Academic Journal
Prehospital β₂-agonist administration via spacer versus nebuliser.
| Τίτλος: | Prehospital β₂-agonist administration via spacer versus nebuliser. |
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| Συγγραφείς: | Christiansen CD; Department of Emergency Medicine and Trauma Centre, Aalborg University Hospital., Nielsen MTK; Research Unit for Clinical Microbiology, Department of Clinical Diagnostics, University Hospital Southern Denmark, Esbjerg., Søltoft JL; Emergency Medical Services, Region North, Aalborg., Christensen EF; Department of Clinical Medicine, Aalborg University.; Centre for Prehospital and Emergency Research, Aalborg University Hospital., Krarup AL; Department of Emergency Medicine and Trauma Centre, Aalborg University Hospital.; Department of Clinical Medicine, Aalborg University., Gamst J; Emergency Medical Services, Region North, Aalborg.; Department of Anesthesia and Intensive Care Medicine, Aalborg University Hospital, Denmark. |
| Πηγή: | Danish medical journal [Dan Med J] 2024 Jul 04; Vol. 71 (8). Date of Electronic Publication: 2024 Jul 04. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Danish Medical Association Country of Publication: Denmark NLM ID: 101576205 Publication Model: Electronic Cited Medium: Internet ISSN: 2245-1919 (Electronic) Linking ISSN: 22451919 NLM ISO Abbreviation: Dan Med J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Copenhagen : Danish Medical Association |
| Ιατρικοί όροι (MeSH): | Adrenergic beta-2 Receptor Agonists*/administration & dosage , Dyspnea*/drug therapy , Emergency Medical Services*/methods , Nebulizers and Vaporizers* , Inhalation Spacers*, Carbon Dioxide/blood ; Humans ; Male ; Female ; Middle Aged ; Denmark ; Aged ; Blood Gas Analysis ; Adult ; Administration, Inhalation ; Hydrogen-Ion Concentration ; Ambulances ; Vital Signs |
| Περίληψη: | Introduction: In 2021, administration of β₂-agonist in the ambulance changed from nebuliser to spacer in the North Denmark Region. We aimed to quantify the effectiveness of the switch by comparing 1) dyspnoea score, 2) median pCO2, pH, and paO2 and 3) vital signs. Methods: We conducted a quality assessment study including adults treated in the ambulance with a β₂-agonist from 2018 to 2022 in the North Denmark Region. Prehospital vital signs, dyspnoea scores (0-10) and medicine administration data were collected from the electronic prehospital medical record. Blood gas analyses were collected from the clinical laboratory information system. Results: A total of 6,521 patient encounters were included, 70% received β₂-agonist by nebuliser and 30% by spacer. Dyspnoea scores were recorded in 45%, arterial blood gas analysis in 62%. The median (interquartile range) last dyspnoea score was 4 (3-6) in both groups, p = 0.79. The nebuliser group had a higher median paCO2 (6.0 versus 5.8, p less-than 0.001), a lower pH (7.38 versus 7.40, p less-than 0.001), a higher paO2 (9.20 versus 9.00, p less-than 0.001), and a higher last measured mean pulse (99 versus 97, p = 0.001) than the spacer group. Conclusions: Patients receiving β₂-agonist by spacer had similar relief of dyspnoea as those who received the medicine by nebuliser. Patients using the nebuliser had a higher median paCO2, a lower pH and a higher pulse rate than patients using the spacer. Funding: None. Trial Registration: Hospitals and prehospital administration approval no. 2017-011259. Data collection registration no. K2022-073. (Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.) |
| Substance Nomenclature: | 0 (Adrenergic beta-2 Receptor Agonists) 142M471B3J (Carbon Dioxide) |
| Entry Date(s): | Date Created: 20250321 Date Completed: 20250321 Latest Revision: 20250514 |
| Update Code: | 20260130 |
| DOI: | 10.61409/A01240041 |
| PMID: | 40116450 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2245-1919 |
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| DOI: | 10.61409/A01240041 |