Academic Journal
Hypertonic Saline Nasal Rinse Intervention: Immunomodulatory Effects in Dairy Workers.
| Τίτλος: | Hypertonic Saline Nasal Rinse Intervention: Immunomodulatory Effects in Dairy Workers. |
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| Συγγραφείς: | Erlandson G; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Magzamen S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA., Sharp JL; Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.; Sharp Analytics LLC, Fort Collins, CO, USA., Seidel J; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Poole JA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Bradford M; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Schaeffer JW; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.; Department of Environmental and Occupational Health, Colorado School of Public Health, Denver, CO, USA. |
| Πηγή: | Journal of agromedicine [J Agromedicine] 2025 Jan; Vol. 30 (1), pp. 27-37. Date of Electronic Publication: 2024 Oct 23. |
| Τύπος έκδοσης: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9421530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-0813 (Electronic) Linking ISSN: 1059924X NLM ISO Abbreviation: J Agromedicine Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2009- : Abingdon, Oxford : Taylor & Francis Original Publication: Binghamton, NY : Haworth Medical Press, c1994- |
| Ιατρικοί όροι (MeSH): | Occupational Exposure*/adverse effects , Occupational Exposure*/prevention & control , Occupational Exposure*/analysis , Dairying*, Saline Solution, Hypertonic/pharmacology ; Saline Solution, Hypertonic/administration & dosage ; Particulate Matter/analysis ; Endotoxins/analysis ; Microbiota/drug effects ; Humans ; Female ; Adult ; Male ; Aerosols ; Middle Aged ; Nasal Lavage |
| Περίληψη: | Objective: Increased risk of occupational exposure to bioaerosols has long been recognized in livestock operations including dairy facilities. Spanning the inhalable fraction (0-100 μm), dairy bioaerosols comprise a wide variety of inflammatory components that deposit in the nasopharyngeal region. The resultant inflammatory response from bioaerosol exposure is likely driving the increased prevalence of respiratory disease observed in dairy workers. It is also thought the microbiome of the upper respiratory system may help mediate this inflammation. We investigated the viability of a low-cost hypertonic saline nasal rinse intervention in modulating inflammatory responses in bioaerosol exposed dairy workers and its impact on microbial diversity. Methods: Pre- and post-shift nasal rinses were administered and collected alongside full shift inhalable personal breathing zone (PBZ) samples for each participant for up to 5 consecutive days. Treatment group participants (n = 23) received hypertonic saline rinses while control group participants (n = 22) received normotonic saline rinses. Particulate matter (PM) and endotoxin concentrations were quantified from PBZ samples using gravimetric and enzymatic analytical methods, respectively. Pre- and post-shift rinses were analyzed for pro- and anti-inflammatory markers and microbial diversity using a multiplex assay and 16S rRNA sequencing, respectively. Results: PM and endotoxin concentrations were comparable between groups indicating similar exposures. Post-shift pro-inflammatory markers were significantly higher than pre-shift for IL-13 (p = .047), IL-1β (p < .001), IL-6 (p < .001), IL-8 (p < .001), and TNF-α (p = .024). There was no evidence of a difference in log concentrations between intervention group or day among any of the measured inflammatory markers. Anti-inflammatory IL-10 concentrations increased across the 5 sample days, independent of treatment group suggesting tonicity may not be driving the change. However, this result was not significant (p = .217). Nasal microbiome alpha (within sample) and beta (between sample) diversity metrics did not differ significantly between group or day demonstrating no adverse washout intervention effects. Conclusion: This study provided encouraging results that warrant future research to further evaluate saline nasal rinses as a workplace intervention. |
