Academic Journal
Implementation of a 90-Minute Gonorrhea/Chlamydia Test Decreases Antibiotic Under- and Overtreatment in Female Emergency Department Patients.
| Τίτλος: | Implementation of a 90-Minute Gonorrhea/Chlamydia Test Decreases Antibiotic Under- and Overtreatment in Female Emergency Department Patients. |
|---|---|
| Συγγραφείς: | Chinnock B; Department of Emergency Medicine, Fresno Medical Education Program, University of California, San Francisco, Fresno, California. Electronic address: brian.chinnock@ucsf.edu., Ramirez G; Department of Emergency Medicine, Fresno Medical Education Program, University of California, San Francisco, Fresno, California., Teran C; Department of Emergency Medicine, Fresno Medical Education Program, University of California, San Francisco, Fresno, California., Kouklis G; Department of Emergency Medicine, Fresno Medical Education Program, University of California, San Francisco, Fresno, California. |
| Πηγή: | The Journal of emergency medicine [J Emerg Med] 2025 Aug; Vol. 75, pp. 307-318. Date of Electronic Publication: 2025 Mar 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 8412174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0736-4679 (Print) Linking ISSN: 07364679 NLM ISO Abbreviation: J Emerg Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010>- : New York : Elsevier Original Publication: New York : Pergamon Press, c1983- |
| Ιατρικοί όροι (MeSH): | Gonorrhea*/diagnosis , Gonorrhea*/drug therapy , Anti-Bacterial Agents*/therapeutic use , Chlamydia Infections*/diagnosis , Chlamydia Infections*/drug therapy , Overtreatment*/statistics & numerical data, Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/statistics & numerical data ; Nucleic Acid Amplification Techniques/methods ; Neisseria gonorrhoeae/isolation & purification ; Chlamydia trachomatis/isolation & purification ; Humans ; Female ; Retrospective Studies ; Adult ; Time Factors ; Middle Aged |
| Περίληψη: | Background: Nucleic acid amplification testing (NAAT) of Chlamydia trachomatis and Neisseria gonorrhoeae (CT/NG) in emergency departments (EDs) with prolonged turnaround time (TAT) has resulted in high rates of under- and overtreatment in female patients. Objective: The aim of this study was to determine whether under- and overtreatment rates in an ED using a newer NAAT with a 90-min TAT would be decreased compared with an ED not using this test. Methods: We conducted a retrospective study examining female patients tested for CT/NG in the ED and compared under- and overtreatment rates during two different 70-week time periods before and after transition to the 90-min TAT in the intervention ED (ED-I) and no transition in the control ED (ED-C). We used an interrupted time series analysis of the data to determine the intervention effect. Results: There were 10,064 and 1990 CT/NG tests, respectively, in the ED-I and ED-C during the study period. Preintervention to postintervention, undertreatment went from 37% to 19% (18% decrease; 95% CI -17% to -20%) in ED-I, and from 42% to 40% (2% decrease; 95% CI -7% to 2%) in ED-C, respectively. Overtreatment rates changed from 27% to 17% (10% decrease; 95% CI -8% to -11%) in ED-I and from 37% to 33% (4% decrease; 95% CI -8% to 1%) in ED-C, respectively. Conclusions: Results of this real-world ED study showed that a 90-min TAT decreased under- and overtreatment rates for female patients tested for CT/NG. Future innovations that decrease TAT and process changes that decrease time to collection may improve these rates even further. (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest None. |
| Contributed Indexing: | Keywords: Cepheid; chlamydia; gonorrhea; nucleic acid amplification test; overtreatment; sexually transmitted infection; undertreatment |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20250622 Date Completed: 20250724 Latest Revision: 20260803 |
| Update Code: | 20260804 |
| DOI: | 10.1016/j.jemermed.2025.03.004 |
| PMID: | 40545401 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 0736-4679 |
|---|---|
| DOI: | 10.1016/j.jemermed.2025.03.004 |