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The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study.
Συγγραφείς: Atsumi T; Department of Medical Physiology, Kyorin University, Tokyo, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp.; Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp., Ide M; Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan., Chakrabarty M; Department of Social Sciences and Humanities, Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India.; Centre for Design and New Media, Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India., Terao Y; Department of Medical Physiology, Kyorin University, Tokyo, Japan.
Πηγή: Scientific reports [Sci Rep] 2025 May 21; Vol. 15 (1), pp. 17674. Date of Electronic Publication: 2025 May 21.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s): Original Publication: London : Nature Publishing Group, copyright 2011-
Ιατρικοί όροι (MeSH): Autism Spectrum Disorder*/physiopathology , Autism Spectrum Disorder*/psychology , Autism Spectrum Disorder*/diagnostic imaging , Anxiety*/physiopathology , Time Perception*/physiology, Emotions/physiology ; Amygdala/physiopathology ; Brain/physiopathology ; Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Female ; Young Adult ; Adult ; Facial Expression ; Adolescent ; Brain Mapping
Περίληψη: The atypical sensory features and high comorbidity of anxiety disorders in individuals with autism spectrum disorder (ASD) are attracting increasing attention. Among individuals with ASD, those who exhibit heightened sensory hyperresponsiveness tend to show enhanced temporal processing of sensory stimuli, despite no observed differences in stimulus detection thresholds. A previous study reported the role of anxiety in modulating emotion-cued changes of visual temporal resolution in ASD. Building on this, we hypothesized that elevated anxiety might contribute to increased activation of neural circuits for timing perception and sensory hyperresponsiveness. This study included 25 individuals with ASD and 25 typically developed (TD) participants. Using functional magnetic resonance imaging (fMRI), we examined neural activity during a visual temporal order judgment task pre-cued by facial emotions. In the TD group, but not the ASD group, the presence of fearful facial expressions enhanced temporal processing. However, a correlation of anxiety levels with emotion-cued task performance and sensory hyperresponsiveness, respectively, was evident in the ASD group. In the TD group, neuroimaging revealed greater activation of the right caudate compared with that in the ASD group and a functional connectivity between the amygdala and left supramarginal gyrus. Individuals with ASD showed a relationship between anxiety level and activation of the right angular gyrus. Moreover, anxiety mediated the link between right angular gyrus activation and sensory hyperresponsiveness in the ASD group. These findings suggest that enhancement of temporal processing by fear-related cues-reflecting an emotion-timing neural circuit-may be disrupted in individuals with ASD. Heightened anxiety and sensory hyperresponsiveness in ASD may be mediated by brain regions involved in timing perception.
(© 2025. The Author(s).)
Competing Interests: Competing interests: The authors declare no competing interests. Ethics approval: This study was reviewed and approved by the ethics committee of Kyorin University and the National Rehabilitation Center for Persons with Disabilities. This study was carried out in accordance with the Declaration of Helsinki and the guidelines for human research of both institutes. Written informed consent to participate in this study was provided by the participants themselves. Written informed consent was obtained from the individual(s) for publication of any potentially identifiable images or data included in this manuscript.
