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Methylcobalamin-containing nanofiber sheets have better neuroprotective effects than small intestinal submucosa sheets.

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Τίτλος: Methylcobalamin-containing nanofiber sheets have better neuroprotective effects than small intestinal submucosa sheets.
Συγγραφείς: Yoshimura Y; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Iwahashi T; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Kasuya T; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Shimada T; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Konishi K; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Kamata A; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Konishi M; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Kazui A; Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, 2-2 amadaoka, Suita, Osaka, 565-0871, Japan., Shiode R; Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, 2-2 amadaoka, Suita, Osaka, 565-0871, Japan., Miyamura S; Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, 2-2 amadaoka, Suita, Osaka, 565-0871, Japan., Oka K; Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, 2-2 amadaoka, Suita, Osaka, 565-0871, Japan., Okada S; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Tanaka H; Department of Sports Medical Science, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. tanaka.hiroyuki.med@osaka-u.ac.jp.
Πηγή: Scientific reports [Sci Rep] 2025 Jan 06; Vol. 15 (1), pp. 950. Date of Electronic Publication: 2025 Jan 06.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s): Original Publication: London : Nature Publishing Group, copyright 2011-
Ιατρικοί όροι (MeSH): Nanofibers*/chemistry , Vitamin B 12*/analogs & derivatives , Vitamin B 12*/pharmacology , Neuroprotective Agents*/pharmacology , Intestinal Mucosa*, Sciatic Nerve/physiology ; Axons/physiology ; Tissue Adhesions/prevention & control ; Animals ; Rats ; Swine ; Intestine, Small ; Male ; Rats, Sprague-Dawley
Περίληψη: Postoperative adhesion around nerves sometimes results in sensory and motor dysfunctions. To prevent these disorders, we have developed an electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), an active form of vitamin B12 with anti-inflammatory and neuroregenerative effects. This study aimed to investigate the neuroprotective effects of MeCbl sheets against postoperative adhesion and to compare the effects of MeCbl sheets with those of porcine small intestinal submucosa (SIS) sheets using a rat sciatic nerve adhesion model. Behavioral and electrophysiological analyses showed superior results in the MeCbl sheet group compared with those in the untreated group, all of which were non-inferior to the SIS sheet group. Histological analysis revealed less collagen and inflammatory cell invasion into the nerve parenchyma and a higher number of residual axons and myelination rate in the MeCbl sheet group than in the untreated group. Moreover, the MeCbl sheet group was superior to the SIS sheet group in terms of the myelination rate and decreased number of infiltrating macrophages. Furthermore, the distribution of residual axons by diameter revealed that the MeCbl sheet group had thicker axons than the SIS sheet group. The use of MeCbl sheets may represent a novel approach for preventing secondary nervous system impairment following inflammation.
(© 2024. The Author(s).)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
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Substance Nomenclature: P6YC3EG204 (Vitamin B 12)
0 (Neuroprotective Agents)
BR1SN1JS2W (mecobalamin)
Entry Date(s): Date Created: 20250106 Date Completed: 20250106 Latest Revision: 20250331
Update Code: 20260130
PubMed Central ID: PMC11704040
DOI: 10.1038/s41598-024-78933-y
PMID: 39762256
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2045-2322
DOI:10.1038/s41598-024-78933-y