Academic Journal
A Neural Signature of Touch Aversion and Interpersonal Problems in Borderline Personality Disorder.
| Τίτλος: | A Neural Signature of Touch Aversion and Interpersonal Problems in Borderline Personality Disorder. |
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| Συγγραφείς: | Voelter J; Department of Psychiatry, School of Medicine and Health Sciences, University of Oldenburg, Oldenburg, Germany.; Ambulatory Assessment in Psychology, Department of Psychology, University of Oldenburg, Oldenburg, Germany., Postin D; Department of Psychiatry, School of Medicine and Health Sciences, University of Oldenburg, Oldenburg, Germany., Croy I; Department of Clinical Psychology, Institute of Psychology, Friedrich-Schiller-Universität Jena, Jena, Germany.; German Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Jena, Germany., Hurlemann R; Department of Psychiatry, School of Medicine and Health Sciences, University of Oldenburg, Oldenburg, Germany.; Research Center Neurosensory Science, University of Oldenburg, Oldenburg, Germany., Scheele D; Department of Social Neuroscience, Faculty of Medicine, Ruhr University Bochum, Bochum, Germany.; Research Center One Health Ruhr of the University Alliance Ruhr, Ruhr University Bochum, Bochum, Germany. |
| Πηγή: | Psychotherapy and psychosomatics [Psychother Psychosom] 2025; Vol. 94 (5), pp. 358-372. Date of Electronic Publication: 2025 May 11. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0024046 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0348 (Electronic) Linking ISSN: 00333190 NLM ISO Abbreviation: Psychother Psychosom Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel : Karger |
| Ιατρικοί όροι (MeSH): | Borderline Personality Disorder*/physiopathology , Borderline Personality Disorder*/therapy , Borderline Personality Disorder*/psychology , Touch*/physiology , Touch Perception*/physiology , Insular Cortex*/physiopathology , Insular Cortex*/diagnostic imaging , Interpersonal Relations*, Humans ; Female ; Adult ; Magnetic Resonance Imaging ; Male ; Dialectical Behavior Therapy ; Young Adult ; Case-Control Studies |
| Περίληψη: | Introduction: Patients with borderline personality disorder (BPD) suffer from severe social impairments and interpersonal problems. Social touch can provide comfort and facilitate the maintenance of social bonds, and preliminary evidence indicates a negative evaluation of social touch in patients with BPD. However, the neural mechanisms underlying aberrant touch processing in BPD and its role for social impairments are still unclear. Methods: We recruited 55 BPD patients and 31 healthy controls and used functional magnetic resonance imaging to probe neural responses to slow (i.e., C-tactile [CT]-optimal; affective) and fast (i.e., CT-suboptimal; discriminative) touch before and after 4 weeks of a residential dialectical behavior therapy (DBT) program. In addition to assessing BPD symptoms and interpersonal problems, we evaluated touch allowance maps and the attitude toward social touch. Results: BPD patients showed a comprehensive negative bias toward social touch before the DBT, evident in a significantly more negative attitude toward and reduced comfort zones of social touch compared to healthy controls. Activation in the posterior insular cortex in response to CT-optimal touch was significantly reduced and correlated with the severity of interpersonal problems in BPD patients. Despite significant improvements in overall BPD symptom load, dysfunctional social touch processing persisted after 4 weeks of DBT, indicating trait-like disturbances in BPD. Conclusions: An impaired insula-mediated integration of affective and sensory components of touch may constitute a clinically relevant biological signature of the complex interpersonal problems in BPD. (© 2025 S. Karger AG, Basel.) |
| Contributed Indexing: | Keywords: Borderline personality disorder; Dialectical behavior therapy; Functional magnetic resonance imaging; Interpersonal problems; Social touch |
| Entry Date(s): | Date Created: 20250511 Date Completed: 20251006 Latest Revision: 20260323 |
| Update Code: | 20260324 |
| DOI: | 10.1159/000545973 |
| PMID: | 40349695 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1423-0348 |
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| DOI: | 10.1159/000545973 |