Academic Journal
From the atomic nucleus to cancer cure: The marvel of BNCT a nuclear physicist views. Achievements and outstanding problems.
| Τίτλος: | From the atomic nucleus to cancer cure: The marvel of BNCT a nuclear physicist views. Achievements and outstanding problems. |
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| Συγγραφείς: | Kreiner AJ; CNEA, Av. Gral Paz 1499, B1650KNA, San Martín, Prov. Buenos Aires, Argentina; Escuela de Ciencia y Tecnología-UNSAM, Martín de Irigoyen 3100, 1650, San Martín, Prov. Buenos Aires, Argentina; CONICET Av. Rivadavia 1917, C1033AAJ, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: andreskreiner@gmail.com. |
| Πηγή: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2025 Jun; Vol. 220, pp. 111725. Date of Electronic Publication: 2025 Feb 18. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford ; New York : Pergamon Press, c1993- |
| Ιατρικοί όροι (MeSH): | Boron Neutron Capture Therapy*/methods , Neoplasms*/radiotherapy , Nuclear Physics*, Humans |
| Περίληψη: | The interdisciplinary character of the BNCT endeavour is stressed ranging from nuclear physics to most of the natural and exact sciences. Radiobiology studies, carried out with accelerated proton, alpha and Li beams, are used to isolate the relative biological effectiveness of "pure" high LET radiation. Based on the survival curve results, we discuss the question of the use of fixed RBE factors to convert physical doses into equivalent or isoeffective gamma doses. Furthermore, the necessity of converting physical doses into equivalent or isoeffective gamma doses is questioned. Tumor Control Probabilities are discussed and used as a tool to optimize Beam Shaping Assemblies. Boron microdistribution studies are mentioned and the lack of a sufficiently complete method to cover the whole tumor, given the heterogeneity in 3D, is pointed out. The development of Prompt Gamma Single Photon Emission Computed Tomography, PG-SPECT, systems especially tailored for BNCT are discussed stressing them as a powerful way of determining in real time the macroscopic average boron dose delivered to the patient. Studies of deuteron-induced neutron-producing are reviewed and the development of electrostatic quadrupole technology for BNCT is highlighted. (Copyright © 2025 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Accelerator technology development; Beam shaping assembly optimization; Boron microdistribution studies; Deuteron induced reactions; Milestones in BNCT; PG-SPECT systems; Radiobiology studies |
| Entry Date(s): | Date Created: 20250227 Date Completed: 20250403 Latest Revision: 20260709 |
| Update Code: | 20260709 |
| DOI: | 10.1016/j.apradiso.2025.111725 |
| PMID: | 40014940 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-9800 |
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| DOI: | 10.1016/j.apradiso.2025.111725 |