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A Urease-Based pH Photoswitch: A General Route to Light-to-pH Transduction.

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Τίτλος: A Urease-Based pH Photoswitch: A General Route to Light-to-pH Transduction.
Συγγραφείς: Ivanov NM; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525AJ, Nijmegen, The Netherlands., Slivkov AI; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525AJ, Nijmegen, The Netherlands., Huck WTS; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525AJ, Nijmegen, The Netherlands.
Πηγή: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Jan 15; Vol. 64 (3), pp. e202415614. Date of Electronic Publication: 2024 Nov 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
Imprint Name(s): Publication: <2004-> : Weinheim : Wiley-VCH
Original Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-
Ιατρικοί όροι (MeSH): Urease*/metabolism , Urease*/antagonists & inhibitors , Urease*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Light*, Urea/metabolism ; Urea/chemistry ; Hydrogen-Ion Concentration ; Photochemical Processes
Περίληψη: New approaches for the integration of chemical and physical stimuli to control the dynamics of artificial enzymatic reaction networks (ERNs) are needed. Here, we present a general approach to convert a light stimulus into a time-programmed pH response. We developed and characterized a panel of photoswitchable inhibitors of urease. Urease activity, now regulated by light via the photoinhibitors, leads to an increase in pH upon hydrolysis of urea into ammonia. Careful choice of characteristics of light, and concentrations of enzyme, substrate, and photoinhibitor, allowed us to control the timing of the pH transition. Furthermore, as all enzymes have an activity-pH profile, the urease photoinhibitor system can be used to regulate the activities of other enzymes in small reaction networks.
(© 2024 The Author(s). Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
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Grant Information: Gravity program 024.001.035 Ministerie van Onderwijs, Cultuur en Wetenschap; ERC Adv. Grant Life Inspired, grant agreement No. 833466 International ERC_ European Research Council
Contributed Indexing: Keywords: enzymatic activity photoregulation; light-responsive materials; pH feedback; photoswitches; urease autocatalysis
Substance Nomenclature: EC 3.5.1.5 (Urease)
8W8T17847W (Urea)
0 (Enzyme Inhibitors)
Entry Date(s): Date Created: 20240912 Date Completed: 20250424 Latest Revision: 20250515
Update Code: 20260130
PubMed Central ID: PMC11735890
DOI: 10.1002/anie.202415614
PMID: 39263723
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1521-3773
DOI:10.1002/anie.202415614