References: Arch Gen Psychiatry. 2010 Apr;67(4):397-405. (PMID: 20368515)
Neuropsychologia. 2021 Jan 8;150:107694. (PMID: 33249169)
Neuroimage. 2002 Jan;15(1):273-89. (PMID: 11771995)
Brain. 2012 Mar;135(Pt 3):656-77. (PMID: 21921020)
Am J Psychiatry. 2019 Dec 1;176(12):1010-1020. (PMID: 31230465)
Hum Brain Mapp. 2014 Apr;35(4):1284-96. (PMID: 23334984)
Nat Rev Neurosci. 2005 Oct;6(10):755-65. (PMID: 16163383)
J Neurosci. 2007 Apr 11;27(15):3994-7. (PMID: 17428974)
J Child Psychol Psychiatry. 2020 Dec;61(12):1317-1327. (PMID: 32115711)
Cortex. 2023 Jul;164:144-151. (PMID: 37209610)
Neuroimage. 2003 Nov;20 Suppl 1:S82-8. (PMID: 14597300)
Front Neurosci. 2020 May 19;14:482. (PMID: 32508576)
Sci Rep. 2016 Apr 11;6:23323. (PMID: 27064734)
Am J Occup Ther. 2001 Jan-Feb;55(1):75-82. (PMID: 11216370)
Cell Rep. 2013 Nov 14;5(3):567-72. (PMID: 24210815)
J Child Psychol Psychiatry. 2021 Oct;62(10):1183-1194. (PMID: 33587311)
Biophys J. 1993 Mar;64(3):803-12. (PMID: 8386018)
Autism Res. 2020 Dec;13(12):2038-2057. (PMID: 32978905)
Behav Res Methods. 2019 Feb;51(1):195-203. (PMID: 30734206)
Acta Biomed. 2020 Jun 25;91(3):e2020070. (PMID: 32921765)
Hum Brain Mapp. 2013 Dec;34(12):3247-66. (PMID: 22806915)
PLoS One. 2016 Jan 19;11(1):e0147112. (PMID: 26784347)
Neurosci Biobehav Rev. 2020 Sep;116:44-63. (PMID: 32544540)
Neuroimage. 2010 Jan 15;49(2):1728-40. (PMID: 19800975)
Autism. 2019 May;23(4):1028-1041. (PMID: 30244585)
J Cogn Neurosci. 2008 Dec;20(12):2167-74. (PMID: 18457504)
Am J Occup Ther. 2001 Nov-Dec;55(6):608-20. (PMID: 12959225)
Soc Cogn Affect Neurosci. 2012 Jun;7(5):604-9. (PMID: 22569188)
Am J Occup Ther. 2007 Mar-Apr;61(2):190-200. (PMID: 17436841)
Nihon Eiseigaku Zasshi. 1989 Feb;43(6):1116-23. (PMID: 2746980)
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:412-426. (PMID: 30381235)
Perception. 2024 Sep;53(9):585-596. (PMID: 38863412)
J Am Dent Assoc. 2023 Mar;154(3):206-214. (PMID: 36707274)
Soc Cogn Affect Neurosci. 2018 Jan 1;13(1):102-113. (PMID: 29140527)
J Pers Soc Psychol. 1986 Dec;51(6):1173-82. (PMID: 3806354)
Commun Biol. 2018 Dec 21;1:233. (PMID: 30588512)
Cereb Cortex. 2013 Aug;23(8):1952-64. (PMID: 22761307)
Neuroimage. 2004 Jan;21(1):450-5. (PMID: 14741682)
J Neurophysiol. 2019 Oct 1;122(4):1530-1537. (PMID: 31166811)
Neuroimage. 2022 Aug 15;257:119296. (PMID: 35561944)
PLoS Biol. 2015 Sep 17;13(9):e1002262. (PMID: 26378440)
Neuroimage. 2003 Jul;19(3):1233-9. (PMID: 12880848)
Psychiatry Res. 2009 Aug 15;168(3):242-9. (PMID: 19564050)
PLoS One. 2018 Feb 15;13(2):e0193100. (PMID: 29447256)
J Autism Dev Disord. 2020 Jan;50(1):308-318. (PMID: 31621020)
Emotion. 2011 Aug;11(4):907-20. (PMID: 21859206)
Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718):. (PMID: 28242739)
Neuroimage. 2011 Jun 15;56(4):2348-55. (PMID: 21497657)
Biol Psychol. 2011 Mar;86(3):247-53. (PMID: 21184798)
Front Neurosci. 2020 Apr 30;14:340. (PMID: 32425746)
