biology Branch, Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. MahmoudKhriy.201@azhar.edu.eg., Al Malki JS; Department of Biology, College of Science, Taif University, Taif, Saudi Arabia., Mohammadein A; Department of Biology, College of Science, Taif University, Taif, Saudi Arabia., Fares M; Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Πηγή: Veterinary research communications [Vet Res Commun] 2025 Jul 11; Vol. 49 (5), pp. 254. Date of Electronic Publication: 2025 Jul 11.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Switzerland NLM ID: 8100520 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7446 (Electronic) Linking ISSN: 01657380 NLM ISO Abbreviation: Vet Res Commun Subsets: MEDLINE
Imprint Name(s): Publication: [Cham] : Springer
Original Publication: [Amsterdam] : Elsevier, 1980-
Ιατρικοί όροι (MeSH): Catfishes*/parasitology , Catfishes*/immunology , Fish Diseases*/parasitology , Fish Diseases*/immunology , Cestode Infections*/veterinary , Cestode Infections*/immunology , Cestode Infections*/parasitology , Antioxidants*/metabolism, Cestoda/physiology ; Intestines/parasitology ; Intestines/pathology ; Animals ; Aquaculture
Περίληψη: Inadequate information exists on host-tapeworm parasite interactions in African catfish (Clarias gariepinus, Burchell 1822). Hence, this study evaluated the natural C. gariepinus severely infected mildly infected, on histopathological features, intestine health, immunological and antioxidant response to cestode parasites infection (Polyonchobothrium clarias (Woodland, 1925) Meggitt, 1930, Proteocephalus sp.). The prevalence of cestodes was 80%, with 26 and 52% of these fish mildly and severely infected, respectively. The prevalence was positively correlated with turbidity (0.64), NO2 (0.58), NO3 (0.63), and total alkalinity (0.57). Data illuminated that mildly and severely infected fish have more harmful effects on intestinal health and hemato-biochemical biomarkers than uninfected fish. Liver and intestinal antioxidant indices showed that the infected fish had higher malondialdehyde (MDA) levels than the uninfected fish. Correspondingly, mildly infected groups' liver and intestine showed significantly higher levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH), while severely infected groups showed lower levels. Data clarified that infected fish have significantly upregulated pro-inflammatory genes IL-1β, Tlr1, and C3 expression, especially in mildly infected, than uninfected fish. However, the expression of CAT and SOD genes was significantly downregulated, in the severely infected, along with higher expression of the HSP70 gene than those of the uninfected groups. The histopathological study revealed that fish infected with the cestode parasite had inflammatory and abnormal features, especially in severely infected fish groups. Hence, the study concluded that the cestode parasites induce pathological immunological responses and health status in C. gariepinus.
(© 2025. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Conflict of interest: The authors declare no competing interests.
References: Adv Clin Chem. 1983;23:199-257. (PMID: 6398614)
Fish Shellfish Immunol. 2017 Apr;63:334-343. (PMID: 28232278)
J Lab Clin Med. 1967 Jul;70(1):158-69. (PMID: 6066618)
Environ Pollut. 2024 Dec 1;362:124989. (PMID: 39306069)
Sci Rep. 2023 Sep 23;13(1):15900. (PMID: 37741912)
Am Nat. 2013 Aug;182(2):234-48. (PMID: 23852357)
Parasitol Res. 2021 Sep;120(9):3149-3162. (PMID: 34351490)
Sci Rep. 2023 Jun 19;13(1):9888. (PMID: 37337042)
Microb Pathog. 2023 Jan;174:105897. (PMID: 36528326)
Fish Shellfish Immunol. 2016 May;52:111-38. (PMID: 26944716)
Methods Enzymol. 1984;105:121-6. (PMID: 6727660)
Fish Shellfish Immunol. 2013 Jan;34(1):372-7. (PMID: 23159835)
J Biol Chem. 1969 Nov 25;244(22):6049-55. (PMID: 5389100)
Int J Parasitol Parasites Wildl. 2020 Dec 03;14:13-32. (PMID: 33384920)
BMC Vet Res. 2024 Jul 27;20(1):335. (PMID: 39068442)
Parasit Vectors. 2016 Apr 07;9:193. (PMID: 27056545)
J Adv Res. 2016 Mar;7(2):317-26. (PMID: 26966572)
Korean J Parasitol. 2009 Oct;47 Suppl:S125-31. (PMID: 19885328)
Biol Trace Elem Res. 2020 Jun;195(2):624-635. (PMID: 31396852)
Animals (Basel). 2023 Aug 14;13(16):. (PMID: 37627416)
J Helminthol. 2016 Nov;90(6):742-752. (PMID: 26743114)
Free Radic Biol Med. 2015 Nov;88(Pt B):93-100. (PMID: 26117331)
Anal Biochem. 1979 Jun;95(2):351-8. (PMID: 36810)
Clin Chem. 1963 Feb;9:102-8. (PMID: 14023392)
Int J Parasitol Parasites Wildl. 2024 Sep 14;25:100991. (PMID: 39329047)
Clin Chem. 1974 Apr;20(4):470-5. (PMID: 4818200)
Toxicol Rep. 2020 Aug 16;7:1075-1082. (PMID: 32923373)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Trends Parasitol. 2011 Mar;27(3):123-30. (PMID: 21144800)
Anat Histol Embryol. 2021 Jan;50(1):72-83. (PMID: 32794280)
Antioxidants (Basel). 2023 Dec 23;13(1):. (PMID: 38247462)
J Parasitol. 1997 Aug;83(4):575-83. (PMID: 9267395)
J Fish Dis. 2021 Dec;44(12):1883-1900. (PMID: 34529835)
Parasitology. 2022 Dec;149(14):1842-1861. (PMID: 36076315)
Sci Total Environ. 2024 Nov 15;951:175848. (PMID: 39209167)
Ecotoxicol Environ Saf. 2021 Aug;219:112322. (PMID: 33991931)
J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713)
Parasitol Int. 2017 Feb;66(1):871-883. (PMID: 27702602)
Am J Clin Pathol. 1957 Jul;28(1):56-63. (PMID: 13458125)
Exp Parasitol. 2018 May;188:1-7. (PMID: 29501694)
Ecotoxicology. 2022 Sep;31(7):1096-1110. (PMID: 35840811)
Contributed Indexing: Keywords: Polyonchobothrium clarias; Proteocephalus Sp.; Blood indices; Fish gut; Histopathological alterations; Immune-related gene
Substance Nomenclature: 0 (Antioxidants)
Entry Date(s): Date Created: 20250711 Date Completed: 20250711 Latest Revision: 20261010
Update Code: 20261010
DOI: 10.1007/s11259-025-10819-4
PMID: 40643779
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-7446
DOI:10.1007/s11259-025-10819-4