Academic Journal
The unusual suspect: A novel role for intermediate filament proteins in mitochondrial morphology.
| Τίτλος: | The unusual suspect: A novel role for intermediate filament proteins in mitochondrial morphology. |
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| Συγγραφείς: | Hemel IMGM; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Steen C; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Denil SLIJ; Flemish Institute for Technological Research (VITO) 2400 Mol, Belgium., Ertaylan G; Flemish Institute for Technological Research (VITO) 2400 Mol, Belgium., Kutmon M; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Adriaens M; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Gerards M; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands. Electronic address: mike.gerards@maastrichtuniversity.nl. |
| Πηγή: | Mitochondrion [Mitochondrion] 2025 Mar; Vol. 81, pp. 102008. Date of Electronic Publication: 2025 Feb 03. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100968751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8278 (Electronic) Linking ISSN: 15677249 NLM ISO Abbreviation: Mitochondrion Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| Ιατρικοί όροι (MeSH): | Mitochondria*/metabolism , Vimentin*/metabolism , Vimentin*/genetics , Intermediate Filament Proteins*/metabolism , Intermediate Filament Proteins*/genetics , Mitochondrial Proteins*/metabolism , Mitochondrial Proteins*/genetics , Mitochondrial Dynamics*, Intermediate Filaments/metabolism ; Humans ; Protein Interaction Mapping |
| Περίληψη: | Mitochondrial dynamics is crucial for cellular homeostasis. However, not all proteins involved are known. Using a protein-protein interaction (PPI) approach, we identified ITPRIPL2 for involvement in mitochondrial dynamics. ITPRIPL2 co-localizes with intermediate filament protein vimentin, supported by protein simulations. ITPRIPL2 knockdown reveals mitochondrial elongation, disrupts vimentin processing, intermediate filament formation, and alters vimentin-related pathways. Interestingly, vimentin knockdown also leads to mitochondrial elongation. These findings highlight ITPRIPL2 as vimentin-associated protein essential for intermediate filament structure and suggest a role for intermediate filaments in mitochondrial morphology. Our study demonstrates that PPI analysis is a powerful approach for identifying novel mitochondrial dynamics proteins. (Copyright © 2025. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Intermediate filaments; Mitochondria; Mitochondrial dynamics; Network analysis; Protein-protein interactions |
| Substance Nomenclature: | 0 (Vimentin) 0 (Intermediate Filament Proteins) 0 (Mitochondrial Proteins) |
| Entry Date(s): | Date Created: 20250205 Date Completed: 20250505 Latest Revision: 20260717 |
| Update Code: | 20260718 |
| DOI: | 10.1016/j.mito.2025.102008 |
| PMID: | 39909388 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-8278 |
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| DOI: | 10.1016/j.mito.2025.102008 |