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Strong concordance and correlation between direct alcohol biomarkers and alcohol self-report among youth with variable drinking patterns.

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Τίτλος: Strong concordance and correlation between direct alcohol biomarkers and alcohol self-report among youth with variable drinking patterns.
Συγγραφείς: Meredith LR; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address: meredith@musc.edu., Kirkland AE; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Green R; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Tomko RL; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Browning BD; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Gray KM; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Anton RF; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Miranda R Jr; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA., Squeglia LM; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Πηγή: Drug and alcohol dependence [Drug Alcohol Depend] 2025 Sep 01; Vol. 274, pp. 112734. Date of Electronic Publication: 2025 May 26.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Ireland NLM ID: 7513587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0046 (Electronic) Linking ISSN: 03768716 NLM ISO Abbreviation: Drug Alcohol Depend Subsets: MEDLINE
Imprint Name(s): Publication: Limerick : Elsevier
Original Publication: Lausanne, Elsevier Sequoia.
Ιατρικοί όροι (MeSH): Glycerophospholipids*/blood , Glucuronates*/urine , Alcohol Drinking*/urine , Alcohol Drinking*/blood , Alcohol Drinking*/psychology , Underage Drinking*/psychology , Self Report*, Biomarkers/blood ; Biomarkers/urine ; Humans ; Female ; Male ; Adolescent ; Young Adult
Περίληψη: Background: Heavy drinking among adolescents is associated with various consequences but is often undetected, limiting early intervention. Self-report of alcohol use has strengths but can be inaccurate due to recall biases and underreporting. Objective biomarkers may improve detection of drinking and related consequences, but few adolescent studies have assessed biomarker concordance with subjective self-report.
Methods: Youth aged 15-19 (54 % female) with minimal (n = 22) or heavy (n = 56) drinking patterns attended two research-related visits, approximately 13 days apart. Biospecimens were collected at both visits for urine ethylglucuronide (EtG) quantification (100ng/ml cutoff) and at visit two for whole blood phosphatidylethanol (PEth) quantification (20ng/ml cutoff). Cohen's Kappa concordance and Spearman's Rank Order correlations compared biomarkers and self-report drinking via Timeline Follow-back method. Exploratory analyses evaluated whether PEth improved model accuracy for alcohol-related severity outcomes beyond self-report.
Results: EtG had moderate concordance with any prior 2- or 3-day drinking (κ=.46-.53) at visit one but had substantial concordance by visit two (κ=.66-.80). PEth showed substantial concordance with any drinking (κ=.63-.66) and was strongly correlated with total drinks (rs=.80-.82) in prior 2- or 4-weeks. PEth and self-report drinking were not consistently associated with severity outcomes, although PEth improved model accuracy for select outcomes.
Conclusions: Findings largely support agreement of biomarkers with adolescent reported drinking in a research context without contingent rewards or punishments. Results suggest that collection of alcohol biomarkers may be most informative at an initial appointment to inform study eligibility. Quantity of alcohol consumption alone did not adequately account for youth-reported alcohol-related consequences.
(Copyright © 2025. Published by Elsevier B.V.)
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: KMG has provided consultation to Achieve Life Sciences, Indivior, and Jazz Pharmaceuticals, and has received research support from Aelis Farma.
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Grant Information: T32 DA007288 United States DA NIDA NIH HHS; K01 AA031745 United States AA NIAAA NIH HHS; K23 AA025399 United States AA NIAAA NIH HHS; K24 AA031052 United States AA NIAAA NIH HHS; P20 GM148302 United States GM NIGMS NIH HHS
Contributed Indexing: Keywords: Adolescent; Alcohol; Biomarker; Concordance; Ethylglucuronide; Phosphatidylethanol; Young adult
Substance Nomenclature: 0 (Biomarkers)
0 (Glycerophospholipids)
0 (phosphatidylethanol)
0 (Glucuronates)
17685-04-0 (ethyl glucuronide)
Entry Date(s): Date Created: 20250606 Date Completed: 20250729 Latest Revision: 20260807
Update Code: 20260807
PubMed Central ID: PMC12617837
DOI: 10.1016/j.drugalcdep.2025.112734
PMID: 40479923
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1879-0046
DOI:10.1016/j.drugalcdep.2025.112734