Academic Journal
Euphthymifolols A-E, anti-inflammatory jatrophane-type macrocyclic diterpenoids from Euphorbia thymifolia L.
| Τίτλος: | Euphthymifolols A-E, anti-inflammatory jatrophane-type macrocyclic diterpenoids from Euphorbia thymifolia L. |
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| Συγγραφείς: | Cao JY; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China., Liang CH; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China., Deng ZP; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China., Zhao P; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China., Liu YY; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China., Wang SJ; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Jun; Vol. 40 (12), pp. 3611-3618. Date of Electronic Publication: 2025 Mar 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Euphorbia*/chemistry , Diterpenes*/chemistry , Diterpenes*/pharmacology , Diterpenes*/isolation & purification , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/isolation & purification, Nitric Oxide/biosynthesis ; Nitric Oxide/antagonists & inhibitors ; Microglia/drug effects ; Lipopolysaccharides/pharmacology ; Plant Components, Aerial/chemistry ; Animals ; Molecular Structure ; Mice ; Cell Line |
| Περίληψη: | Euphthymifolols A-E (1-5), five undescribed jatrophane diterpenoids feature with a typically 5/12 bicyclic skeleton, were characterised from the aerial parts of Euphorbia thymifolia L. A thorough analysis of the spectroscopic data and biosynthetic pathway elucidated their planar structures and stereoconfiguration. Compound 4 exhibited moderate nitric oxide (NO) inhibitory activity (IC |
| Contributed Indexing: | Keywords: BV-2 microglial cell; Euphorbia thymifolia L; NO inhibitory activity; diterpenoid; jatrophane |
| Substance Nomenclature: | 0 (Diterpenes) 31C4KY9ESH (Nitric Oxide) 0 (Lipopolysaccharides) 0 (Anti-Inflammatory Agents) 0 (jatrophane) |
| Entry Date(s): | Date Created: 20250314 Date Completed: 20260613 Latest Revision: 20260613 |
| Update Code: | 20260615 |
| DOI: | 10.1080/14786419.2025.2478303 |
| PMID: | 40085800 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2025.2478303 |