Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Copper Deficiency Associated with Glycemic Control in Individuals with Type 2 Diabetes Mellitus.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Copper Deficiency Associated with Glycemic Control in Individuals with Type 2 Diabetes Mellitus.
Συγγραφείς: Menezes-Santos M; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Santos BDC; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.; Nutrition Sciences Post-Graduation Program, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, Marcelo Deda Avenue, S/n - Jardim Rosa Elze, São Cristóvão, Sergipe, ZIP: 49107-230, Brazil., Santos RKF; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.; Health Sciences Post-Graduation Program, Department of Medicine, Center for Biological and Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., da Costa SSL; Nucleus of Competence in Oil, Gas and Biofuels - NUPEG, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Dos Santos SH; Chemistry Post-Graduation Program, Chemistry Institute, Federal University of Bahia, Salvador, Bahia, Brazil., E Silva AMO; Nutrition Sciences Post-Graduation Program, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, Marcelo Deda Avenue, S/n - Jardim Rosa Elze, São Cristóvão, Sergipe, ZIP: 49107-230, Brazil.; Health Sciences Post-Graduation Program, Department of Medicine, Center for Biological and Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Rocha VS; Department of Nutrition, Federal University of Sergipe, Lagarto, Sergipe, Brazil., Pires LV; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. lvianapires@gmail.com.; Nutrition Sciences Post-Graduation Program, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, Marcelo Deda Avenue, S/n - Jardim Rosa Elze, São Cristóvão, Sergipe, ZIP: 49107-230, Brazil. lvianapires@gmail.com.
Πηγή: Biological trace element research [Biol Trace Elem Res] 2025 Jan; Vol. 203 (1), pp. 119-126. Date of Electronic Publication: 2024 Apr 19.
Τύπος έκδοσης: Journal Article; Observational Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Imprint Name(s): Original Publication: [London, Clifton, N. J.] Humana Press.
Ιατρικοί όροι (MeSH): Diabetes Mellitus, Type 2*/blood , Copper*/blood , Copper*/deficiency, Blood Glucose/metabolism ; Blood Glucose/analysis ; Humans ; Female ; Male ; Middle Aged ; Adult ; Cross-Sectional Studies ; Glycemic Control ; Young Adult
Περίληψη: Adequate copper (Cu) status has been associated with improved glycemic control, partly because of its role in reducing oxidative stress through superoxide dismutase (SOD) activity. Thus, the aim was to investigate the relationship between plasma Cu concentration and markers associated with glycemic control in individuals with type 2 diabetes mellitus (T2DM). This observational and cross-sectional study was conducted in individuals with T2DM of both sexes, aged between 19 and 59 years. Plasma Cu levels were analyzed using inductively coupled plasma optical emission spectrometry (ICP-OES). Fasting glucose and insulin concentrations, C-peptide levels, SOD activity, and glycated hemoglobin (%HbA1c) were measured. Homeostatic model assessments (HOMA%B, HOMA%S, and HOMA-IR) were also performed. Additionally, %body fat and waist circumference were measured, and body mass index was calculated. Participants were categorized based on their plasma Cu concentrations (< 70 µg/dL and ≥ 70 µg/dL). The associations between variables were analyzed using chi-squared or Fisher's test and binary logistic regression models. Statistical significance was set at P < 0.05. Of the 97 participants (74.2% women), 85.5% had Cu deficiency. Cu-deficient individuals showed elevated C-peptide concentrations and HOMA%B values compared to those with adequate Cu levels (2.8 ng/mL vs. 1.8 ng/mL, P = 0.011; and 71.4 vs. 31.0, P = 0.003), respectively. Cu deficiency was associated with insulin resistance (P = 0.044) and decreased likelihood of exceeding the target serum glucose level (OR = 0.147, P = 0.013). However, no significant association was found between SOD activity and plasma Cu concentration. Consequently, Cu deficiency was linked to improved glycemic control, although it was not associated with the other markers.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
References: Rodacki M, Teles M, Gabbay M, Montenegro R, Bertoluci M (2023) Classificação do diabetes. Diretriz Oficial da Sociedade Brasileira de Diabetes. https://doi.org/10.29327/557753.2022-1.
