Academic Journal
Two new compounds from euphorbia fischeriana steud. and their antitumor activity.
| Τίτλος: | Two new compounds from euphorbia fischeriana steud. and their antitumor activity. |
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| Συγγραφείς: | Sun Y; Qiqihar Medical University, Qiqihar, China., Ma T; Qiqihar Medical University, Qiqihar, China., Hong Y; Qiqihar Medical University, Qiqihar, China., Zhang J; Qiqihar Medical University, Qiqihar, China., Sun J; Qiqihar Medical University, Qiqihar, China., Liu Q; Qiqihar Medical University, Qiqihar, China., Guo L; Qiqihar Medical University, Qiqihar, China., Ma Y; Qiqihar Medical University, Qiqihar, China. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Aug; Vol. 40 (15), pp. 4435-4444. Date of Electronic Publication: 2025 Jun 27. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Euphorbia*/chemistry , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/isolation & purification, Apoptosis/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Plant Roots/chemistry ; bcl-2-Associated X Protein/metabolism ; Humans ; Molecular Structure ; Hep G2 Cells ; Drug Screening Assays, Antitumor ; HeLa Cells ; MCF-7 Cells ; Inhibitory Concentration 50 ; Animals ; Mice |
| Περίληψη: | Extraction from Euphorbia fischeriana Steud roots yielded twelve compounds, including two novel compounds 1 (15,16-dihydroxy-ent-abieta-8,11,13-triene) and 2 (methyl-12,14-dimethoxy-8-((5R,8R,9S,10R)-9-methoxy-4,4,10-trimethyldecahydronaphthalen-8yl)benzoate) along with ten previously documented compounds (3-12). Spectral analyses (1D-NMR, 2D-NMR and HR-ESI-MS) enabled the determination of their structural frameworks, supported by validation against published literature data. When tested in vitro, these compounds exhibited distinct potencies in suppressing the growth of Hela, HepG2, MCF-7 and C2C12 cells. Notably, compound 3 exerted significant inhibitory effects on all tested cell lines, showing IC |
| Contributed Indexing: | Keywords: Euphorbia fischeriana diterpenoids; antitumor activity; apoptosis; bcl-2/bax modulation |
| Substance Nomenclature: | 0 (Antineoplastic Agents, Phytogenic) 0 (Proto-Oncogene Proteins c-bcl-2) 0 (bcl-2-Associated X Protein) |
| Entry Date(s): | Date Created: 20250627 Date Completed: 20260730 Latest Revision: 20260730 |
| Update Code: | 20260730 |
| DOI: | 10.1080/14786419.2025.2521383 |
| PMID: | 40577107 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2025.2521383 |