Academic Journal
Genomic insights on cgMLST markers, drug resistance, and urease cluster of Proteus mirabilis strains.
| Τίτλος: | Genomic insights on cgMLST markers, drug resistance, and urease cluster of Proteus mirabilis strains. |
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| Συγγραφείς: | Lian S; School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing, China., Liu Y; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Hu S; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Shen C; Department of Urology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China., Ma Y; CapitalBio Technology, Beijing, China., Yin P; School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing, China., He Z; School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing, China. |
| Πηγή: | Microbiology spectrum [Microbiol Spectr] 2025 Jan 07; Vol. 13 (1), pp. e0099224. Date of Electronic Publication: 2024 Dec 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : ASM Press, 2013- |
| Ιατρικοί όροι (MeSH): | Proteus mirabilis*/genetics , Proteus mirabilis*/drug effects , Proteus mirabilis*/enzymology , Anti-Bacterial Agents*/pharmacology , Urease*/genetics, Proteus Infections/microbiology ; Genome, Bacterial/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Quinolones/pharmacology ; Carbapenems/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Resistance, Bacterial/genetics ; Humans ; Multilocus Sequence Typing ; Phylogeny ; Genomics ; Microbial Sensitivity Tests ; Multigene Family |
| Περίληψη: | Proteus mirabilis, a significant pathogenic bacterium within the Enterobacteriaceae family, is widely distributed across various natural environments. This study conducted a genomic comparison analysis of 1,267 strains of P. mirabilis using extensive genome data from public databases. The objective was to elucidate the pan-genomic structure of P. mirabilis, revealing the composition and distribution of core and accessory gene families among different strains. Additionally, an attempt was made to construct a core genome multilocus sequence typing scheme specific to this species in order to enhance the precision of describing genetic diversity and evolutionary relationships. Furthermore, the study delved into the mechanisms of resistance of P. mirabilis to carbapenems and quinolones. Our findings underscore significant challenges posed by P. mirabilis in terms of antibiotic resistance, with widespread resistance observed particularly against beta-lactams and an increasing trend in resistance to carbapenems and quinolones. These results highlight the severity of P. mirabilis as a pathogen and underscore its rapid evolution and adaptability in developing resistance. This study aims to deepen our understanding of the antibiotic resistance of P. mirabilis, providing important insights for the development of future antimicrobial drugs, promoting effective treatment and control of this pathogen, and mitigating its threat to human health. Importance: The bacterium Proteus mirabilis is a common pathogenic bacterium that is known to cause a variety of human infections. The drug-resistant genes carried by P. mirabilis present a significant challenge to clinical treatment, particularly in regard to the organism's notable resistance to commonly used beta-lactam and quinolone drugs. Furthermore, the prevalence of the urease gene cluster of P. mirabilis at the urease gene level may be associated with the formation of kidney stones. The objective of the study is to analyze the bacterium's drug resistance, urease gene clusters, and gene distribution in genomes in order to facilitate the development of antimicrobial drugs and improve the treatment and control of P. mirabilis infections. |
| Competing Interests: | The authors declare no conflict of interest. |
| Grant Information: | 2023YFC3603104 MOST | National Key Research and Development Program of China (NKPs) |
| Contributed Indexing: | Keywords: Proteus mirabilis; cgMLST markers; drug-resistance; plasmid genome prediction; urease gene cluster |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) EC 3.5.1.5 (Urease) 0 (Bacterial Proteins) 0 (Quinolones) 0 (Carbapenems) |
| Entry Date(s): | Date Created: 20241206 Date Completed: 20250109 Latest Revision: 20250109 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11705806 |
| DOI: | 10.1128/spectrum.00992-24 |
| PMID: | 39641568 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2165-0497 |
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| DOI: | 10.1128/spectrum.00992-24 |