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DNA damage in workers exposed to mineral oils.

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Title: DNA damage in workers exposed to mineral oils.
Authors: Zendehdel R; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran., Asgari-Gandomani E; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran., Rafieepour A; Air Pollution Research Center, Occupational Health Research Center, School of Public Health, Iran University of Medical Sciences, Tehran, Iran., Panjali Z; Department of Occupational Health and Safety, Faculty of Health Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Moradpour Z; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran.
Source: Drug and chemical toxicology [Drug Chem Toxicol] 2025 May; Vol. 48 (3), pp. 540-546. Date of Electronic Publication: 2024 Aug 19.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE
Imprint Name(s): Publication: [Philadelphia, PA] : Taylor & Francis Group
Original Publication: New York, Dekker.
MeSH Terms: DNA Damage*/drug effects , Occupational Exposure*/adverse effects , Mineral Oil*/toxicity, Humans ; Male ; Comet Assay ; Adult ; Middle Aged ; Female ; Time Factors ; Case-Control Studies
Abstract: Mineral oils, untreated or mildly treated, have been classified in group 1 as a potential source of cancer by the International Agency for Research on Cancer (IARC). Although numerous studies have implicated metalworking fluids (MWFs) as human carcinogens, toxicology data regarding the mechanism of carcinogenicity are limited. This study is intended to examine the systemic effects of machining workers' exposure to MWFs. The potential toxicity of mineral oils was investigated in 65 lathe workers compared to controls (66 men). The occupational exposure was measured by the National Institute for Occupational Safety and Health (NIOSH) 5026. The DNA damage has been examined by the comet assay method. According to the field assessments, the time-weighted average (TWA) exposure to mineral oil mist was 7.67 ± 3.21 mg/m3. A comet assay of peripheral blood cells showed that tail length (TL) and olive moment (OM) were significantly higher in the exposed group (p < 0.05). A multiple logistic regression analysis revealed that, within subjects with over 10 years of exposure, the odds ratio of worker with high TL, percent of DNA in tail, OM, and tail moment (TM) were 1.68, 1.41, 1.71, and 2.71, respectively. DNA strand break in exposed workers was associated with higher exposure time in years. Mineral oil toxicity could be altered in the presence of by-products and impurities. For a better understanding of genotoxicity, further studies are required.
Contributed Indexing: Keywords: DNA damage; Metalworking fluid; carcinogenicity; mineral oil; occupational exposure
Substance Nomenclature: 8020-83-5 (Mineral Oil)
Entry Date(s): Date Created: 20240819 Date Completed: 20250526 Latest Revision: 20250526
Update Code: 20260130
DOI: 10.1080/01480545.2024.2387803
PMID: 39155643
Database: MEDLINE
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  Data: DNA damage in workers exposed to mineral oils.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zendehdel+R%22&quot;&gt;Zendehdel R&lt;/searchLink&gt;; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Asgari-Gandomani+E%22&quot;&gt;Asgari-Gandomani E&lt;/searchLink&gt;; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Rafieepour+A%22&quot;&gt;Rafieepour A&lt;/searchLink&gt;; Air Pollution Research Center, Occupational Health Research Center, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Panjali+Z%22&quot;&gt;Panjali Z&lt;/searchLink&gt;; Department of Occupational Health and Safety, Faculty of Health Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Moradpour+Z%22&quot;&gt;Moradpour Z&lt;/searchLink&gt;; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%227801723%22&quot;&gt;Drug and chemical toxicology&lt;/searchLink&gt; [Drug Chem Toxicol] 2025 May; Vol. 48 (3), pp. 540-546. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2024 Aug 19.
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  Data: &lt;i&gt;Publication&lt;/i&gt;: [Philadelphia, PA] : Taylor &amp; Francis Group&lt;br /&gt;&lt;i&gt;Original Publication&lt;/i&gt;: New York, Dekker.
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22DNA+Damage%22&quot;&gt;DNA Damage*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22DNA+Damage+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Occupational+Exposure%22&quot;&gt;Occupational Exposure*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Occupational+Exposure+adverse+effects%22&quot;&gt;adverse effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Mineral+Oil%22&quot;&gt;Mineral Oil*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Mineral+Oil+toxicity%22&quot;&gt;toxicity&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Comet+Assay%22&quot;&gt;Comet Assay&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Adult%22&quot;&gt;Adult&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Middle+Aged%22&quot;&gt;Middle Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Time+Factors%22&quot;&gt;Time Factors&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Case-Control+Studies%22&quot;&gt;Case-Control Studies&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Mineral oils, untreated or mildly treated, have been classified in group 1 as a potential source of cancer by the International Agency for Research on Cancer (IARC). Although numerous studies have implicated metalworking fluids (MWFs) as human carcinogens, toxicology data regarding the mechanism of carcinogenicity are limited. This study is intended to examine the systemic effects of machining workers&#39; exposure to MWFs. The potential toxicity of mineral oils was investigated in 65 lathe workers compared to controls (66 men). The occupational exposure was measured by the National Institute for Occupational Safety and Health (NIOSH) 5026. The DNA damage has been examined by the comet assay method. According to the field assessments, the time-weighted average (TWA) exposure to mineral oil mist was 7.67&#160;&#177;&#160;3.21 mg/m&lt;superscript&gt;3&lt;/superscript&gt;. A comet assay of peripheral blood cells showed that tail length (TL) and olive moment (OM) were significantly higher in the exposed group (p&#160;&amp;lt;&#160;0.05). A multiple logistic regression analysis revealed that, within subjects with over 10 years of exposure, the odds ratio of worker with high TL, percent of DNA in tail, OM, and tail moment (TM) were 1.68, 1.41, 1.71, and 2.71, respectively. DNA strand break in exposed workers was associated with higher exposure time in years. Mineral oil toxicity could be altered in the presence of by-products and impurities. For a better understanding of genotoxicity, further studies are required.
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;DNA damage; Metalworking fluid; carcinogenicity; mineral oil; occupational exposure
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  Data: 8020-83-5 (Mineral Oil)
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20240819 &lt;i&gt;Date Completed: &lt;/i&gt;20250526 &lt;i&gt;Latest Revision: &lt;/i&gt;20250526
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  Data: 10.1080/01480545.2024.2387803
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  Data: 39155643
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RecordInfo BibRecord:
  BibEntity:
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      – Type: doi
        Value: 10.1080/01480545.2024.2387803
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 540
    Subjects:
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Comet Assay
        Type: general
      – SubjectFull: Adult
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      – SubjectFull: Middle Aged
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      – SubjectFull: Case-Control Studies
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      – SubjectFull: DNA Damage drug effects
        Type: general
      – SubjectFull: Occupational Exposure adverse effects
        Type: general
      – SubjectFull: Mineral Oil toxicity
        Type: general
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      – TitleFull: DNA damage in workers exposed to mineral oils.
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            – D: 01
              M: 05
              Text: 2025 May
              Type: published
              Y: 2025
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              Value: 48
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