Gram-Scale Synthesis of a Laccase-Like Cu36 Nanocluster with Enhanced Catalytic Activity and Stability.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Gram-Scale Synthesis of a Laccase-Like Cu36 Nanocluster with Enhanced Catalytic Activity and Stability.
Συγγραφείς:	Wang H; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China., Lin CL; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China., Fan E; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China., Yin HT; School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China., Zhang S; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China., Zhao Y; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China., Li MB; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China., Wu Z; Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China.; Institute of Solid State Physics Hefei Institutes of Physical Science, Hefei 230601, P. R. China.
Πηγή:	ACS nano [ACS Nano] 2025 Jul 15; Vol. 19 (27), pp. 25295-25303. Date of Electronic Publication: 2025 Jun 18.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
Imprint Name(s):	Original Publication: Washington D.C. : American Chemical Society
Ιατρικοί όροι (MeSH):	Laccase/chemistry , Laccase/metabolism , Copper/chemistry , Nanostructures/chemistry, Catalysis ; Oxidation-Reduction ; Enzyme Stability
Περίληψη:	The widespread development of natural laccase in applications is limited by its sensitivity to environmental conditions and high production costs. We report an atomically precise Cu36 nanoclusterzyme that is composed of a Cu22 core stabilized by seven Cu2L (L: 2-(2-(diphenylphosphaneyl)phenethyl)quinoline) staple units, three adamantanethiol (S-Adm) ligands, and one acetate ion (CH3COO^-). This Cu36 nanoclusterzyme demonstrates a laccase-like activity and exhibits dual functionality: (1) it catalyzes oxidation of phenolic pollutants with a maximum rate (4.12 μM·min^-1), which is 2.8 times greater than that of natural laccase and (2) it enables selective detection of epinephrine through a colorimetric response, with a detection limit of 0.43 μg/mL. Importantly, the Cu36 nanoclusterzyme is stable under extreme conditions, including extreme pH values, ionic strength, temperature, and storage time. It also preserves 80% catalytic efficiency after seven cycles and exhibits broad substrate specificity. These results demonstrate the application potential of the efficient Cu36 nanoclusterzyme in the fields of analytical chemistry, environmental protection, and biotechnology.
Contributed Indexing:	Keywords: Cu nanoclusters; epinephrine detection; laccase-like activity; nanoclusterzyme; phenolic compounds
Substance Nomenclature:	EC 1.10.3.2 (Laccase) 789U1901C5 (Copper)
Entry Date(s):	Date Created: 20250618 Date Completed: 20250715 Latest Revision: 20250715
Update Code:	20260130
DOI:	10.1021/acsnano.5c06249
PMID:	40533348
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1936-086X
DOI:	10.1021/acsnano.5c06249