Academic Journal
The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study.
| Τίτλος: | The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study. |
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| Συγγραφείς: | Atsumi T; Department of Medical Physiology, Kyorin University, Tokyo, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp.; Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp., Ide M; Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan., Chakrabarty M; Department of Social Sciences and Humanities, Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India.; Centre for Design and New Media, Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India., Terao Y; Department of Medical Physiology, Kyorin University, Tokyo, Japan. |
| Πηγή: | Scientific reports [Sci Rep] 2025 May 21; Vol. 15 (1), pp. 17674. Date of Electronic Publication: 2025 May 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Autism Spectrum Disorder*/physiopathology , Autism Spectrum Disorder*/psychology , Autism Spectrum Disorder*/diagnostic imaging , Anxiety*/physiopathology , Time Perception*/physiology, Emotions/physiology ; Amygdala/physiopathology ; Brain/physiopathology ; Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Female ; Young Adult ; Adult ; Facial Expression ; Adolescent ; Brain Mapping |
| Περίληψη: | The atypical sensory features and high comorbidity of anxiety disorders in individuals with autism spectrum disorder (ASD) are attracting increasing attention. Among individuals with ASD, those who exhibit heightened sensory hyperresponsiveness tend to show enhanced temporal processing of sensory stimuli, despite no observed differences in stimulus detection thresholds. A previous study reported the role of anxiety in modulating emotion-cued changes of visual temporal resolution in ASD. Building on this, we hypothesized that elevated anxiety might contribute to increased activation of neural circuits for timing perception and sensory hyperresponsiveness. This study included 25 individuals with ASD and 25 typically developed (TD) participants. Using functional magnetic resonance imaging (fMRI), we examined neural activity during a visual temporal order judgment task pre-cued by facial emotions. In the TD group, but not the ASD group, the presence of fearful facial expressions enhanced temporal processing. However, a correlation of anxiety levels with emotion-cued task performance and sensory hyperresponsiveness, respectively, was evident in the ASD group. In the TD group, neuroimaging revealed greater activation of the right caudate compared with that in the ASD group and a functional connectivity between the amygdala and left supramarginal gyrus. Individuals with ASD showed a relationship between anxiety level and activation of the right angular gyrus. Moreover, anxiety mediated the link between right angular gyrus activation and sensory hyperresponsiveness in the ASD group. These findings suggest that enhancement of temporal processing by fear-related cues-reflecting an emotion-timing neural circuit-may be disrupted in individuals with ASD. Heightened anxiety and sensory hyperresponsiveness in ASD may be mediated by brain regions involved in timing perception. (© 2025. The Author(s).) |
| Competing Interests: | Competing interests: The authors declare no competing interests. Ethics approval: This study was reviewed and approved by the ethics committee of Kyorin University and the National Rehabilitation Center for Persons with Disabilities. This study was carried out in accordance with the Declaration of Helsinki and the guidelines for human research of both institutes. Written informed consent to participate in this study was provided by the participants themselves. Written informed consent was obtained from the individual(s) for publication of any potentially identifiable images or data included in this manuscript. |
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| Grant Information: | JP24H01558 Ministry of Education, Culture, Sports, Science and Technology; JP18H05523 Ministry of Education, Culture, Sports, Science and Technology; JP20K14262 Japan Society for the Promotion of Science; 2021 Meiji Yasuda Mental Health Foundation |
| Contributed Indexing: | Keywords: Anxiety; Autism spectrum disorder; Sensory over-responsivity; Sensory processing; fMRI |
| Entry Date(s): | Date Created: 20250521 Date Completed: 20250521 Latest Revision: 20250524 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12095537 |
| DOI: | 10.1038/s41598-025-02117-5 |
| PMID: | 40399452 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-02117-5 |