Validity of rapid urease test using swab of gastric mucus to mucosal forceps and 13 C-urease breath test: a multicenter prospective observational study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Validity of rapid urease test using swab of gastric mucus to mucosal forceps and 13 C-urease breath test: a multicenter prospective observational study.
Συγγραφείς:	Yoshikawa T; Department of Gastroenterology and Hepatology, Medical Research Institute Kitano Hospital, PIIF Tazuke Kofukai, 2-4-20, Ohgimachi, Kita-ku, Osaka, 530-8480, Japan. tk_yoshi@kuhp.kyoto-u.ac.jp., Yamauchi A; Department of Gastroenterology and Hepatology, Medical Research Institute Kitano Hospital, PIIF Tazuke Kofukai, 2-4-20, Ohgimachi, Kita-ku, Osaka, 530-8480, Japan., Kou T; Department of Gastroenterology and Hepatology, Medical Research Institute Kitano Hospital, PIIF Tazuke Kofukai, 2-4-20, Ohgimachi, Kita-ku, Osaka, 530-8480, Japan., Murao T; Department of Gastroenterology and Hepatology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Okayama, Japan.; Department of Health Care Medicine, Kawasaki Medical School General Medical Center, 2-6-1, Nakasange, Kita-Ku, Okayama, 700-8505, Japan., Kamada T; Department of Health Care Medicine, Kawasaki Medical School General Medical Center, 2-6-1, Nakasange, Kita-Ku, Okayama, 700-8505, Japan., Suehiro M; Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, 2-6-1, Nakasange, Kita-Ku, Okayama, 700-8505, Japan., Kawano K; Department of Gastroenterology and Hepatology, Hyogo Prefectural Awaji Medical Center, 1-1-137, Shioya, Sumoto City, 656-0021, Hyogo, Japan., Haruma K; Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, 2-6-1, Nakasange, Kita-Ku, Okayama, 700-8505, Japan., Yazumi S; Department of Gastroenterology and Hepatology, Medical Research Institute Kitano Hospital, PIIF Tazuke Kofukai, 2-4-20, Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Πηγή:	BMC gastroenterology [BMC Gastroenterol] 2024 Aug 09; Vol. 24 (1), pp. 258. Date of Electronic Publication: 2024 Aug 09.
Τύπος έκδοσης:	Journal Article; Observational Study; Multicenter Study; Validation Study
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
Imprint Name(s):	Original Publication: London : BioMed Central, [2001-
Ιατρικοί όροι (MeSH):	Breath Tests/methods , Breath Tests/instrumentation , Helicobacter Infections/diagnosis , Helicobacter Infections/microbiology , Urease/analysis , Urease/metabolism , Helicobacter pylori/isolation & purification , Helicobacter pylori/enzymology , Sensitivity and Specificity*, Gastric Mucosa/microbiology ; Surgical Instruments/microbiology ; Humans ; Middle Aged ; Prospective Studies ; Male ; Female ; Aged ; Adult ; Aged, 80 and over ; Endoscopy, Digestive System ; Reproducibility of Results ; Carbon Isotopes
Περίληψη:	Background: Theoretically, a rapid urease test (RUT) using a swab of the gastric wall (Swab-RUT) for Helicobacter pylori (H. pylori) is safe. However, the validity and utility of Swab-RUT remain unclear. Therefore, we assessed the validity and utility of Swab-RUT compared to RUT using mucosal forceps of the gastric wall (Forceps-RUT) and ¹³C-urea breath test (UBT). Methods: This study was a multicenter prospective observational study. When the examinees were suspected of H. pylori infection during esophagogastroduodenoscopy, we performed Swab-RUT and Forceps-RUT continuously. When the examinees were not suspected of H. pylori infection, we performed Swab-RUT alone. We validated the status of H. pylori infection using UBT. Results: Ninety-four examinees were enrolled from four institutions between May 2016 and December 2020 (median age [range], 56.5 [26-88] years). In this study, the sensitivity, specificity, and accuracy of Swab-RUT to UBT were 0.933 (95% confidence interval: 0.779-0.992), 0.922 (0.827-0.974), and 0.926 (0.853-0.970), respectively. The Kappa coefficient of Swab-RUT to UBT was 0.833, and that of Swab-RUT to forceps-RUT was 0.936. No complications were observed in this study. Conclusions: Swab-RUT is a valid examination for the status of H. pylori infection compared to the conventional Forceps-RUT. (© 2024. The Author(s).)
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Contributed Indexing:	Keywords: Helicobacter pylori; 13 C-urea breath test; Atrophic gastritis; Rapid urease test
Substance Nomenclature:	EC 3.5.1.5 (Urease) 0 (Carbon Isotopes)
Entry Date(s):	Date Created: 20240809 Date Completed: 20240810 Latest Revision: 20250203
Update Code:	20260130
PubMed Central ID:	PMC11316279
DOI:	10.1186/s12876-024-03344-2
PMID:	39123129
Βάση Δεδομένων:	MEDLINE

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ISSN:	1471-230X
DOI:	10.1186/s12876-024-03344-2