Academic Journal
Exploration of phytochemical components, bioactivity based fractionation, and in silico HMG-CoA reductase inhibitory effect of Euphorbia dendroides chloroform extract.
| Τίτλος: | Exploration of phytochemical components, bioactivity based fractionation, and in silico HMG-CoA reductase inhibitory effect of Euphorbia dendroides chloroform extract. |
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| Συγγραφείς: | Ali FT; Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt., El-Gneady FF; Department of Medicinal and Aromatic plants, Desert Research Center, Cairo, Egypt., Ahmed FA; Department of Medicinal and Aromatic plants, Desert Research Center, Cairo, Egypt., Abd El-Sattar NEA; Chemistry Department, Faculty of Sciences, Ain shams University, Cairo, Egypt., Mostafa MM; Cardiovascular hospital, Ain Shams University Hospitals, Ain Shams University., El-Adl K; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Elhady MM; Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Jun; Vol. 40 (11), pp. 3039-3047. Date of Electronic Publication: 2025 Jan 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/chemistry , Euphorbia*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry, Simvastatin/pharmacology ; Plant Leaves/chemistry ; Hypercholesterolemia/drug therapy ; Chloroform/chemistry ; Malondialdehyde/metabolism ; Superoxide Dismutase/metabolism ; Glutathione Peroxidase/metabolism ; Animals ; Rats ; Molecular Docking Simulation |
| Περίληψη: | The chloroform extract of leaves of E. dendroides L, reduced the levels of lipid profile in rats with hypercholesterolaemia to near-normal levels. Additionally, it significantly decreased the amount of malondialdehyde (MDA). In addition, the extract augmented the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in the hypercholesterolemic treated rats. The docking results verified the binding mechanism of isolated compound as HMG-CoA reductase inhibitor. The identified compound has the essential pharmacophoric features of Simvastatin. Furthermore, the ADMET profile of an isolated terpene was computed and compared to that of simvastatin as a reference medication. This compound demonstrated a favourable absorption rate of 90.44, which is similar to that of simvastatin (94. 63). Additionally, it demonstrated better CNS penetration and lower excretion rates than simvastatin, resulting in a longer duration of action. It also has an extensive therapeutic window and better selectivity towards cancer cells in opposition to normal cells. |
| Contributed Indexing: | Keywords: Anti-hyperlipidemicagents; Euphorbia dendroides; HMG-CoA reductase; molecular docking |
| Substance Nomenclature: | 0 (Plant Extracts) 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) AGG2FN16EV (Simvastatin) 0 (Phytochemicals) 7V31YC746X (Chloroform) 4Y8F71G49Q (Malondialdehyde) EC 1.15.1.1 (Superoxide Dismutase) EC 1.11.1.9 (Glutathione Peroxidase) |
| Entry Date(s): | Date Created: 20250104 Date Completed: 20260528 Latest Revision: 20260528 |
| Update Code: | 20260528 |
| DOI: | 10.1080/14786419.2024.2448843 |
| PMID: | 39754527 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2024.2448843 |