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Comparative Analysis of Cellulite Treatment Modalities: A Systematic Review.

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Τίτλος: Comparative Analysis of Cellulite Treatment Modalities: A Systematic Review.
Συγγραφείς: Lim SK; The Manchester Centre for Plastic Surgery and Burns, Wythenshawe Hospital, Manchester, UK. Su.Lim@srft.nhs.uk.; Department of Plastic and Reconstructive Surgery, Ulster Hospital, Belfast, Northern Ireland, UK. Su.Lim@srft.nhs.uk., Gultekin G; Queen Mary, University of London, London, UK., Suresan S; Carderdale and Huddersfield Foundation Trust, Huddersfield, UK., Jacob A; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Zou Y; Department of Natural and Applied Sciences, Hope College, Holland, Michigan, USA., Liyanage DD; Queen Elizabeth Hospital, Birmingham, UK., Parekh JN; Department of Plastic and Reconstructive Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Mavilakandy AK; Department of Internal Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Vyas K; Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, US., Khajuria A; Nuffield Department of Surgical Sciences, Kellogg College, University of Oxford, Oxford, UK.
Πηγή: Aesthetic plastic surgery [Aesthetic Plast Surg] 2025 Apr; Vol. 49 (7), pp. 2051-2075. Date of Electronic Publication: 2024 Nov 15.
Τύπος έκδοσης: Journal Article; Systematic Review; Comparative Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 7701756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5241 (Electronic) Linking ISSN: 0364216X NLM ISO Abbreviation: Aesthetic Plast Surg Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, Springer-Verlag.
Ιατρικοί όροι (MeSH): Cellulite*/therapy , Cellulite*/diagnosis, Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Female ; Male ; Esthetics ; Adult
Περίληψη: Background: Cellulite is a highly prevalent and aesthetically distressing skin condition. Whilst there are a variety of treatment modalities, none are definitively established.
Objective: This systematic review aims to assess invasive and noninvasive treatment modalities for cellulite management.
Methods: The review protocol was published and registered a priori (PROSPERO CRD42022359334). A comprehensive electronic search for relevant randomised controlled trials, (RCTs) was performed in CENTRAL, MEDLINE, Embase and Web of Science databases. Study quality and risk of bias were assessed using Cochrane's risk of bias tool, respectively.
Results: Overall, 753 studies were initially identified, of which 24 randomised controlled trials (RCTs) satisfied the eligibility criteria with a total of 2084 patients with a mean follow-up of 3.33 ± 13.4 weeks. Evaluated interventions included mechanical stimulation, topical therapy, shock wave therapy (SWT), laser and light-based devices, radiofrequency therapy, subcutaneous injectables, and ultrasound. SWT emerged as a standout intervention, demonstrating a consistent cellulite reduction score of 2.07 ± 0.39 across four studies. Radiofrequency therapy exhibited a statistically significant reduction of thigh circumference (- 2.09 cm, p < 0.001) and subcutaneous tissue thickness (- 2.23 cm, p < 0.001). Subcutaneous injectables, specifically collagenase Clostridium histolyticum-aaes, demonstrated a statistically significant improvement in the clinician-reported photonumeric cellulite severity scale (17.0%) and patient-reported photonumeric cellulite severity scale (25.7%) (p < 0.001). The overall quality of the studies using the grading of recommendations, assessment, development and evaluation approach was moderate.
Conclusion: This is the first methodologically robust systematic review evaluating interventions for cellulite. SWT, radiofrequency therapy, and subcutaneous injectables have shown promising findings in cellulite treatment.
Level of Evidence I: The journal asks authors to assign a level of evidence to each article. For a complete description of Evidence-Based Medicine ratings, see the Table of Contents or the online Instructions for Authors at www.springer.com/00266 .
(© 2024. Crown.)
Competing Interests: Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Human Participants: This article contains no studies with human participants or animals performed by any of the authors.
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Contributed Indexing: Keywords: Cellulite; Invasive; Lipodermatosclerosis; Noninvasive; Oedematous fibrosclerotic panniculopathy
Entry Date(s): Date Created: 20241115 Date Completed: 20250425 Latest Revision: 20260513
Update Code: 20260513
DOI: 10.1007/s00266-024-04365-8
PMID: 39547984
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1432-5241
DOI:10.1007/s00266-024-04365-8