Prog Orthod. 2019 Aug 1;20(1):29. (PMID: 31367995)
J Neurosci. 2009 Nov 25;29(47):14803-11. (PMID: 19940175)
Eur J Neurosci. 2021 Jul;54(2):4682-4694. (PMID: 33998735)
J Neurosci. 2020 Sep 30;40(40):7749-7758. (PMID: 32928883)
Brain Connect. 2013;3(5):536-45. (PMID: 23988147)
PLoS One. 2015 Jun 01;10(6):e0128932. (PMID: 26030871)
J Neurodev Disord. 2021 Jan 6;13(1):5. (PMID: 33407072)
Front Pediatr. 2014 Jul 08;2:70. (PMID: 25072038)
Psychiatry Res. 2023 Jan;319:114971. (PMID: 36459805)
Transl Psychiatry. 2021 Jan 12;11(1):39. (PMID: 33436538)
Clin Psychol Rev. 2009 Feb;29(1):34-46. (PMID: 18977061)
Shinrigaku Kenkyu. 2004 Apr;75(1):78-84. (PMID: 15724518)
J Autism Dev Disord. 2019 Jan;49(1):44-53. (PMID: 30019275)
Sci Rep. 2016 Jan 13;6:19381. (PMID: 26758779)
Curr Opin Neurobiol. 2008 Apr;18(2):166-72. (PMID: 18655833)
Autism Res. 2020 May;13(5):785-795. (PMID: 31909874)
Brain. 2007 Jul;130(Pt 7):1718-31. (PMID: 17392317)
J Autism Dev Disord. 2001 Feb;31(1):5-17. (PMID: 11439754)
J Autism Dev Disord. 2023 May;53(5):1884-1905. (PMID: 35119604)
Neuroimage. 2005 May 1;25(4):1325-35. (PMID: 15850749)
Neuroimage. 2008 Aug 15;42(2):717-25. (PMID: 18572418)
Neurosci Biobehav Rev. 2017 Dec;83:1-10. (PMID: 28963037)
Front Psychol. 2022 May 06;13:881799. (PMID: 35645897)
J Neurosci. 2009 Mar 11;29(10):3182-8. (PMID: 19279255)
Genes Brain Behav. 2003 Oct;2(5):255-67. (PMID: 14606691)
Grant Information: JP24H01558 Ministry of Education, Culture, Sports, Science and Technology; JP18H05523 Ministry of Education, Culture, Sports, Science and Technology; JP20K14262 Japan Society for the Promotion of Science; 2021 Meiji Yasuda Mental Health Foundation
Contributed Indexing: Keywords: Anxiety; Autism spectrum disorder; Sensory over-responsivity; Sensory processing; fMRI
Entry Date(s): Date Created: 20250521 Date Completed: 20250521 Latest Revision: 20250524
Update Code: 20260130
PubMed Central ID: PMC12095537
DOI: 10.1038/s41598-025-02117-5
PMID: 40399452
Βάση Δεδομένων: MEDLINE
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  Data: The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study.
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  Data: <searchLink fieldCode="AU" term="%22Atsumi+T%22">Atsumi T</searchLink>; Department of Medical Physiology, Kyorin University, Tokyo, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp.; Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ide+M%22">Ide M</searchLink>; Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+M%22">Chakrabarty M</searchLink>; Department of Social Sciences and Humanities, Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India.; Centre for Design and New Media, Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India.<br /><searchLink fieldCode="AU" term="%22Terao+Y%22">Terao Y</searchLink>; Department of Medical Physiology, Kyorin University, Tokyo, Japan.
