Academic Journal
Decreased Transient Receptor Potential Channel mRNA Expression in the Aortas of Patients with Hypertension.
| Τίτλος: | Decreased Transient Receptor Potential Channel mRNA Expression in the Aortas of Patients with Hypertension. |
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| Συγγραφείς: | Dokumacı AD; Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Türkiye., Alaşehirli B; Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Türkiye., Balcıoğlu AS; Department of Cardiology, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye., Balcı SO; Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Türkiye., Eser N; Department of Medical Pharmacology, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye., Çelik İS; Department of Medical Services and Techniques, Kahramanmaraş Health Services Vocational School, Pathology Laboratory Techniques Pr., Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye., Acıpayam M; Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye. |
| Πηγή: | Anatolian journal of cardiology [Anatol J Cardiol] 2026 Sep 01; Vol. 29 (9), pp. 472-479. Date of Electronic Publication: 2025 May 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: KARE publishing Country of Publication: Turkey NLM ID: 101652981 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2149-2271 (Electronic) Linking ISSN: 21492263 NLM ISO Abbreviation: Anatol J Cardiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : İstanbul, Turkey : KARE publishing Original Publication: İstanbul, Turkey : Aves, [2015]- |
| Ιατρικοί όροι (MeSH): | Hypertension*/genetics , Hypertension*/metabolism , RNA, Messenger*/metabolism , RNA, Messenger*/genetics , Transient Receptor Potential Channels*/genetics , Transient Receptor Potential Channels*/metabolism , Aorta*/metabolism, Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Aged ; Real-Time Polymerase Chain Reaction |
| Περίληψη: | Background: Arterial hypertension (HT) is a major risk factor for cardiovascular disease; however, its underlying mechanisms, particularly in primary HT, remain largely unclear. This knowledge gap has hindered the development of effective treatment strategies. Transient receptor potential (TRP) channels, which play a critical role in signal transduction, have been implicated in HT based on previous studies in cell culture and animal models. This study is the first study to analyze aortic tissue from patients with primary HT. Methods: Ascending aortic tissue samples, reflecting central blood pressure (BP), were collected from patients with chronic HT (n = 59) and normotensive controls (n = 22) undergoing coronary artery bypass graft surgery. Transient receptor potential channel mRNA expression was analyzed using quantitative real-time polymerase chain reaction. Subgroup analyses were performed to assess the influence of demographic characteristics, biochemical parameters, antihypertensive medications, and coexisting cardiometabolic conditions on gene expression. Results: Although no significant differences were observed in TRPC1 and TRPV3 mRNA expression between HT and control groups, TRPC6, TRPV1, TRPV2, TRPV4, and TRPM8 mRNA levels were significantly lower in patients with HT. TRPC6 expression showed a positive correlation with age, while TRPV1 expression demonstrated a negative correlation with diastolic BP. Conclusion: These findings suggest that TRP channels could serve as potential therapeutic targets for HT and contribute to a better understanding of its pathogenesis. |
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| Substance Nomenclature: | 0 (RNA, Messenger) 0 (Transient Receptor Potential Channels) |
| Entry Date(s): | Date Created: 20250602 Date Completed: 20260407 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13382930 |
| DOI: | 10.14744/AnatolJCardiol.2025.5123 |
| PMID: | 40454880 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2149-2271 |
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| DOI: | 10.14744/AnatolJCardiol.2025.5123 |