Academic Journal
Structural and functional neuroimaging of hippocampus to study adult neurogenesis in long COVID-19 patients with neuropsychiatric symptoms: a scoping review.
| Title: | Structural and functional neuroimaging of hippocampus to study adult neurogenesis in long COVID-19 patients with neuropsychiatric symptoms: a scoping review. |
|---|---|
| Authors: | Saikarthik J; Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Majmaah University, Al Majmaah, Saudi Arabia.; SIMATS University, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.; Department of Medical Education, University of Dundee, Dundee, United Kingdom., Saraswathi I; Department of Physiology, Madha Medical College and Research Institute, Chennai, India.; Department of Business Administration, Manipal Academy of Higher Education, Manipal, India., Padhi BK; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Shamim MA; Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India., Alzerwi N; Department of Surgery, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia., Alarifi A; Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia., Gandhi AP; Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India. |
| Source: | PeerJ [PeerJ] 2025 Jun 27; Vol. 13, pp. e19575. Date of Electronic Publication: 2025 Jun 27 (Print Publication: 2025). |
| Publication Type: | Journal Article; Scoping Review |
| Language: | English |
| Journal Info: | Publisher: PeerJ Inc Country of Publication: United States NLM ID: 101603425 Publication Model: eCollection Cited Medium: Internet ISSN: 2167-8359 (Electronic) Linking ISSN: 21678359 NLM ISO Abbreviation: PeerJ Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Corte Madera, CA : PeerJ Inc. |
| MeSH Terms: | COVID-19*/complications , COVID-19*/diagnostic imaging , COVID-19*/physiopathology , Hippocampus*/diagnostic imaging , Hippocampus*/physiopathology , Hippocampus*/pathology , Neurogenesis*/physiology , Mental Disorders*/diagnostic imaging , Mental Disorders*/physiopathology , Functional Neuroimaging*, Humans ; SARS-CoV-2 ; Adult ; Neuroimaging ; Magnetic Resonance Imaging |
| Abstract: | Background: Worsening of neuropsychiatric and neurodegenerative disorders occurs in COVID-19. Impaired adult neurogenesis is linked to most of the neuropsychiatric symptoms and disorders. Aim: The current scoping review identified and mapped the available evidence on adult neurogenesis in long COVID-19, at a global level following the JBI methodology for scoping reviews and followed the framework by Arksey and O'Malley. Method: Original studies focusing on structural and functional neuroimaging of the hippocampus to study adult neurogenesis in long COVID-19 were included in the review. Studies published in English language with no restriction on the time of publication were searched using the specified search strategy in PubMed, Web of Science, Embase, and SCOPUS. Articles obtained from the database search were collated and uploaded into the Nested Knowledge AutoLit semi-automated systematic review platform for data extraction. Results: The current review provides evidence of the potential alterations in adult neurogenesis in long COVID-19 and its potential link to neuropsychiatric sequelae of long COVID-19, with further research required to validate this assertion. Conclusion: This review proposes conceptual and methodological approaches for future investigations to address existing limitations and elucidate the precise role of adult neurogenesis in the pathophysiology and treatment of long COVID-19. (©2025 Saikarthik et al.) |
| Competing Interests: | Saikarthik Jayakumar is an academic Editor with PeerJ. Bijaya Kumar Padhi is an Academic Editor for PeerJ. |
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| Contributed Indexing: | Keywords: COVID-19; Hippocampus; Long COVID; Neurogenesis; Neuroimaging |
| Entry Date(s): | Date Created: 20250701 Date Completed: 20250701 Latest Revision: 20250707 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12208109 |
| DOI: | 10.7717/peerj.19575 |
| PMID: | 40589858 |
| Database: | MEDLINE |
| ISSN: | 2167-8359 |
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| DOI: | 10.7717/peerj.19575 |