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  Data: <searchLink fieldCode="MM" term="%22Autism+Spectrum+Disorder%22">Autism Spectrum Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Autism+Spectrum+Disorder+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Autism+Spectrum+Disorder%22">Autism Spectrum Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Autism+Spectrum+Disorder+psychology%22">psychology</searchLink> <br /><searchLink fieldCode="MM" term="%22Autism+Spectrum+Disorder%22">Autism Spectrum Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Autism+Spectrum+Disorder+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Anxiety%22">Anxiety*</searchLink>/<searchLink fieldCode="MM" term="%22Anxiety+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Time+Perception%22">Time Perception*</searchLink>/<searchLink fieldCode="MM" term="%22Time+Perception+physiology%22">physiology</searchLink><br /><searchLink fieldCode="MH" term="%22Emotions%22">Emotions</searchLink>/<searchLink fieldCode="MH" term="%22Emotions+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Amygdala%22">Amygdala</searchLink>/<searchLink fieldCode="MH" term="%22Amygdala+physiopathology%22">physiopathology</searchLink> ; <searchLink fieldCode="MH" term="%22Brain%22">Brain</searchLink>/<searchLink fieldCode="MH" term="%22Brain+physiopathology%22">physiopathology</searchLink> ; <searchLink fieldCode="MH" term="%22Brain%22">Brain</searchLink>/<searchLink fieldCode="MH" term="%22Brain+diagnostic+imaging%22">diagnostic imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Magnetic+Resonance+Imaging%22">Magnetic Resonance Imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Young+Adult%22">Young Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Facial+Expression%22">Facial Expression</searchLink> ; <searchLink fieldCode="MH" term="%22Adolescent%22">Adolescent</searchLink> ; <searchLink fieldCode="MH" term="%22Brain+Mapping%22">Brain Mapping</searchLink>
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  Data: The atypical sensory features and high comorbidity of anxiety disorders in individuals with autism spectrum disorder (ASD) are attracting increasing attention. Among individuals with ASD, those who exhibit heightened sensory hyperresponsiveness tend to show enhanced temporal processing of sensory stimuli, despite no observed differences in stimulus detection thresholds. A previous study reported the role of anxiety in modulating emotion-cued changes of visual temporal resolution in ASD. Building on this, we hypothesized that elevated anxiety might contribute to increased activation of neural circuits for timing perception and sensory hyperresponsiveness. This study included 25 individuals with ASD and 25 typically developed (TD) participants. Using functional magnetic resonance imaging (fMRI), we examined neural activity during a visual temporal order judgment task pre-cued by facial emotions. In the TD group, but not the ASD group, the presence of fearful facial expressions enhanced temporal processing. However, a correlation of anxiety levels with emotion-cued task performance and sensory hyperresponsiveness, respectively, was evident in the ASD group. In the TD group, neuroimaging revealed greater activation of the right caudate compared with that in the ASD group and a functional connectivity between the amygdala and left supramarginal gyrus. Individuals with ASD showed a relationship between anxiety level and activation of the right angular gyrus. Moreover, anxiety mediated the link between right angular gyrus activation and sensory hyperresponsiveness in the ASD group. These findings suggest that enhancement of temporal processing by fear-related cues-reflecting an emotion-timing neural circuit-may be disrupted in individuals with ASD. Heightened anxiety and sensory hyperresponsiveness in ASD may be mediated by brain regions involved in timing perception.<br /> (© 2025. The Author(s).)