Singh A, Kukreti R, Saso L, Kukreti S (2022) Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes. Molecules 27(3):950. https://doi.org/10.3390/molecules27030950. (PMID: 10.3390/molecules27030950351642158840622)
Omidian A, Pourfarzam M, Ghanadian SM, Zadhoush F (2022) Determination of plasma and erythrocyte levels of copper, magnesium, and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome. Res Pharma Sci 17(1):86–98. https://doi.org/10.4103/1735-5362.329929. (PMID: 10.4103/1735-5362.329929)
Viktorínová A, Tošerováb E, Križko M, Ďuračková Z (2009) Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metab, Clin Exp 58:1477–1482. https://doi.org/10.1016/j.metabol.2009.04.035. (PMID: 10.1016/j.metabol.2009.04.03519592053)
Festa RA, Thiele DJ (2011) Copper: an essential metal in biology. Curr Biol 21(21):R877-883. https://doi.org/10.1016/j.cub.2011.09.040. (PMID: 10.1016/j.cub.2011.09.040220754243718004)
Hasanato RM (2020) Trace elements in type 2 diabetes mellitus and their association with glycemic control. Afr Health Sci 20(1):287–293. https://doi.org/10.4314/ahs.v20i1.34. (PMID: 10.4314/ahs.v20i1.34334029177750058)
Chen MD, Lin PY, Tsou CT, Wang JJ, Lin WH (1995) Selected metals status in patients with noninsulin-dependent diabetes mellitus. Biol Trace Elem Res 50(2):119–124. https://doi.org/10.1007/BF02789414. (PMID: 10.1007/BF027894148605079)
Qiu Q, Zhang F, Zhu W, Wu J, Liang M (2016) Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 177(1):53–63. https://doi.org/10.1007/s12011-016-0877-y. (PMID: 10.1007/s12011-016-0877-y27785738)
Hordyjewska A, Popiołek Ł, Kocot J (2014) The many “faces” of copper in medicine and treatment. Biometals 27(4):611–621. https://doi.org/10.1007/s10534-014-9736-5. (PMID: 10.1007/s10534-014-9736-5247485644113679)
Marreiro D, Cruz K, Morais J, Beserra J, Severo J, de Oliveira A (2017) Zinc and oxidative stress: current mechanisms. Antioxidants 6(2):24. https://doi.org/10.3390/antiox6020024. (PMID: 10.3390/antiox6020024283536365488004)
Galhardi CM, Diniz YS, Faine LA, Rodrigues HG, Burneiko RCM, Ribas BO, Novelli ELB (2004) Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food Chem Toxicol 42(12):2053–2060. https://doi.org/10.1016/j.fct.2004.07.020. (PMID: 10.1016/j.fct.2004.07.02015500942)
Buettner GR (2011) Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem 11(4):341–346. https://doi.org/10.2174/187152011795677544. (PMID: 10.2174/187152011795677544214532423131414)
Pathak AK, Tiwari V, Kulshrestha MR, Singh S, Singh S, Singh V (2023) Impact of essential metals on insulin sensitivity and fetuin in obesity-related type 2 diabetes pathogenesis. J Diabetes Metab Disord 22(1):703–712. https://doi.org/10.1007/s40200-023-01193-6. (PMID: 10.1007/s40200-023-01193-63725583410225454)
WHO Consultation on obesity (1999: Geneva, Switzerland) & World Health Organization (2000) Obesity: preventing and managing the global epidemic: report of a WHO consultation. Available online: https://apps.who.int/iris/handle/10665/42330 . Accessed 24 Sept 2023.
World Health Organization (2008) Waist circumference and waist-hip ratio: report of a WHO expert consultation. Available online: https://www.who.int/publications/i/item/9789241501491 . Accessed 09 Dec 2023.
