Academic Journal
DNA damage in workers exposed to mineral oils.
| Τίτλος: | DNA damage in workers exposed to mineral oils. |
|---|---|
| Συγγραφείς: | Zendehdel R; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran., Asgari-Gandomani E; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran., Rafieepour A; Air Pollution Research Center, Occupational Health Research Center, School of Public Health, Iran University of Medical Sciences, Tehran, Iran., Panjali Z; Department of Occupational Health and Safety, Faculty of Health Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Moradpour Z; Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran. |
| Πηγή: | Drug and chemical toxicology [Drug Chem Toxicol] 2025 May; Vol. 48 (3), pp. 540-546. Date of Electronic Publication: 2024 Aug 19. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE |
| Imprint Name(s): | Publication: [Philadelphia, PA] : Taylor & Francis Group Original Publication: New York, Dekker. |
| Ιατρικοί όροι (MeSH): | DNA Damage*/drug effects , Occupational Exposure*/adverse effects , Mineral Oil*/toxicity, Humans ; Male ; Comet Assay ; Adult ; Middle Aged ; Female ; Time Factors ; Case-Control Studies |
| Περίληψη: | Mineral oils, untreated or mildly treated, have been classified in group 1 as a potential source of cancer by the International Agency for Research on Cancer (IARC). Although numerous studies have implicated metalworking fluids (MWFs) as human carcinogens, toxicology data regarding the mechanism of carcinogenicity are limited. This study is intended to examine the systemic effects of machining workers' exposure to MWFs. The potential toxicity of mineral oils was investigated in 65 lathe workers compared to controls (66 men). The occupational exposure was measured by the National Institute for Occupational Safety and Health (NIOSH) 5026. The DNA damage has been examined by the comet assay method. According to the field assessments, the time-weighted average (TWA) exposure to mineral oil mist was 7.67 ± 3.21 mg/m3. A comet assay of peripheral blood cells showed that tail length (TL) and olive moment (OM) were significantly higher in the exposed group (p < 0.05). A multiple logistic regression analysis revealed that, within subjects with over 10 years of exposure, the odds ratio of worker with high TL, percent of DNA in tail, OM, and tail moment (TM) were 1.68, 1.41, 1.71, and 2.71, respectively. DNA strand break in exposed workers was associated with higher exposure time in years. Mineral oil toxicity could be altered in the presence of by-products and impurities. For a better understanding of genotoxicity, further studies are required. |
| Contributed Indexing: | Keywords: DNA damage; Metalworking fluid; carcinogenicity; mineral oil; occupational exposure |
| Substance Nomenclature: | 8020-83-5 (Mineral Oil) |
| Entry Date(s): | Date Created: 20240819 Date Completed: 20250526 Latest Revision: 20250526 |
| Update Code: | 20260130 |
| DOI: | 10.1080/01480545.2024.2387803 |
| PMID: | 39155643 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1525-6014 |
|---|---|
| DOI: | 10.1080/01480545.2024.2387803 |