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Identification of Candidate Immunodominant Epitopes and Their HLA-Binding Prediction on BK Polyomavirus Proteins in Healthy Donors.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Identification of Candidate Immunodominant Epitopes and Their HLA-Binding Prediction on BK Polyomavirus Proteins in Healthy Donors.
Συγγραφείς: Lara-de-León AG; Advanced & Cell Therapy Services, Banc de Sang i Teixits (Blood and Tissue Bank, BST), Barcelona, Spain., Mora-Buch R; Advanced & Cell Therapy Services, Banc de Sang i Teixits (Blood and Tissue Bank, BST), Barcelona, Spain.; Transfusional Medicine Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain., Cantó E; Advanced & Cell Therapy Services, Banc de Sang i Teixits (Blood and Tissue Bank, BST), Barcelona, Spain.; Transfusional Medicine Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain., Peña-Gómez C; Mental Health and Neurosciences, Mixt Unit, Parc Taulí Research and Innovation Institute (I3PT), Barcelona, Spain., Rudilla F; Transfusional Medicine Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.; Immunogenetics and Histocompatibility Laboratory, Banc de Sang i Teixits (Blood and Tissue Bank, BST), Barcelona, Spain.
Πηγή: HLA [HLA] 2024 Oct; Vol. 104 (4), pp. e15722.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101675570 Publication Model: Print Cited Medium: Internet ISSN: 2059-2310 (Electronic) Linking ISSN: 20592302 NLM ISO Abbreviation: HLA Subsets: MEDLINE
Imprint Name(s): Original Publication: Oxford : Wiley Blackwell, [2016]-
Ιατρικοί όροι (MeSH): BK Virus*/immunology , Immunodominant Epitopes*/immunology, Epitopes, T-Lymphocyte/immunology ; Polyomavirus Infections/immunology ; Polyomavirus Infections/virology ; HLA Antigens/immunology ; Viral Proteins/immunology ; Viral Proteins/chemistry ; Humans ; Protein Binding ; Epitope Mapping ; Healthy Volunteers ; Male ; Female ; Adult ; Alleles
Περίληψη: BK polyomavirus infection is an important cause of graft loss in transplant patients, however, currently available therapies lack effectiveness against this pathogen. Identification of immunological targets for potential treatments is therefore necessary. The aim of this study was to predict candidates of immunodominant epitopes within four BK virus proteins (VP1, VP2, VP3 and LTA) using PBMCs from 44 healthy donors. We used the ELISpot epitope mapping method to evaluate the T-cell response, and HLA-peptide binding was predicted using the NetMHCpan algorithm. A total of 11 potential peptides were selected for VP1, 3 for VP2/VP3 and 13 for LTA. Greater reactivity was observed for VP1 and LTA proteins compared with VP2/VP3. Most of the peptides selected as potential immunodominant candidates were restricted towards several HLA class I and II alleles, with predominant HLA class I binding by computational predictions. Based on these findings, the sequences of the selected immunodominant epitopes candidates and their corresponding HLA restrictions could contribute to the optimisation of functional assays and aid in the design and improvement of immunotherapy strategies against BK virus infections.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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Contributed Indexing: Keywords: BK virus; ELISpot; HLA; HLA‐binding; LTA; T‐cell epitope; VP1; VP2/VP3
Substance Nomenclature: 0 (Immunodominant Epitopes)
0 (Epitopes, T-Lymphocyte)
0 (HLA Antigens)
0 (Viral Proteins)
Entry Date(s): Date Created: 20241022 Date Completed: 20241022 Latest Revision: 20241025
Update Code: 20260130
DOI: 10.1111/tan.15722
PMID: 39435889
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2059-2310
DOI:10.1111/tan.15722