Academic Journal
Neonatal Mortality Due to Early-Onset Sepsis in Eastern Europe: A Review of Current Monitoring Protocols During Pregnancy and Maternal Demographics in Eastern Europe, with an Emphasis on Romania-Comparison with Data Extracted from a Secondary Center in Southern Romania.
| Τίτλος: | Neonatal Mortality Due to Early-Onset Sepsis in Eastern Europe: A Review of Current Monitoring Protocols During Pregnancy and Maternal Demographics in Eastern Europe, with an Emphasis on Romania-Comparison with Data Extracted from a Secondary Center in Southern Romania. |
|---|---|
| Συγγραφείς: | Vulcănescu A; 'Filantropia' Clinical Municipal Hospital, 200143 Craiova, Romania.; University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Siminel MA; 'Filantropia' Clinical Municipal Hospital, 200143 Craiova, Romania.; Department of Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Dinescu SN; Department of Epidemiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Clinical Emergency County Hospital, 200642 Craiova, Romania., Dijmărescu AL; 'Filantropia' Clinical Municipal Hospital, 200143 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Manolea MM; 'Filantropia' Clinical Municipal Hospital, 200143 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Săndulescu SM; 'Filantropia' Clinical Municipal Hospital, 200143 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. |
| Πηγή: | Children (Basel, Switzerland) [Children (Basel)] 2025 Mar 13; Vol. 12 (3). Date of Electronic Publication: 2025 Mar 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101648936 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9067 (Print) Linking ISSN: 22279067 NLM ISO Abbreviation: Children (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2014]- |
| Περίληψη: | Neonatal mortality, particularly due to early-onset sepsis (EOS), remains a pressing issue in Eastern Europe, with Romania experiencing one of the highest neonatal mortality rates in the European Union. EOS, caused by bacterial infections within the first 72 h of life, significantly contributes to neonatal deaths, particularly in rural and underserved areas where healthcare resources are limited. Disparities in prenatal care access, maternal demographics, and systemic healthcare gaps worsen this issue, highlighting the need for comprehensive interventions. Objectives: This review aims to examine the prevalence of neonatal mortality due to EOS in Romania and the broader Eastern European context, focusing on current prenatal care monitoring protocols and maternal demographics, and comparing the available literature with new data. By evaluating disparities in healthcare access, costs, and outcomes, this study identifies systemic barriers to maternal and neonatal care. Methods: A systematic review of 100 articles was conducted using PRISMA guidelines. Key sources included PubMed, Google Scholar, and open-access journals, with 25 articles meeting the inclusion criteria. The analysis encompassed maternal age, parity, literacy levels, marital status, and their impact on neonatal outcomes, alongside the financial burden of prenatal care. Results: The findings underscore stark inequalities in healthcare delivery between rural and urban regions, where limited prenatal visits, out-of-pocket costs, and cultural barriers hinder prompt EOS prevention and management. Advanced maternal age, low literacy, and socioeconomic disparities were identified as critical risk factors. Conclusions: To reduce neonatal mortality due to EOS, targeted efforts must address healthcare accessibility, improve prenatal care protocols, and integrate culturally sensitive practices. These interventions can bridge systemic gaps and promote equitable health outcomes for mothers and newborns across Eastern Europe. |
| References: | Am J Prev Med. 2001 Jul;21(1):52-9. (PMID: 11418258) BMJ. 2021 Mar 29;372:n71. (PMID: 33782057) Hypertens Pregnancy. 2020 Nov;39(4):423-428. (PMID: 32758043) Diagnostics (Basel). 2022 Sep 01;12(9):. (PMID: 36140531) J Immigr Minor Health. 2014 Aug;16(4):719-23. (PMID: 23616047) Vaccine. 2013 Aug 28;31 Suppl 4:D43-5. (PMID: 23973346) BMC Pediatr. 2019 Dec 12;19(1):490. (PMID: 31830941) Int J Environ Res Public Health. 2021 May 21;18(11):. (PMID: 34063905) Eur J Contracept Reprod Health Care. 2014 Jun;19(3):220-6. (PMID: 24836590) Medicina (Kaunas). 2022 May 26;58(6):. (PMID: 35743972) Acta Obstet Gynecol Scand. 2008;87(3):260-71. (PMID: 18307064) |
| Contributed Indexing: | Keywords: Eastern Europe; maternal demographics; monitoring protocols; neonatal mortality |
| Entry Date(s): | Date Created: 20250328 Latest Revision: 20250330 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11941689 |
| DOI: | 10.3390/children12030354 |
| PMID: | 40150636 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2227-9067 |
|---|---|
| DOI: | 10.3390/children12030354 |