Academic Journal
Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Patients With Emotion Dysregulation.
| Τίτλος: | Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Patients With Emotion Dysregulation. |
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| Συγγραφείς: | Saccaro LF; Psychiatry Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Psychiatry Department, Geneva University Hospital, Geneva, Switzerland; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Medical Image Processing Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland. Electronic address: luigi.saccaro@epfl.ch., Delavari F; Medical Image Processing Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland., Meuleman B; Psychiatry Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland., Perroud N; Psychiatry Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Psychiatry Department, Geneva University Hospital, Geneva, Switzerland., Van De Ville D; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Medical Image Processing Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland., Piguet C; Psychiatry Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland; General Pediatric Division, Geneva University Hospital, Geneva, Switzerland. |
| Πηγή: | Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2026 Aug; Vol. 11 (8), pp. 912-922. Date of Electronic Publication: 2025 Mar 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Elsevier, Inc., [2016]- |
| Ιατρικοί όροι (MeSH): | Hippocampus*/physiopathology , Hippocampus*/diagnostic imaging , Borderline Personality Disorder*/physiopathology , Limbic System*/physiopathology , Limbic System*/diagnostic imaging , Sensorimotor Cortex*/physiopathology , Sensorimotor Cortex*/diagnostic imaging , Affective Symptoms*/physiopathology , Affective Symptoms*/diagnostic imaging , Emotional Regulation*/physiology , Child of Impaired Parents*, Bipolar Disorder/physiopathology ; Neural Pathways/physiopathology ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Humans ; Female ; Magnetic Resonance Imaging ; Male ; Adult ; Young Adult ; Adolescent |
| Περίληψη: | Background: Emotion dysregulation (ED) is a key transdiagnostic symptom in several psychiatric disorders such as borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These disorders, defined herein as ED disorders (EDDs), share similarities in symptoms, comorbidity, and heritability, emphasizing the importance of a transdiagnostic approach to identify markers of vulnerability to EDDs in high-risk populations, such as the offspring of patients with an EDD (EDDoff). The hippocampus, central to ED, exhibits alterations across EDDs. Methods: We used a state-of-the-art approach (micro-coactivation patterns [μCAPs]) to study the transdiagnostic dynamic functional connectivity (dFC) of hippocampal subregions from resting-state functional magnetic resonance imaging of 201 participants (74 patients with an EDD, 57 EDDoff, 70 healthy control participants). μCAPs provide a data-driven differentiation within the seed region. Results: dFC between the sensorimotor network (SMN) and the hippocampal body was lower in patients with EDDs (false discovery rate [FDR]-corrected p = .0002) and in EDDoff (p Conclusions: Increased dFC between the hippocampal head and the LN, at the expense of the SMN, may represent a marker of disease in patients with EDDs. Lower dFC between the SMN and the hippocampal body may represent a marker of vulnerability to EDDs in EDDoff that is correlated with ED. Such a transdiagnostic construct represents a clinically relevant target for early interventions aimed at reducing vulnerability to EDDs in high-risk populations. (Copyright © 2025 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: ADHD; Bipolar disorder; Borderline personality disorder; High risk; Magnetic resonance imaging; Offspring |
| Entry Date(s): | Date Created: 20250330 Date Completed: 20260806 Latest Revision: 20260806 |
| Update Code: | 20260807 |
| DOI: | 10.1016/j.bpsc.2025.03.007 |
| PMID: | 40158696 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2451-9030 |
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| DOI: | 10.1016/j.bpsc.2025.03.007 |