Academic Journal
Eosinophilic Granulomatosis With Polyangiitis: A Case Report.
| Τίτλος: | Eosinophilic Granulomatosis With Polyangiitis: A Case Report. |
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| Συγγραφείς: | Robinson C; Internal Medicine, Henry Ford Health System, Jackson, USA., Minhas JS; Medicine, St. George's University School of Medicine, St. George's, GRD., Kisule A; Rheumatology, Henry Ford Health System, Jackson, USA., Zebda H; Rheumatology, Henry Ford Health System, Detroit, USA. |
| Πηγή: | Cureus [Cureus] 2024 Apr 13; Vol. 16 (4), pp. e58211. Date of Electronic Publication: 2024 Apr 13 (Print Publication: 2024). |
| Τύπος έκδοσης: | Case Reports; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Palo Alto, CA : Cureus, Inc. |
| Περίληψη: | Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of necrotizing small-to-medium vessel vasculitis that can be associated with antineutrophil cytoplasmic antibody (ANCA) positivity, asthma, and eosinophilia. We present the case of a 65-year-old male with a past medical history of asthma who presented to the emergency department with bilateral upper and lower extremity paresthesias, as well as right foot drop, persisting for a two-week duration. His lab work revealed leukocytosis of 20.6 K/uL with 12.36 K/uL of absolute eosinophils as well as elevated inflammatory markers with an erythrocyte sedimentation rate of 32 mm/hr and CRP of 7.3 mg/dL. Both c-ANCA and p-ANCA titers were also elevated at 1:320. An eventual MRI of the entire spine did not reveal any neurologic or anatomic lesions to explain the patient's symptoms. CT imaging was also remarkable for airspace opacities involving the anterior right and bilateral lower posterior lung regions, as well as pansinusitis. A nerve biopsy showed axonopathy as well as evidence of healed vasculitis. Pulse dose steroids were started, which conferred benefits to the patient after other forms of treatment were unsuccessful. Given the rarity of EGPA, we think it is important to add new cases to the literature with a thorough discussion of the steps leading up to how the diagnosis was made. (Copyright © 2024, Robinson et al.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
| References: | Front Med (Lausanne). 2021 Feb 24;8:627776. (PMID: 33718405) Front Immunol. 2014 Nov 03;5:549. (PMID: 25404930) Front Med (Lausanne). 2023 May 03;10:1145257. (PMID: 37215720) Nat Rev Rheumatol. 2023 Jun;19(6):378-393. (PMID: 37161084) Postgrad Med. 2023 Jan;135(sup1):52-60. (PMID: 36259957) |
| Contributed Indexing: | Keywords: churg strauss; churg-strauss syndrome (css); egpa; eosinophilia; eosinophilic granulomatosis with polyangiitis (egpa) |
| Entry Date(s): | Date Created: 20240514 Latest Revision: 20240515 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11089492 |
| DOI: | 10.7759/cureus.58211 |
| PMID: | 38741799 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2168-8184 |
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| DOI: | 10.7759/cureus.58211 |