Academic Journal
Kidney Stone Dissolution By Tetherless, Enzyme-Loaded, Soft Magnetic Miniature Robots.
| Τίτλος: | Kidney Stone Dissolution By Tetherless, Enzyme-Loaded, Soft Magnetic Miniature Robots. |
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| Συγγραφείς: | Khabbazian A; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Kwong L; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Lewis A; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Liu E; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Abdelrazec N; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Bakenecker AC; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Medical Engineering, Technical University of Darmstadt, Merckstr. 25, 64283, Darmstadt, Germany., Fontanals N; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Lopez G; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Sánchez S; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Catalan Institute for Research and Advanced Studies, ICREA, Barcelona, 08028, Spain., Lopez JM; Department of Urology, University of Barcelona Clinic Hospital, Barcelona, 08036, Spain., Carrillo B; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Farcas M; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Kallweit C; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada., Yu ACH; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada., Behrad Khamesee M; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Magdanz V; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada.; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada. |
| Πηγή: | Advanced healthcare materials [Adv Healthc Mater] 2025 Sep; Vol. 14 (23), pp. e2403423. Date of Electronic Publication: 2025 Jul 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Weinheim : Wiley-VCH, 2012- |
| Ιατρικοί όροι (MeSH): | Kidney Calculi*/therapy , Urease*/therapeutic use , Robotics*, Wireless Technology ; Magnetics ; Urinary Tract ; Humans ; Models, Anatomic ; Printing, Three-Dimensional ; Ultrasonography |
| Περίληψη: | Kidney stones are some of the most common urinary diseases, affecting 12% of the population. The high prevalence and recurrence of this disease urges the development of more targeted and effective treatment with lower side effects and less invasiveness avoiding recurrence and prolonged drug administration. Particularly for recurring stone formers, the current methods of persistent drug treatment and repetitive surgeries for stone removal are unsatisfying solutions that bring a huge burden to the patients and healthcare systems. For these reasons, a delivery strategy that provides drug administration at the disease site through active, wireless transport is urgently needed to improve urinary tract disease treatment. A wireless treatment of kidney stones is proposed with the help of flexible, magnetically steered, enzymatically active robots. These robots are designed to navigate in the urinary tract and locally dissolve the stones by action of embedded urease. The robots are made of millimeter-sized, gelatin-based polymer strips with embedded micromagnets and encapsulated urease which constantly converts urea to increase urinary pH. This study demonstrates enhanced stone dissolution and the robots' magnetic navigation through the different parts of a 3D printed human urinary tract model. A clinical ultrasound system allows real-time localization of the robots. This research proposes a less invasive and more targeted strategy for medical interventions in the urinary tract with potential to circumvent surgery in case of uric acid kidney stones, which is relevant especially in the light of high prevalence and recurrence of kidney stones. (© 2025 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.) |
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| Grant Information: | Graham Seed Fund; Discovery grant Natural Sciences and Engineering Research Council of Canada; LCF/BQ/PI21/11830003 'la Caixa' Foundation |
| Contributed Indexing: | Keywords: enzymatic; kidney stones; magnetic; microrobots; renal stones; soft robots |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) |
| Entry Date(s): | Date Created: 20250701 Date Completed: 20250926 Latest Revision: 20250926 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12417750 |
| DOI: | 10.1002/adhm.202403423 |
| PMID: | 40589273 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2192-2659 |
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| DOI: | 10.1002/adhm.202403423 |