Academic Journal
Advanced ionic antibacterial solutions for dental caries prevention with enhanced aesthetic and demineralization functions.
| Τίτλος: | Advanced ionic antibacterial solutions for dental caries prevention with enhanced aesthetic and demineralization functions. |
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| Συγγραφείς: | Lin YC; School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore; BIOBOND LTD, Corsham, Wiltshire SN13 0BH, United Kingdom., Lin WR; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan., Chang K; Division of Oral Rehabilitation and Center of Pediatric Dentistry, Department of Dentistry, Taipei Medical University Hospital, Taipei 11031, Taiwan., Teng NC; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: dianaten@tmu.edu.tw., Yang JC; Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, New Taipei City 235603, Taiwan. Electronic address: yang820065@tmu.edu.tw., Chung RJ; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan; High-value Biomaterials Research and Commercialization Center, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan. Electronic address: rjchung@mail.ntut.edu.tw. |
| Πηγή: | Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2025 Oct; Vol. 41 (10), pp. 1189-1200. Date of Electronic Publication: 2025 Jul 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8508040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0097 (Electronic) Linking ISSN: 01095641 NLM ISO Abbreviation: Dent Mater Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1998- : Kidlington, Oxford, UK : Elsevier Science Original Publication: Copenhagen : Munksgaard, c1985- |
| Ιατρικοί όροι (MeSH): | Dental Caries*/prevention & control , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Quaternary Ammonium Compounds*/pharmacology , Quaternary Ammonium Compounds*/chemistry , Silver Compounds*/pharmacology , Silver Compounds*/chemistry , Cariostatic Agents*/pharmacology , Cariostatic Agents*/chemistry , Tooth Demineralization*/prevention & control, Metal Nanoparticles/chemistry ; Dentin/drug effects ; Silicon/chemistry ; Zinc/chemistry ; Silver/chemistry ; Humans ; Esthetics, Dental ; Animals ; Materials Testing ; Mice ; Cell Line ; Fluorides, Topical |
| Περίληψη: | Silver Diamine Fluoride (SDF) is a widely used agent for non-surgical dental caries treatment, offering effective antibacterial and remineralization benefits. However, its high silver ion concentration often results in black stains on treated surfaces, limiting patient acceptance due to aesthetic concerns. This study introduces a novel anti-caries solution incorporating zinc, titanium, and silicon ions, along with silver nanoparticles, to address these limitations. The formulation enables controlled ion release into dentinal tubules, providing sustained antibacterial effects while minimizing discoloration. It demonstrated superior biocompatibility with L929 and HGF-1 cells and reduced staining compared to SDF. Simulated oral environment tests confirmed its ability to form protective crystals, enhance dentin hardness, and inhibit collagen degradation, effectively suppressing caries progression. This solution offers an improved aesthetic and therapeutic option, particularly benefiting pediatric and special-needs patients. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Dental caries prevention; Ionic solution; Oral care; Silver Diamine Fluoride (SDF); Silver nanoparticles |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) DDU19UEV1Y (silver diamine fluoride) 0 (Quaternary Ammonium Compounds) 0 (Silver Compounds) Z4152N8IUI (Silicon) J41CSQ7QDS (Zinc) 0 (Cariostatic Agents) 3M4G523W1G (Silver) 0 (Fluorides, Topical) |
| Entry Date(s): | Date Created: 20250708 Date Completed: 20250910 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.dental.2025.07.002 |
| PMID: | 40628619 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0097 |
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| DOI: | 10.1016/j.dental.2025.07.002 |