Local and systemic photobiomodulation using a 650 nm LED on skin temperature and hyperalgesia in cellulite: a randomized, placebo-controlled and double-blinded clinical trial.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Local and systemic photobiomodulation using a 650 nm LED on skin temperature and hyperalgesia in cellulite: a randomized, placebo-controlled and double-blinded clinical trial.
Συγγραφείς:	Lopes-Martins RAB; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil. ralopesmartins@gmail.com.; Programa de Pós-Graduação em Bioengenharia, Universidade Brasil, Av. Carolina Fonseca 236, Itaquera, SP, Brazil. ralopesmartins@gmail.com., Bueno F; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Ferreira HODC; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Faria LA; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Sousa MMB; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Lobo AB; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Freitas VFDS; Laboratory of Health Technologies - LATES, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Lopes-Martins PSL; Laboratory of Biophotonics and Experimental Therapeutics - LABITEX, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil., Aimbire F; Laboratório de Imunofarmacologia, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo- UNIFESP, São José dos Campos, SP, Brazil., Leonardo PS; Laboratory of Health Technologies - LATES, Evangelical University of Goiás (UniEVANGELICA), Av. Universitária Km 3.5, Anápolis, GO, Brazil.
Πηγή:	Lasers in medical science [Lasers Med Sci] 2024 Nov 13; Vol. 39 (1), pp. 275. Date of Electronic Publication: 2024 Nov 13.
Τύπος έκδοσης:	Journal Article; Randomized Controlled Trial
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Springer Country of Publication: England NLM ID: 8611515 Publication Model: Electronic Cited Medium: Internet ISSN: 1435-604X (Electronic) Linking ISSN: 02688921 NLM ISO Abbreviation: Lasers Med Sci Subsets: MEDLINE
Imprint Name(s):	Publication: London : Springer Original Publication: London : Baillière Tindall, c1986-
Ιατρικοί όροι (MeSH):	Low-Level Light Therapy/methods , Skin Temperature/radiation effects , Hyperalgesia/therapy , Hyperalgesia/radiotherapy , Cellulite/radiotherapy , Cellulite/therapy, Humans ; Female ; Adult ; Double-Blind Method ; Middle Aged
Περίληψη:	Cellulite is a skin condition that significantly affects women, characterized by "holes" or depressions in the skin, affecting approximately 95% of women at some point in their lives. Cellulite often presents inflammatory symptoms such as increased skin temperature and hyperalgesia. Photobiomodulation, whether applied locally or systemically, has demonstrated important anti-inflammatory effects in various conditions. This study investigates the effects of local and systemic photobiomodulation on hip culottes temperature increases and hyperalgesia in patients with grades 2 to 4 cellulite. Cellulite assessment was carried out using detailed anamnesis, photographic records, algometry, and infrared thermography. Participants received randomized bilateral treatment with or without systemic irradiation using LED photobiomodulation on the hip culottes for four weeks, three times a week. This study aimed to evaluate the effect of photobiomodulation, especially locally applied, together or not with systemic irradiation, on cellulite hyperalgesia and skin temperature among 25 female participants. The group that received only LED treatment showed an increase in pain threshold of 8% and 20% on the right and left sides, respectively, while the group treated with LED + ILIB showed an increase in pain threshold of 32% on both sides. Local photobiomodulation produced a skin temperature decrease of 0.4 °C, while the combination of local and systemic irradiation produced an average skin temperature decrease of 1.2 °C. Our results clearly demonstrate a significantly beneficial effect of LED therapy for cellulite treatment, especially when administered in combination with mILIB, leading to a significant reduction of pain hypersensitivity and skin temperature, indicating a regional subcutaneous improvement of the inflammatory status. (© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
Competing Interests:	Declarations Competing interests The Authors declare non-financial interests directly or indirectly related to the present work submitted for publication.
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Grant Information:	Conselho Nacional de Desenvolvimento Científico e Tecnológico Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de Goiás Fundação de Amparo à Pesquisa do Estado de Goiás
Contributed Indexing:	Keywords: Cellulite; ILIB; Infrared thermography; LED; Photobiomodulation; RCT
Entry Date(s):	Date Created: 20241113 Date Completed: 20241113 Latest Revision: 20261010
Update Code:	20261010
DOI:	10.1007/s10103-024-04232-7
PMID:	39535674
Βάση Δεδομένων:	MEDLINE

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Περιγραφή
ISSN:	1435-604X
DOI:	10.1007/s10103-024-04232-7