– Name: Abstract
  Label: Competing Interests
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  Data: Competing interests: The authors declare no competing interests. Ethics approval: This study was reviewed and approved by the ethics committee of Kyorin University and the National Rehabilitation Center for Persons with Disabilities. This study was carried out in accordance with the Declaration of Helsinki and the guidelines for human research of both institutes. Written informed consent to participate in this study was provided by the participants themselves. Written informed consent was obtained from the individual(s) for publication of any potentially identifiable images or data included in this manuscript.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Arch Gen Psychiatry. 2010 Apr;67(4):397-405. (PMID: <searchLink fieldCode="PM" term="%2220368515%22">20368515)</searchLink><br />Neuropsychologia. 2021 Jan 8;150:107694. (PMID: <searchLink fieldCode="PM" term="%2233249169%22">33249169)</searchLink><br />Neuroimage. 2002 Jan;15(1):273-89. (PMID: <searchLink fieldCode="PM" term="%2211771995%22">11771995)</searchLink><br />Brain. 2012 Mar;135(Pt 3):656-77. (PMID: <searchLink fieldCode="PM" term="%2221921020%22">21921020)</searchLink><br />Am J Psychiatry. 2019 Dec 1;176(12):1010-1020. (PMID: <searchLink fieldCode="PM" term="%2231230465%22">31230465)</searchLink><br />Hum Brain Mapp. 2014 Apr;35(4):1284-96. (PMID: <searchLink fieldCode="PM" term="%2223334984%22">23334984)</searchLink><br />Nat Rev Neurosci. 2005 Oct;6(10):755-65. (PMID: <searchLink fieldCode="PM" term="%2216163383%22">16163383)</searchLink><br />J Neurosci. 2007 Apr 11;27(15):3994-7. (PMID: <searchLink fieldCode="PM" term="%2217428974%22">17428974)</searchLink><br />J Child Psychol Psychiatry. 2020 Dec;61(12):1317-1327. (PMID: <searchLink fieldCode="PM" term="%2232115711%22">32115711)</searchLink><br />Cortex. 2023 Jul;164:144-151. (PMID: <searchLink fieldCode="PM" term="%2237209610%22">37209610)</searchLink><br />Neuroimage. 2003 Nov;20 Suppl 1:S82-8. (PMID: <searchLink fieldCode="PM" term="%2214597300%22">14597300)</searchLink><br />Front Neurosci. 2020 May 19;14:482. (PMID: <searchLink fieldCode="PM" term="%2232508576%22">32508576)</searchLink><br />Sci Rep. 2016 Apr 11;6:23323. (PMID: <searchLink fieldCode="PM" term="%2227064734%22">27064734)</searchLink><br />Am J Occup Ther. 2001 Jan-Feb;55(1):75-82. (PMID: <searchLink fieldCode="PM" term="%2211216370%22">11216370)</searchLink><br />Cell Rep. 2013 Nov 14;5(3):567-72. (PMID: <searchLink fieldCode="PM" term="%2224210815%22">24210815)</searchLink><br />J Child Psychol Psychiatry. 2021 Oct;62(10):1183-1194. (PMID: <searchLink fieldCode="PM" term="%2233587311%22">33587311)</searchLink><br />Biophys J. 1993 Mar;64(3):803-12. (PMID: <searchLink fieldCode="PM" term="%228386018%22">8386018)</searchLink><br />Autism Res. 2020 Dec;13(12):2038-2057. (PMID: <searchLink fieldCode="PM" term="%2232978905%22">32978905)</searchLink><br />Behav Res Methods. 2019 Feb;51(1):195-203. (PMID: <searchLink fieldCode="PM" term="%2230734206%22">30734206)</searchLink><br />Acta Biomed. 2020 Jun 25;91(3):e2020070. (PMID: <searchLink fieldCode="PM" term="%2232921765%22">32921765)</searchLink><br />Hum Brain Mapp. 2013 Dec;34(12):3247-66. (PMID: <searchLink fieldCode="PM" term="%2222806915%22">22806915)</searchLink><br />PLoS One. 2016 Jan 19;11(1):e0147112. (PMID: <searchLink fieldCode="PM" term="%2226784347%22">26784347)</searchLink><br />Neurosci Biobehav Rev. 2020 Sep;116:44-63. (PMID: <searchLink fieldCode="PM" term="%2232544540%22">32544540)</searchLink><br />Neuroimage. 