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Dual-crosslinked zwitterionic hydrogel: a facile platform of wearable colorimetric urea sensors.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Dual-crosslinked zwitterionic hydrogel: a facile platform of wearable colorimetric urea sensors.
Συγγραφείς: Somchob B; Nanoscience and Technology Program, Graduate School, Chulalongkorn University, Bangkok, 10330, Thailand., Passornraprasit N; Department of Materials Science, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand., Hoven VP; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.; Center of Excellence in Materials and Bio-Interfaces, Chulalongkorn University, Bangkok, 10330, Thailand., Rodthongkum N; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Nadnudda.R@chula.ac.th.; Center of Excellence in Responsive Wearable Materials, Chulalongkorn University, Soi Chula 12, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. Nadnudda.R@chula.ac.th.
Πηγή: Mikrochimica acta [Mikrochim Acta] 2025 Mar 04; Vol. 192 (4), pp. 204. Date of Electronic Publication: 2025 Mar 04.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE
Imprint Name(s): Original Publication: Wien ; New York : Springer-Verlag.
Ιατρικοί όροι (MeSH): Urea*/analysis , Colorimetry*/methods , Colorimetry*/instrumentation , Hydrogels*/chemistry , Wearable Electronic Devices*, Urease/chemistry ; Urease/metabolism ; Methacrylates/chemistry ; Cross-Linking Reagents/chemistry ; Humans ; Limit of Detection
Περίληψη: Zwitterionic hydrogel based on a dual-crosslinked network of pluronic F-127 dimethacrylate (PLU-DMA) and a terpolymer, poly(sulfobetaine methacrylate)-co-methacrylic acid-co-N-methacryloyloxyethyl tyrosine methylester) (PSBMM) was prepared and successfully applied as an enzyme-based colorimetric sensor of urea on diaper. The prepared hydrogel possessed good mechanical property while preserving its swelling capability. The urease-incorporated hydrogel exhibited a vivid color change from yellow to orange and red, enabling semi-qualitative detection of urea via naked eye in a linear range of 0-0.7 M covering a cut-off value of 0.3 M, which allow for distinguishing between the chronic kidney-prone patients from the normal individuals. The hydrogel was found to be non-toxic and demonstrated effective enzyme preservation by maintaining more than 80% of urease activity up to 14 days. This hydrogel-based urea sensor was also validated by laser desorption ionization mass spectrometry (LDI-MS) with satisfactory results. This platform demonstrated its potential integration on diaper for real-time screening of urea in the point-of-care diagnostics of chronic kidney disease (CKD).
(© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
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Contributed Indexing: Keywords: Chronic kidney disease; Colorimetric sensor; Dual-crosslinked hydrogel; Urea; Zwitterionic polymer
Substance Nomenclature: 8W8T17847W (Urea)
0 (Hydrogels)
EC 3.5.1.5 (Urease)
0 (Methacrylates)
0 (Cross-Linking Reagents)
Entry Date(s): Date Created: 20250304 Date Completed: 20250304 Latest Revision: 20260630
Update Code: 20260630
DOI: 10.1007/s00604-025-07060-w
PMID: 40035872
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1436-5073
DOI:10.1007/s00604-025-07060-w