Academic Journal
A cutting-edge electrochemical sensing platform for the simultaneous determination of the residues of antimicrobial drugs, rifampicin and norfloxacin, in water samples.
| Τίτλος: | A cutting-edge electrochemical sensing platform for the simultaneous determination of the residues of antimicrobial drugs, rifampicin and norfloxacin, in water samples. |
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| Συγγραφείς: | Adane WD; Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia., Chandravanshi BS; Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia. Electronic address: bscv2006@yahoo.com., Getachew N; Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia., Tessema M; Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia. Electronic address: tessemamerid@yahoo.com. |
| Πηγή: | Analytica chimica acta [Anal Chim Acta] 2024 Jul 11; Vol. 1312, pp. 342746. Date of Electronic Publication: 2024 May 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: Amsterdam. |
| Ιατρικοί όροι (MeSH): | Norfloxacin*/analysis , Water Pollutants, Chemical*/analysis , Rifampin*/analysis , Electrochemical Techniques*, Anti-Bacterial Agents/analysis ; Nanotubes, Carbon/chemistry ; Electrodes ; Limit of Detection |
| Περίληψη: | Background: The widespread use and abuse of antibiotics has resulted in the pollution of water sources with antibiotic residues, posing a threat to human health, the environment, and the economy. Therefore, a highly sensitive and selective method is required for their detection in water samples. Herein, advanced ultrasensitive electrochemical sensor platform was developed by integrating gold-silver alloy nanocoral clusters (Au-Ag-ANCCs) with functionalized multi-walled carbon nanotube-carbon paste electrode (f-MWCNT-CPE) and choline chloride (ChCl) nanocomposites for simultaneously determining the residues of antimicrobial drugs, rifampicin (RAMP) and norfloxacin (NFX), in water samples. Results: The developed sensor (Au-Ag-ANCCs/f-MWCNTs-CPE/ChCl) was extensively characterized using several analytical (UV-Vis, FT-IR, XRD, SEM, and EDX) and electrochemical (EIS, CV, and SWV) techniques. It exhibited outstanding performance in a wide linear range, from 14 pM to 115 μM for RAMP, and from 0.9 nM to 200 μM for NFX, with a limit of detection (LOD, 3σ/m, S/N = 3, n = 5) and a limit of quantification (LOQ, 10σ/m, S/N = 3, n = 5) values of 2.7 pM and 8.85 pM for RAMP, and 0.14 nM and 0.47 nM for NFX, respectively. The sensor also exhibited exceptional reproducibility, stability, and resistance to interference. Significance: The developed sensor was effectively utilized to determine RAMP and NFX residues in hospital wastewater, river, and tap water samples, yielding recoveries within the range of 96.8-103 % and relative standard deviations below 5 %. Generally, the proposed sensor demonstrated remarkable performance in detecting the target analytes, making it an ideal tool and the first of its kind for addressing global antibiotic residue pollutants in water sources. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antibiotic residues; Choline chloride; Electrochemical sensor; Gold-silver alloy nanocorals clusters; Norfloxacin; Rifampicin |
| Substance Nomenclature: | N0F8P22L1P (Norfloxacin) 0 (Water Pollutants, Chemical) VJT6J7R4TR (Rifampin) 0 (Anti-Bacterial Agents) 0 (Nanotubes, Carbon) |
| Entry Date(s): | Date Created: 20240604 Date Completed: 20240604 Latest Revision: 20240604 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.aca.2024.342746 |
| PMID: | 38834274 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-4324 |
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| DOI: | 10.1016/j.aca.2024.342746 |