2010 Jan 15;49(2):1728-40. (PMID: <searchLink fieldCode="PM" term="%2219800975%22">19800975)</searchLink><br />Autism. 2019 May;23(4):1028-1041. (PMID: <searchLink fieldCode="PM" term="%2230244585%22">30244585)</searchLink><br />J Cogn Neurosci. 2008 Dec;20(12):2167-74. (PMID: <searchLink fieldCode="PM" term="%2218457504%22">18457504)</searchLink><br />Am J Occup Ther. 2001 Nov-Dec;55(6):608-20. (PMID: <searchLink fieldCode="PM" term="%2212959225%22">12959225)</searchLink><br />Soc Cogn Affect Neurosci. 2012 Jun;7(5):604-9. (PMID: <searchLink fieldCode="PM" term="%2222569188%22">22569188)</searchLink><br />Am J Occup Ther. 2007 Mar-Apr;61(2):190-200. (PMID: <searchLink fieldCode="PM" term="%2217436841%22">17436841)</searchLink><br />Nihon Eiseigaku Zasshi. 1989 Feb;43(6):1116-23. (PMID: <searchLink fieldCode="PM" term="%222746980%22">2746980)</searchLink><br />Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:412-426. (PMID: <searchLink fieldCode="PM" term="%2230381235%22">30381235)</searchLink><br />Perception. 2024 Sep;53(9):585-596. (PMID: <searchLink fieldCode="PM" term="%2238863412%22">38863412)</searchLink><br />J Am Dent Assoc. 2023 Mar;154(3):206-214. (PMID: <searchLink fieldCode="PM" term="%2236707274%22">36707274)</searchLink><br />Soc Cogn Affect Neurosci. 2018 Jan 1;13(1):102-113. (PMID: <searchLink fieldCode="PM" term="%2229140527%22">29140527)</searchLink><br />J Pers Soc Psychol. 1986 Dec;51(6):1173-82. (PMID: <searchLink fieldCode="PM" term="%223806354%22">3806354)</searchLink><br />Commun Biol. 2018 Dec 21;1:233. (PMID: <searchLink fieldCode="PM" term="%2230588512%22">30588512)</searchLink><br />Cereb Cortex. 2013 Aug;23(8):1952-64. (PMID: <searchLink fieldCode="PM" term="%2222761307%22">22761307)</searchLink><br />Neuroimage. 2004 Jan;21(1):450-5. (PMID: <searchLink fieldCode="PM" term="%2214741682%22">14741682)</searchLink><br />J Neurophysiol. 2019 Oct 1;122(4):1530-1537. (PMID: <searchLink fieldCode="PM" term="%2231166811%22">31166811)</searchLink><br />Neuroimage. 2022 Aug 15;257:119296. (PMID: <searchLink fieldCode="PM" term="%2235561944%22">35561944)</searchLink><br />PLoS Biol. 2015 Sep 17;13(9):e1002262. (PMID: <searchLink fieldCode="PM" term="%2226378440%22">26378440)</searchLink><br />Neuroimage. 2003 Jul;19(3):1233-9. (PMID: <searchLink fieldCode="PM" term="%2212880848%22">12880848)</searchLink><br />Psychiatry Res. 2009 Aug 15;168(3):242-9. (PMID: <searchLink fieldCode="PM" term="%2219564050%22">19564050)</searchLink><br />PLoS One. 2018 Feb 15;13(2):e0193100. (PMID: <searchLink fieldCode="PM" term="%2229447256%22">29447256)</searchLink><br />J Autism Dev Disord. 2020 Jan;50(1):308-318. (PMID: <searchLink fieldCode="PM" term="%2231621020%22">31621020)</searchLink><br />Emotion. 2011 Aug;11(4):907-20. (PMID: <searchLink fieldCode="PM" term="%2221859206%22">21859206)</searchLink><br />Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718):. (PMID: <searchLink fieldCode="PM" term="%2228242739%22">28242739)</searchLink><br />Neuroimage. 2011 Jun 15;56(4):2348-55. (PMID: <searchLink fieldCode="PM" term="%2221497657%22">21497657)</searchLink><br />Biol Psychol. 2011 Mar;86(3):247-53. (PMID: <searchLink fieldCode="PM" term="%2221184798%22">21184798)</searchLink><br />Front Neurosci. 2020 Apr 30;14:340. (PMID: <searchLink fieldCode="PM" term="%2232425746%22">32425746)</searchLink><br />Prog Orthod. 2019 Aug 1;20(1):29. (PMID: <searchLink fieldCode="PM" term="%2231367995%22">31367995)</searchLink><br />J Neurosci. 2009 Nov 25;29(47):14803-11. (PMID: <searchLink fieldCode="PM" term="%2219940175%22">19940175)</searchLink><br />Eur J Neurosci. 2021 Jul;54(2):4682-4694. (PMID: <searchLink fieldCode="PM" term="%2233998735%22">33998735)</searchLink><br />J Neurosci. 