Relevance, strategies, and added value of mouse models in androgenetics.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Relevance, strategies, and added value of mouse models in androgenetics.
Συγγραφείς:	Singh V; Department of Biomedical Sciences, Cornell College of Veterinary Medicine, Ithaca, New York, USA., Schimenti JC; Department of Biomedical Sciences, Cornell College of Veterinary Medicine, Ithaca, New York, USA.; Department of Molecular Biology & Genetics, Cornell University, Ithaca, New York, USA.
Πηγή:	Andrology [Andrology] 2025 Jul; Vol. 13 (5), pp. 1158-1169. Date of Electronic Publication: 2024 Sep 19.
Τύπος έκδοσης:	Journal Article; Review; Research Support, N.I.H., Extramural
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2927 (Electronic) Linking ISSN: 20472919 NLM ISO Abbreviation: Andrology Subsets: MEDLINE
Imprint Name(s):	Original Publication: Oxford : Wiley-Blackwell, 2013-
Ιατρικοί όροι (MeSH):	Infertility, Male/genetics , Fertility/genetics , Disease Models, Animal*, Animals ; Mice ; Male ; Humans ; Female ; Mice, Knockout ; Models, Animal
Περίληψη:	Background: Male Infertility is a prevalent condition worldwide, and a substantial fraction of cases are thought to have a genetic basis. Investigations into the responsible genes is limited experimentally, so mice have been used extensively to identify genes required for fertility and to understand their functions. Objectives: To review the progress made in reproductive genetics based on experiments in mice, the impact upon clinical fertility genetics, and discuss how evolving technologies will continue to advance our understanding of human infertility genes. Results and Discussion: Gene knockout studies in mice have shown that several hundreds of genes are required for normal fertility and that this number is much higher in males than in females. In addition to gene discovery, the mouse is a powerful platform for functionally dissecting genetic pathways, modeling putative human infertility variants, identifying contraceptive targets, and developing in vitro gametogenesis. Conclusion: These ongoing studies in mice have made an enormous contribution to our understanding of the genetics of human reproduction in the sense that the "parts list" of genes for mammalian gametogenesis is being elucidated. This would have been impossible to do in humans, and in vitro systems are not yet adequate to associate genes with andrological phenotypes, especially in the germline. (© 2024 American Society of Andrology and European Academy of Andrology.)
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Grant Information:	R01 HD082568 United States HD NICHD NIH HHS; R01 HD082568 United States NH NIH HHS
Contributed Indexing:	Keywords: gene editing; in vitro gametogenesis; infertility; mouse
Entry Date(s):	Date Created: 20240920 Date Completed: 20250624 Latest Revision: 20260619
Update Code:	20260620
DOI:	10.1111/andr.13761
PMID:	39300831
Βάση Δεδομένων:	MEDLINE

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ISSN:	2047-2927
DOI:	10.1111/andr.13761