Dual-functional silver-based metal-organic frameworks facilitate electrochemical/electrochemiluminescent dual-channel detection of chloride ions and glutathione.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Dual-functional silver-based metal-organic frameworks facilitate electrochemical/electrochemiluminescent dual-channel detection of chloride ions and glutathione.
Συγγραφείς:	Li W; College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China., Zhong Y; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China., Zhou P; College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China., Li P; College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China. Electronic address: lipp65@163.com., Huang S; Department of Orthopedics, Hunan Provincial People's Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha, 410005, China., Zhu X; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China., Zhang Y; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China., Liu M; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China. Electronic address: liuml@hunnu.edu.cn., Yao S; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China.
Πηγή:	Talanta [Talanta] 2025 Nov 01; Vol. 294, pp. 128278. Date of Electronic Publication: 2025 May 05.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
Imprint Name(s):	Publication: Amsterdam : Elsevier Original Publication: Oxford : Pergamon Press
Ιατρικοί όροι (MeSH):	Glutathione/analysis , Metal-Organic Frameworks/chemistry , Silver/chemistry , Electrochemical Techniques/methods , Chlorides/analysis , Luminescent Measurements/methods, Silver Compounds/chemistry ; Graphite/chemistry ; Nitrogen Compounds/chemistry ; Limit of Detection ; Humans
Περίληψη:	The early diagnosis of diseases largely relies on the monitoring and accurate detection of biomarkers within biological systems. The quantification of chloride ions (Cl^-) and glutathione (GSH) can effectively assess the progression of diseases such as cystic fibrosis and cancer, as well as the alterations in the body's internal environment. However, developing reliable sensing platforms with high sensitivity and selectivity poses significant challenges. Based on the dual-functional silver-based metal-organic frameworks (Ag MOF), an electrochemical/electrochemiluminescent (EC/ECL) dual-channel nanoplatform was developed for the detection of Cl^- and GSH, aided by graphitic carbon nitride (g-C3N4). In the EC mode, the interaction between Ag MOF and Cl^- leads to the formation of silver chloride (AgCl), which is characterized by an increased peak current of AgCl solid-state electrochemistry as Cl^- concentration rises. The further introduction of GSH generates a non-electroactive complex through competition with Cl^-, resulting in a decrease in the peak current of AgCl. In the ECL mode, the quenching of ECL signals from g-C3N4 by Ag MOF is alleviated by Cl^-, due to the etching of the Ag-MOF. The ECL recovery effect is further enhanced with the addition of GSH. For Cl^-, both EC and ECL responses exhibit good linear relationships with concentrations ranging from 0.5 to 10 mM, with detection limit (LOD) of 0.4 mM and 0.1 mM, respectively. For GSH, EC and ECL also show good linear relationships in range of 0.01-100 μM, with LOD of 9.8 nM and 1.02 nM. The unique properties of Ag MOF, acting both as an electrochemical sensing component that generates sensitive current outputs for Cl^- and GSH, and as a quencher for the ECL of g-C3N4, facilitate the sequential detection of Cl^- and GSH, providing mutual validation that significantly enhances accuracy and reliability. The specific interactions of Ag MOF with these analytes offer the innovative platform good selectivity, demonstrating significant potential for advancements in biological analysis and disease diagnosis. (Copyright © 2025 Elsevier B.V. All rights reserved.)
Competing Interests:	Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing:	Keywords: Chloride ions; Electrochemiluminescence; Electrochemistry; Glutathione; Graphitic carbon nitride; Silver based metal-organic framework
Substance Nomenclature:	GAN16C9B8O (Glutathione) 0 (Metal-Organic Frameworks) 3M4G523W1G (Silver) 0 (Chlorides) MWB0804EO7 (silver chloride) 0 (Silver Compounds) 0 (graphitic carbon nitride) 7782-42-5 (Graphite) 0 (Nitrogen Compounds)
Entry Date(s):	Date Created: 20250507 Date Completed: 20250603 Latest Revision: 20250603
Update Code:	20260130
DOI:	10.1016/j.talanta.2025.128278
PMID:	40334507
Βάση Δεδομένων:	MEDLINE

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Περιγραφή
ISSN:	1873-3573
DOI:	10.1016/j.talanta.2025.128278