2020 Sep 30;40(40):7749-7758. (PMID: <searchLink fieldCode="PM" term="%2232928883%22">32928883)</searchLink><br />Brain Connect. 2013;3(5):536-45. (PMID: <searchLink fieldCode="PM" term="%2223988147%22">23988147)</searchLink><br />PLoS One. 2015 Jun 01;10(6):e0128932. (PMID: <searchLink fieldCode="PM" term="%2226030871%22">26030871)</searchLink><br />J Neurodev Disord. 2021 Jan 6;13(1):5. (PMID: <searchLink fieldCode="PM" term="%2233407072%22">33407072)</searchLink><br />Front Pediatr. 2014 Jul 08;2:70. (PMID: <searchLink fieldCode="PM" term="%2225072038%22">25072038)</searchLink><br />Psychiatry Res. 2023 Jan;319:114971. (PMID: <searchLink fieldCode="PM" term="%2236459805%22">36459805)</searchLink><br />Transl Psychiatry. 2021 Jan 12;11(1):39. (PMID: <searchLink fieldCode="PM" term="%2233436538%22">33436538)</searchLink><br />Clin Psychol Rev. 2009 Feb;29(1):34-46. (PMID: <searchLink fieldCode="PM" term="%2218977061%22">18977061)</searchLink><br />Shinrigaku Kenkyu. 2004 Apr;75(1):78-84. (PMID: <searchLink fieldCode="PM" term="%2215724518%22">15724518)</searchLink><br />J Autism Dev Disord. 2019 Jan;49(1):44-53. (PMID: <searchLink fieldCode="PM" term="%2230019275%22">30019275)</searchLink><br />Sci Rep. 2016 Jan 13;6:19381. (PMID: <searchLink fieldCode="PM" term="%2226758779%22">26758779)</searchLink><br />Curr Opin Neurobiol. 2008 Apr;18(2):166-72. (PMID: <searchLink fieldCode="PM" term="%2218655833%22">18655833)</searchLink><br />Autism Res. 2020 May;13(5):785-795. (PMID: <searchLink fieldCode="PM" term="%2231909874%22">31909874)</searchLink><br />Brain. 2007 Jul;130(Pt 7):1718-31. (PMID: <searchLink fieldCode="PM" term="%2217392317%22">17392317)</searchLink><br />J Autism Dev Disord. 2001 Feb;31(1):5-17. (PMID: <searchLink fieldCode="PM" term="%2211439754%22">11439754)</searchLink><br />J Autism Dev Disord. 2023 May;53(5):1884-1905. (PMID: <searchLink fieldCode="PM" term="%2235119604%22">35119604)</searchLink><br />Neuroimage. 2005 May 1;25(4):1325-35. (PMID: <searchLink fieldCode="PM" term="%2215850749%22">15850749)</searchLink><br />Neuroimage. 2008 Aug 15;42(2):717-25. (PMID: <searchLink fieldCode="PM" term="%2218572418%22">18572418)</searchLink><br />Neurosci Biobehav Rev. 2017 Dec;83:1-10. (PMID: <searchLink fieldCode="PM" term="%2228963037%22">28963037)</searchLink><br />Front Psychol. 2022 May 06;13:881799. (PMID: <searchLink fieldCode="PM" term="%2235645897%22">35645897)</searchLink><br />J Neurosci. 2009 Mar 11;29(10):3182-8. (PMID: <searchLink fieldCode="PM" term="%2219279255%22">19279255)</searchLink><br />Genes Brain Behav. 2003 Oct;2(5):255-67. (PMID: <searchLink fieldCode="PM" term="%2214606691%22">14606691)</searchLink>
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  Data: JP24H01558 Ministry of Education, Culture, Sports, Science and Technology; JP18H05523 Ministry of Education, Culture, Sports, Science and Technology; JP20K14262 Japan Society for the Promotion of Science; 2021 Meiji Yasuda Mental Health Foundation
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  Data: <i>Keywords: </i>Anxiety; Autism spectrum disorder; Sensory over-responsivity; Sensory processing; fMRI
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        Text: English
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        Type: general
      – SubjectFull: Amygdala physiopathology
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      – SubjectFull: Brain physiopathology
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      – TitleFull: The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study.
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              Text: 2025 May 21
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