Academic Journal
Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development.
| Title: | Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development. |
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| Authors: | Natsuaki Y; Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA., Leynes A; iSono Health Inc., South San Francisco, California, USA., Wangerin K; GE Healthcare, Waukesha, Wisconsin, USA., Hamdi M; Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA., Rajagopal A; University of California, San Francisco, San Francisco, California, USA., Kinahan PE; University of Washington, Seattle, Washington, USA., Laforest R; Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA., Larson PEZ; University of California, San Francisco, San Francisco, California, USA., Hope TA; University of California, San Francisco, San Francisco, California, USA., James SS; University of Utah, Salt Lake City, Utah, USA. |
| Source: | Journal of applied clinical medical physics [J Appl Clin Med Phys] 2024 Nov; Vol. 25 (11), pp. e14507. Date of Electronic Publication: 2024 Sep 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley on behalf of American Association of Physicists in Medicine Country of Publication: United States NLM ID: 101089176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-9914 (Electronic) Linking ISSN: 15269914 NLM ISO Abbreviation: J Appl Clin Med Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : Malden, MA : Wiley on behalf of American Association of Physicists in Medicine Original Publication: Reston, VA : American College of Medical Physics, c2000- |
| MeSH Terms: | Image Processing, Computer-Assisted*/methods , Magnetic Resonance Imaging*/methods , Positron Emission Tomography Computed Tomography*/methods, Multimodal Imaging/methods ; Positron-Emission Tomography/methods ; Pelvic Neoplasms/diagnostic imaging ; Radiotherapy Planning, Computer-Assisted/methods ; Pelvis/diagnostic imaging ; Humans ; Male ; Algorithms ; Female ; Software ; Radiopharmaceuticals ; Phantoms, Imaging ; Fluorodeoxyglucose F18 |
| Abstract: | Background: In modern positron emission tomography (PET) with multi-modality imaging (e.g., PET/CT and PET/MR), the attenuation correction (AC) is the single largest correction factor for image reconstruction. One way to assess AC methods and other reconstruction parameters is to utilize software-based simulation tools, such as a lesion insertion tool. Extensive validation of these simulation tools is required to ensure results of the study are clinically meaningful. Purpose: To evaluate different PET AC methods using a synthetic lesion insertion tool that simulates lesions in a patient cohort that has both PET/MR and PET/CT images. To further demonstrate how lesion insertion tool may be used to extend knowledge of PET reconstruction parameters, including but not limited to AC. Methods: Lesion quantitation is compared using conventional Dixon-based MR-based AC (MRAC) to that of using CT-based AC (CTAC, a "ground truth"). First, the pre-existing lesions were simulated in a similar environment; a total of 71 lesions were identified in 18 pelvic PET/MR patient images acquired with a time-of-flight simultaneous PET/MR scanner, and matched lesions were inserted contralaterally on the same axial slice. Second, synthetic lesions were inserted into four anatomic target locations in a cohort of four patients who didn't have any observed clinical lesions in the pelvis. Results: The matched lesion insertions resulted in unity between the lesion error ratios (mean SUVs), demonstrating that the inserted lesions successfully simulated the original lesions. In the second study, the inserted lesions had distinct characteristics by target locations and demonstrated negative max-SUV%diff trends for bone-dominant sites across the patient cohort. Conclusions: The current work demonstrates that the applied lesion insertion tool can simulate uptake in pelvic lesions and their expected SUV values, and that the lesion insertion tool can be extended to evaluate further PET reconstruction corrections and algorithms and their impact on quantitation accuracy and precision. (© 2024 The Author(s). Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.) |
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| Grant Information: | R01 AR074492 United States AR NIAMS NIH HHS; 212148 United States GF NIH HHS |
| Contributed Indexing: | Keywords: PET reconstruction; PET/CT; PET/MR; attenuation correction; lesion insertion tool |
| Substance Nomenclature: | 0 (Radiopharmaceuticals) 0Z5B2CJX4D (Fluorodeoxyglucose F18) |
| Entry Date(s): | Date Created: 20240904 Date Completed: 20241106 Latest Revision: 20260305 |
| Update Code: | 20260305 |
| PubMed Central ID: | PMC11539964 |
| DOI: | 10.1002/acm2.14507 |
| PMID: | 39231184 |
| Database: | MEDLINE |
| ISSN: | 1526-9914 |
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| DOI: | 10.1002/acm2.14507 |