Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Proteomic Analysis of Marine Bacteriophages: Structural Conservation, Post-Translational Modifications, and Phage-Host Interactions.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Proteomic Analysis of Marine Bacteriophages: Structural Conservation, Post-Translational Modifications, and Phage-Host Interactions.
Συγγραφείς: Wei S; State Key Laboratory of Marine Geology, Tongji University, Shanghai, China.; Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, China., Wang A; State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China., Cai L; Earth, Ocean and Atmospheric Sciences Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China., Ma R; Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, China., Lu L; Fourth Institute of Oceanography, Ministry of Natural Resources, Beihai, China., Li J; State Key Laboratory of Marine Geology, Tongji University, Shanghai, China., Zhang R; Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, China.
Πηγή: Environmental microbiology [Environ Microbiol] 2025 Apr; Vol. 27 (4), pp. e70099.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: England NLM ID: 100883692 Publication Model: Print Cited Medium: Internet ISSN: 1462-2920 (Electronic) Linking ISSN: 14622912 NLM ISO Abbreviation: Environ Microbiol Subsets: MEDLINE
Imprint Name(s): Original Publication: Oxford : Blackwell Science, 1999-
Ιατρικοί όροι (MeSH): Bacteriophages*/genetics , Bacteriophages*/chemistry , Bacteriophages*/physiology , Bacteriophages*/metabolism , Viral Proteins*/genetics , Viral Proteins*/metabolism , Viral Proteins*/chemistry , Seawater*/virology , Protein Processing, Post-Translational* , Host Microbial Interactions* , Proteome*, Aquatic Organisms/virology ; Proteomics
Περίληψη: Marine bacteriophages, the most abundant biological entities in marine ecosystems, are essential in biogeochemical cycling. Despite extensive genomic data, many phage genes remain uncharacterised, creating a gap between genomic diversity and gene function knowledge. This gap limits our understanding of phage life cycles, assembly, and host interactions. In this study, we used mass spectrometry to profile the proteomes of 13 marine phages from diverse lifestyles and hosts. The analysis accurately annotated hypothetical genes, mapped virion protein arrangements, and revealed structural similarities among phages infecting the same host, particularly in tail fibre proteins. Protein structure comparisons showed conservation and variability in head and tail proteins, particularly in key domains involved in virion stabilisation and host recognition. For the first time, we identified post-translational modifications (PTMs) in marine phage proteins, which may enhance phage adaptability and help evade host immune systems. These findings suggest that phages optimise their infection strategies through structural variations and PTM modifications, improving their adaptability and host interactions.
(© 2025 The Author(s). Environmental Microbiology published by John Wiley & Sons Ltd.)
References: Viruses. 2019 Apr 01;11(4):. (PMID: 30939832)
Appl Environ Microbiol. 2011 Dec;77(23):8265-71. (PMID: 21965409)
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10174-9. (PMID: 27555589)
Virol Sin. 2019 Oct;34(5):549-562. (PMID: 31134586)
J Virol. 2014 Jan;88(2):820-8. (PMID: 24155371)
EMBO J. 2007 Apr 4;26(7):1984-94. (PMID: 17363899)
Nat Rev Microbiol. 2012 Jun 11;10(7):472-82. (PMID: 22683880)
Environ Microbiol. 2015 Nov;17(11):4239-52. (PMID: 25472545)
Structure. 2018 Feb 6;26(2):238-248.e3. (PMID: 29290487)
Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1336-45. (PMID: 24816102)
Nat Commun. 2020 Jun 15;11(1):3034. (PMID: 32541663)
Curr Opin Struct Biol. 2014 Apr;25:1-8. (PMID: 24878339)
Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2654-9. (PMID: 26929357)
Nucleic Acids Res. 2014 Jan;42(Database issue):D206-14. (PMID: 24293654)
Cell Host Microbe. 2022 Nov 9;30(11):1556-1569.e5. (PMID: 36302390)
Nat Protoc. 2015 Jun;10(6):845-58. (PMID: 25950237)
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8184-E8193. (PMID: 28893988)
J Mol Biol. 1996 May 24;258(5):726-31. (PMID: 8637004)
Mar Genomics. 2015 Aug;22:15-7. (PMID: 25795023)
Annu Rev Virol. 2019 Sep 29;6(1):141-160. (PMID: 31337287)
Nat Commun. 2017 Dec 5;8(1):1953. (PMID: 29209037)
Virol J. 2012 Jan 25;9:32. (PMID: 22273269)
Cell. 2023 Feb 16;186(4):864-876.e21. (PMID: 36750095)
Nat Commun. 2019 May 30;10(1):2366. (PMID: 31147544)