| References: | Open Access Maced J Med Sci. 2019 Jul 28;7(14):2350-2359. (PMID: 31592062) PLoS One. 2020 Apr 30;15(4):e0232456. (PMID: 32353071) mSystems. 2018 Apr 17;3(3):. (PMID: 29719869) Can Respir J. 2014 Sep-Oct;21(5):277-8. (PMID: 25299221) Am J Rhinol Allergy. 2018 Jul;32(4):269-279. (PMID: 29774747) J Occup Environ Hyg. 2018 Mar;15(3):182-193. (PMID: 29157144) J Fam Pract. 2002 Dec;51(12):1049-55. (PMID: 12540331) J Occup Environ Hyg. 2012;9(7):D136-40. (PMID: 22702233) Am J Ind Med. 1996 Jan;29(1):33-40. (PMID: 8808040) PLoS One. 2017 Aug 29;12(8):e0183898. (PMID: 28850578) J Occup Environ Hyg. 2005 Nov;2(11):577-85. (PMID: 16234218) J Occup Environ Med. 2000 Mar;42(3):260-9. (PMID: 10738705) J Immunol. 2002 Feb 1;168(3):1389-96. (PMID: 11801680) J Agromedicine. 2009;14(1):58-65. (PMID: 19214856) J Allergy Clin Immunol. 2004 Dec;114(6):1369-75. (PMID: 15577837) Environ Res. 2018 Aug;165:286-293. (PMID: 29758401) J Toxicol Environ Health A. 2010;73(1):5-22. (PMID: 19953416) J Occup Environ Hyg. 2023 Jan;20(1):14-22. (PMID: 36260509) Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047) Environ Sci Technol. 2017 Jun 6;51(11):6430-6440. (PMID: 28492313) Science. 2012 Jun 8;336(6086):1262-7. (PMID: 22674330) Curr Allergy Asthma Rep. 2023 Jun;23(6):325-339. (PMID: 37191901) PLoS Biol. 2006 Oct;4(10):e337. (PMID: 17032065) Am J Ind Med. 2017 Mar;60(3):255-263. (PMID: 28195657) mSystems. 2019 Feb 12;4(1):. (PMID: 30801021) PLoS One. 2019 Mar 12;14(3):e0212949. (PMID: 30861031) J Agromedicine. 2015;20(1):31-42. (PMID: 25635741) Chest. 2009 Sep;136(3):716-725. (PMID: 19318669) Biometrics. 2015 Dec;71(4):1042-9. (PMID: 26038228) J Occup Environ Med. 2020 Jun;62(6):424-430. (PMID: 32221115) Crit Care Med. 2012 Sep;40(9):2647-53. (PMID: 22732292) Ann Occup Hyg. 2014 Jul;58(6):707-23. (PMID: 24748620) Rhinology. 1999 Dec;37(4):175-8. (PMID: 10670032) PLoS One. 2017 Dec 18;12(12):e0189536. (PMID: 29253007) J Agromedicine. 2013;18(3):184-6. (PMID: 23844786) J Agromedicine. 2013;18(3):187-97. (PMID: 23844787) Chest. 1994 Nov;106(5):1487-92. (PMID: 7956408) Ann Work Expo Health. 2017 Apr 01;61(3):344-355. (PMID: 28355415) J Exp Med. 1991 Nov 1;174(5):1209-20. (PMID: 1940799) Ann Surg. 2006 Jan;243(1):47-57. (PMID: 16371736) Allergy. 2002 Jun;57(6):480-7. (PMID: 12028112) Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288) J Occup Environ Med. 2013 Jan;55(1):74-9. (PMID: 23235464) |
| Grant Information: | R01 OH012045 United States OH NIOSH CDC HHS; U01 OH010840 United States OH NIOSH CDC HHS |
| Contributed Indexing: | Keywords: Agricultural health; bioaerosols; inflammation; intervention; nasal lavage |
| Substance Nomenclature: | 0 (Saline Solution, Hypertonic) 0 (Particulate Matter) 0 (Aerosols) 0 (Endotoxins) |
| Entry Date(s): | Date Created: 20241023 Date Completed: 20241219 Latest Revision: 20260102 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12165301 |
| DOI: | 10.1080/1059924X.2024.2416425 |
| PMID: | 39440411 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1545-0813 |
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| DOI: | 10.1080/1059924X.2024.2416425 |