Academic Journal
Anti-biopassivated Reticular Micromotors for Bladder Cancer Therapy.
| Τίτλος: | Anti-biopassivated Reticular Micromotors for Bladder Cancer Therapy. |
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| Συγγραφείς: | Sun J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Chu R; Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan 250021, China., Wu X; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Yu Q; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Xiao W; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ao H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wang Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu T; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ju H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Lei J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. |
| Πηγή: | Journal of the American Chemical Society [J Am Chem Soc] 2025 May 28; Vol. 147 (21), pp. 17936-17945. Date of Electronic Publication: 2025 May 16. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
| Imprint Name(s): | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| Ιατρικοί όροι (MeSH): | Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Urease*/metabolism , Urease*/chemistry , Metal-Organic Frameworks*/chemistry , Metal-Organic Frameworks*/pharmacology , Metal-Organic Frameworks*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Urea/metabolism ; Urea/chemistry ; Humans ; Hydrogen Bonding ; Cell Line, Tumor |
| Περίληψη: | The limited lifespan of enzyme-powered micro/nanomotors (MNMs) hinders their biomedical applications due to the easy deactivation in tumor microenvironments. In this study, by taking advantage of hydrogen bond-rich metal-organic frameworks (MOFs), we design anti-biopassivated urease-powered MOF motors (Ur-MOFtors) with sustained motility for bladder cancer therapy. Such reticular Ur-MOFtors exhibited an exceptionally long locomotion lifespan exceeding 90 min in highly concentrated urea, which was an 18-fold enhancement compared with urease-adsorbed MOFs, resulting in excellent anti-biopassivation of MOFtors. The underlying molecular mechanism of persistent motion involves hydrogen bonding interaction between the MOF skeleton and the catalytic product, as identified by in situ infrared spectroscopy and density functional theory. Based on the preserved enzymatic activity comparable to native urease, the self-propulsion pathway of Ur-MOFtors is driven by ionic self-diffusiophoresis with the positive chemotactic motion toward urea. Benefiting from the persistent motion of Ur-MOFtors in physiological urea, a rapid bladder cancer therapy was achieved with few instillation sessions and short treatment cycles during intravesical administration. This hydrogen bond-rich framework presents a promising anti-biopassivated approach to overcoming the short lifespan and easy deactivation of enzymatic motors for advanced therapeutic robotics. |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Metal-Organic Frameworks) 8W8T17847W (Urea) 0 (Antineoplastic Agents) |
| Entry Date(s): | Date Created: 20250516 Date Completed: 20250528 Latest Revision: 20260722 |
| Update Code: | 20260722 |
| DOI: | 10.1021/jacs.5c02949 |
| PMID: | 40378338 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1520-5126 |
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| DOI: | 10.1021/jacs.5c02949 |