Chem Soc Rev. 2012 May 21;41(10):3912-28. (PMID: 22498958)
J Mol Biol. 2013 May 27;425(10):1731-44. (PMID: 23434847)
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8. (PMID: 15980461)
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2436-41. (PMID: 26884177)
Microbiol Mol Biol Rev. 2000 Mar;64(1):69-114. (PMID: 10704475)
Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3601-3606. (PMID: 28320961)
Viruses. 2015 Sep 18;7(9):5084-114. (PMID: 26393641)
J Virol. 2013 Nov;87(22):12302-12. (PMID: 24027307)
J Bacteriol. 1991 Oct;173(20):6507-14. (PMID: 1917875)
Nat Commun. 2023 Jun 17;14(1):3609. (PMID: 37330604)
Nat Commun. 2019 Aug 20;10(1):3746. (PMID: 31431626)
Trends Microbiol. 2019 Jan;27(1):51-63. (PMID: 30181062)
Nat Methods. 2015 Jan;12(1):7-8. (PMID: 25549265)
Nature. 2020 Apr;580(7805):658-662. (PMID: 32350467)
Virus Evol. 2017 Dec 07;3(2):vex036. (PMID: 29250433)
FEMS Microbiol Rev. 2004 May;28(2):127-81. (PMID: 15109783)
Avian Dis. 2013 Jun;57(2 Suppl):351-9. (PMID: 23901746)
Nature. 2022 Dec;612(7938):132-140. (PMID: 36385533)
Science. 2018 Mar 2;359(6379):. (PMID: 29371424)
Nat Rev Microbiol. 2023 Oct;21(10):686-700. (PMID: 37460672)
ISME J. 2015 Sep;9(9):2094-107. (PMID: 26125682)
Virol J. 2019 Nov 6;16(1):128. (PMID: 31694663)
Bioinformatics. 2023 Jan 1;39(1):. (PMID: 36453861)
Cell. 2019 Oct 3;179(2):459-469.e9. (PMID: 31585083)
Front Microbiol. 2022 May 10;13:861793. (PMID: 35620087)
Cell Mol Life Sci. 2003 Nov;60(11):2356-70. (PMID: 14625682)
Nat Rev Mol Cell Biol. 2019 Mar;20(3):156-174. (PMID: 30467427)
Virol J. 2017 Jun 7;14(1):104. (PMID: 28592325)
Nature. 1999 Jun 10;399(6736):541-8. (PMID: 10376593)
Nat Microbiol. 2022 Nov;7(11):1849-1856. (PMID: 36192536)
Viruses. 2016 Jan 21;8(1):. (PMID: 26805872)
Nature. 2019 Jun;570(7760):257-261. (PMID: 31142842)
Front Microbiol. 2019 Aug 22;10:1876. (PMID: 31507544)
Plant Cell Environ. 2021 Jun;44(6):1707-1715. (PMID: 33506956)
Environ Microbiol. 2018 Feb;20(2):477-491. (PMID: 28925544)
EMBO J. 2015 Jan 13;34(2):169-83. (PMID: 25452498)
Viruses. 2017 May 15;9(5):. (PMID: 28505134)
Nat Commun. 2020 Nov 13;11(1):5759. (PMID: 33188213)
Cell. 2019 May 16;177(5):1109-1123.e14. (PMID: 31031001)
Nat Rev Microbiol. 2020 Mar;18(3):125-138. (PMID: 32015529)
Front Immunol. 2021 Apr 29;12:638573. (PMID: 33995356)
PLoS One. 2017 Feb 16;12(2):e0172303. (PMID: 28207864)
BMC Microbiol. 2011 Sep 26;11:213. (PMID: 21943085)
Nucleic Acids Res. 2021 Jan 8;49(D1):D412-D419. (PMID: 33125078)
Glycobiology. 2021 Jan 9;31(1):69-80. (PMID: 32518941)
Genes Cells. 2018 Jul;23(7):528-536. (PMID: 29767456)
Mol Cell Proteomics. 2022 Dec;21(12):100425. (PMID: 36241021)
Front Microbiol. 2016 May 18;7:745. (PMID: 27242758)
Curr Opin Virol. 2019 Jun;36:9-16. (PMID: 30856581)
Proteome Sci. 2008 Mar 17;6:11. (PMID: 18346272)
J Mol Biol. 2008 May 2;378(3):726-36. (PMID: 18374942)
Nucleic Acids Res. 2013 Jan;41(Database issue):D348-52. (PMID: 23197659)
J Immunol. 2013 Mar 1;190(5):2169-77. (PMID: 23365085)
Nature. 2005 Sep 15;437(7057):356-61. (PMID: 16163346)
Mol Microbiol. 2016 Jan;99(1):188-98. (PMID: 26395283)
J Struct Biol. 2017 Dec;200(3):343-359. (PMID: 28842338)
Appl Environ Microbiol. 2016 May 16;82(11):3165-73. (PMID: 26994078)
Viruses. 2015 Jun 24;7(7):3361-79. (PMID: 26114474)
J Mol Biol. 2003 Dec 12;334(5):885-99. (PMID: 14643655)
Structure. 2012 Mar 7;20(3):498-503. (PMID: 22405008)
Nat Struct Mol Biol. 2019 Apr;26(4):308-314. (PMID: 30936526)
Mol Cell. 2005 Apr 15;18(2):149-59. (PMID: 15837419)
Nat Commun. 2022 May 10;13(1):2561. (PMID: 35538097)
Sci Rep. 2023 Dec 5;13(1):21426. (PMID: 38052835)
Cell. 2021 Nov 11;184(23):5728-5739.e16. (PMID: 34644530)
Nat Med. 2012 Nov;18(11):1688-92. (PMID: 23086475)
Structure. 2018 Dec 4;26(12):1565-1567. (PMID: 30517883)
Elife. 2013 Dec 17;2:e01299. (PMID: 24347545)
Grant Information: Synthetic Biology Research Center of Shenzhen University; 2023M742393 China Postdoctoral Science Foundation; 2023KCXTD028 Innovation Team Project of Universities in Guangdong Province; 2023B0303000017 Guangdong Major Project of Basic and Applied Basic Research
Contributed Indexing: Keywords: marine viruses; phage–host interactions; post‐translational modifications; proteomic
Substance Nomenclature: 0 (Viral Proteins)
0 (Proteome)
Entry Date(s): Date Created: 20250422 Date Completed: 20250423 Latest Revision: 20250425
Update Code: 20260130
PubMed Central ID: PMC12014285
DOI: 10.1111/1462-2920.70099
PMID: 40262907
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1462-2920
DOI:10.1111/1462-2920.70099