Academic Journal
Acute exogenous lipoid pneumonia leading to severe ARDS: a case report.
| Τίτλος: | Acute exogenous lipoid pneumonia leading to severe ARDS: a case report. |
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| Συγγραφείς: | Ye Y; Department of Pulmonary and Critical Care Medicine, Huangshan People's Hospital, Huangshan, Anhui, China.; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Cai H; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Dai C; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China., Hu Q; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China., Cao Q; Department of Pulmonary and Critical Care Medicine, Nantong Haimen District People's Hospital, Nantong, Jiangsu, China., Bi J; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Song Y; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Jiang J; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Chen S; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. chen.shujing1@zs-hospital.sh.cn. |
| Πηγή: | BMC pulmonary medicine [BMC Pulm Med] 2025 Jul 02; Vol. 25 (1), pp. 306. Date of Electronic Publication: 2025 Jul 02. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001]- |
| Ιατρικοί όροι (MeSH): | Respiratory Distress Syndrome*/etiology , Respiratory Distress Syndrome*/therapy , Pneumonia, Lipid*/complications , Pneumonia, Lipid*/therapy , Pneumonia, Lipid*/diagnostic imaging , Mineral Oil*/adverse effects, Bronchoalveolar Lavage Fluid/chemistry ; Lung/diagnostic imaging ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed ; Respiration, Artificial ; Bronchoalveolar Lavage |
| Περίληψη: | Background: Exogenous lipoid pneumonia, a form of pneumonia caused by the aspiration of lipid substances, is often associated with the use of mineral oil. Historically, cases have predominantly been reported in young children, elderly, or individuals with compromised physical strength or neurological disorders, with the majority presenting as mild or chronic conditions. Upon cessation of exposure to lipids, symptoms typically showed improvement. Case Presentation: We report a case of a previously healthy middle-aged man who developed respiratory failure and severe acute respiratory distress syndrome (ARDS) following the accidental aspiration of sewing machine oil, and a chest computed tomography (CT) scan revealed consolidations in both lungs, with local attenuation visible in the mediastinal window. Lipid vacuoles were observed in the bronchoalveolar lavage fluid, and Oil Red O staining was positive, confirming the diagnosis. In terms of treatment, invasive mechanical ventilation was provided, along with intermittent prone positioning ventilation, segmented alveolar lavage, and systemic corticosteroids as part of a comprehensive treatment approach. The patient's oxygenation gradually improved, leading to stabilization, and follow-up chest CT three months later showed resolution of the lung lesions. Conclusion: The diagnosis of exogenous lipoid pneumonia is based on a history of lipid exposure, chest imaging, and the presence of lipid-laden macrophages in bronchoalveolar lavage fluid. However, there is currently no established treatment protocol. For critically ill patients, life support measures are crucial during the early stages or peak of the disease. Clinical Trial Number: Not applicable. (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent for participate: This work was approved by the Ethics Committee of Zhongshan Hospital, Fudan University, approval number [B2021-183(2)]. Consent for publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 2024ZD0530006 This research is supported by the National Major Science and Technology Project of China (Grant No. 2024ZD0530006). |
| Contributed Indexing: | Keywords: Acute respiratory distress syndrome; Bronchoalveolar lavage; Exogenous lipoid pneumonia; Mechanical ventilation; Prone position ventilation |
| Substance Nomenclature: | 8020-83-5 (Mineral Oil) |
| Entry Date(s): | Date Created: 20250703 Date Completed: 20250703 Latest Revision: 20250705 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12224776 |
| DOI: | 10.1186/s12890-025-03780-0 |
| PMID: | 40604803 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1471-2466 |
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| DOI: | 10.1186/s12890-025-03780-0 |