Academic Journal
Comparative diagnostic performance of rapid urease test with the sweeping method versus tissue sampling method after Helicobacter pylori eradication (with video).
| Title: | Comparative diagnostic performance of rapid urease test with the sweeping method versus tissue sampling method after Helicobacter pylori eradication (with video). |
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| Authors: | Noh CK; Current affiliations: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: cknoh23@gmail.com., Lee GH; Current affiliations: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea., Lee E; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, Houston, Texas, USA., Park B; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea., Lim SG; Current affiliations: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea., Shin SJ; Current affiliations: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea., Lee KM; Current affiliations: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: lkm5104@ajou.ac.kr. |
| Source: | Gastrointestinal endoscopy [Gastrointest Endosc] 2024 Oct; Vol. 100 (4), pp. 660-669.e3. Date of Electronic Publication: 2024 Apr 29. |
| Publication Type: | Journal Article; Comparative Study; Video-Audio Media; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Mosby Yearbook Country of Publication: United States NLM ID: 0010505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6779 (Electronic) Linking ISSN: 00165107 NLM ISO Abbreviation: Gastrointest Endosc Subsets: MEDLINE |
| Imprint Name(s): | Publication: St Louis, Mo : Mosby Yearbook Original Publication: Denver. |
| MeSH Terms: | Helicobacter Infections*/diagnosis , Helicobacter Infections*/drug therapy , Helicobacter pylori*/isolation & purification , Urease*/analysis , Breath Tests*/methods , Sensitivity and Specificity*, Anti-Bacterial Agents/therapeutic use ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Humans ; Male ; Female ; Middle Aged ; Adult ; ROC Curve ; Aged ; Logistic Models ; Polymerase Chain Reaction ; Biopsy |
| Abstract: | Background and Aims: The rapid urease test (RUT) is widely used to detect Helicobacter pylori infection; however, it is not preferred as a monitoring strategy after eradication owing to its low sensitivity. In this study, we evaluated the diagnostic performance of RUT using the sweeping method, which overcomes the limitations of conventional tissue sampling methods after eradication. Methods: Patients who received H pylori eradication treatment were enrolled. Each of the sweeping and conventional methods was performed on the same patients to compare diagnostic performance. Urea breath test (UBT), histology, and polymerase chain reaction were performed to determine true infection. Logistic regression analysis was conducted to investigate reasons for discrepancies between the results of the 2 methods. Results: In 216 patients, the eradication success rate was 68.1%, and the sensitivity and specificity of the sweeping method were 0.812 and 0.912, respectively, whereas those of the conventional method were 0.391 and 0.993, respectively (P < .05 for all). The area under the receiver operating characteristic curve for the sweeping method was higher than that for the conventional method (0.862 vs 0.692, P < .001). The mean time to H pylori detection for the sweeping method was 4.7 ± 4.4 minutes and 12.3 ± 16.1 minutes for the conventional method (P < .001). The risk for inconsistent results between the 2 methods was the highest for UBT values of 1.4‰ to 2.4‰ (odds ratio, 3.8; P = .016). Conclusions: The RUT with the sweeping method could potentially replace the tissue sampling method as a test to confirm H pylori eradication and be an alternative option to UBT for patients requiring endoscopy. (Copyright © 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Disclosure All authors disclosed no financial relationships. This work was partly supported by the Korean College of Helicobacter and Upper Gastrointestinal Research Foundation Grant (no. KCHUGR-202101002). |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20240501 Date Completed: 20241018 Latest Revision: 20260415 |
| Update Code: | 20260416 |
| DOI: | 10.1016/j.gie.2024.04.2901 |
| PMID: | 38692519 |
| Database: | MEDLINE |
| ISSN: | 1097-6779 |
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| DOI: | 10.1016/j.gie.2024.04.2901 |