Academic Journal
Four new cytotoxic triterpenoids from Euphorbia fischeriana.
| Τίτλος: | Four new cytotoxic triterpenoids from Euphorbia fischeriana. |
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| Συγγραφείς: | He YB; Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China., Ma YN; Kunming Municipal Hospital of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, China., Huang YP; Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China., Li WN; Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China., Shi TX; Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China., Yang J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China., Zhao Y; Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Jul; Vol. 40 (14), pp. 4136-4146. Date of Electronic Publication: 2025 May 16. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Euphorbia*/chemistry , Triterpenes*/chemistry , Triterpenes*/isolation & purification , Triterpenes*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/isolation & purification, Humans ; Molecular Structure ; MCF-7 Cells ; Drug Screening Assays, Antitumor ; Inhibitory Concentration 50 ; A549 Cells |
| Περίληψη: | Our ongoing phytochemical investigation on Euphorbia fischeriana led to isolation of four new cytotoxic triterpenoids (1-4), along with twenty three known analogues (5-27). The new structures were characterised as fiseuphanins C-F (1-4) by NMR and HRESIMS spectroscopic experiments. Among them, isolates 8-15, 17-20, 22, and 25-27 were the first examples from E. fischeriana. Compounds 2, 11, and 13 exhibited significant cytotoxic activity against MCF-7 cell line with IC |
| Contributed Indexing: | Keywords: Euphorbia fischeriana; Euphorbiaceae; cytotoxicity; triterpenoids |
| Substance Nomenclature: | 0 (Triterpenes) 0 (Antineoplastic Agents, Phytogenic) |
| Entry Date(s): | Date Created: 20250516 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| DOI: | 10.1080/14786419.2025.2503015 |
| PMID: | 40378412 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2025.2503015 |