Ward LC (2019) Bioelectrical impedance analysis for body composition assessment: reflections on accuracy, clinical utility, and standardisation. Eur J Clin Nutr 73:194–199. (PMID: 10.1038/s41430-018-0335-330297760)
Lohman TJ, Roache AF, Martorell R (1992) Anthropometric standardization reference manual. Med Sci Sports Exerc. https://doi.org/10.1249/00005768-199208000-00020. (PMID: 10.1249/00005768-199208000-00020)
Morte ES, Barbosa I, Santos EC, Nóbrega JA, Korn M (2012) Axial view inductively coupled plasma optical emission spectrometry for monitoring tin concentration in canned tomato sauce samples. Food Chem 131:348–352. https://doi.org/10.1016/j.foodchem.2011.08.015. (PMID: 10.1016/j.foodchem.2011.08.015)
Castro JT, Santos EC, Santos WPC, Costa LM, Korn M, Nóbrega JA, Korn MGA (2009) A critical evaluation of digestion procedures for coffee samples using diluted nitric acid in closed vessels for inductively coupled plasma optical emission spectrometry. Talanta 78:1378–1382. https://doi.org/10.1016/j.talanta.2009.02.030. (PMID: 10.1016/j.talanta.2009.02.03019362204)
Santos SH, Costa SSL, Souza SO, Garcia KS, Soares SAR, Garcia CAB, Almeida TS, Araujo RGO (2021) Development of analytical method for determination of inorganic constituents in powder refreshment using dilute mineral acids and detection by ICP OES. J Braz Chem Soc 32:1361–1372. https://doi.org/10.21577/0103-5053.20210034. (PMID: 10.21577/0103-5053.20210034)
Armbruster DA, Pry T (2008) Limit of blank, limit of detection and limit of quantitation. The Clin Biochem Rev 29(Suppl 1):S49–S52 ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556583/ ). (PMID: 18852857)
Silva FV, Trevizan LC, Silva CS, Nogueira ARA, Nóbrega JA (2002) Evaluation of inductively coupled plasma optical emission spectrometers with axially and radially viewed configurations. Spectrochim Acta, Part B 57(12):1905–1913. https://doi.org/10.1016/s0584-8547(02)00176-3. (PMID: 10.1016/s0584-8547(02)00176-3)
Smith JC, Holbrook JT, Danford DE (1985) Analysis and evaluation of zinc and copper in human plasma and serum. J Am Coll Nutr 4(6):627–638. https://doi.org/10.1080/07315724.1985.10720105. (PMID: 10.1080/07315724.1985.107201054078201)
McCord JM, Fridovich I (1969) Superoxide dismutase An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244(22):6049–6055 ( https://pubmed.ncbi.nlm.nih.gov/5389100/ ). (PMID: 10.1016/S0021-9258(18)63504-55389100)
ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, Collins BS, Hilliard ME, Isaacs D, Johnson EL, Kahan S, Khunti K, Leon J, Lyons SK, Perry ML, Prahalad P, Pratley RE, Seley JJ, Stanton RC, Gabbay RA (2023) Classification and diagnosis of diabetes: standards of care in diabetes. Diabetes Care 46:S19–S40. https://doi.org/10.2337/dc23-s002. (PMID: 10.2337/dc23-s00236507649)
Levy JC, Matthews DR, Hermans MP (1998) Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21(12):2191–2192. https://doi.org/10.2337/diacare.21.12.2191. (PMID: 10.2337/diacare.21.12.21919839117)
Geloneze B, Vasques AC, Stabe CF, Pareja JC, Rosado L, Queiroz EC, Tambascia MA (2009) HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS). Arquivos Brasileiros de Endocrinol Metabol 53(2):281–287. https://doi.org/10.1590/s0004-27302009000200020. (PMID: 10.1590/s0004-27302009000200020)
Hosmer DW, Hosmer T, Lemeshow S (1980) A goodness-of-fit tests for the multiple logistic regression model. Commun Stat 10:1043–1069. https://doi.org/10.1080/03610928008827941. (PMID: 10.1080/03610928008827941)
Vejrazkova D, Vankova M, Lukasova P, Vcelak J, Bendlova B (2020) Insights into the physiology of C-peptide. Physiological research 69(Suppl 2):S237–S243. https://doi.org/10.33549/physiolres.934519. (PMID: 10.33549/physiolres.934519330946228603725)
Jones A, Hattersley A (2013) The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabetic Medicine 30(7):803–817. https://doi.org/10.1111/dme.12159. (PMID: 10.1111/dme.12159234138063748788)
Stevenson MJ, Farran IC, Uyeda KS, San Juan JA, Heffern MC (2019) Analysis of metal effects on C-peptide structure and internalization. Chembiochema: Euro J Chem Biol 20(19):2447–2453. https://doi.org/10.1002/cbic.201900172. (PMID: 10.1002/cbic.201900172)
Balsano C, Porcu C, Sideri S (2018) Is copper a new target to counteract the progression of chronic diseases? Metallomics 10(12):1712–1722. https://doi.org/10.1039/c8mt00219c. (PMID: 10.1039/c8mt00219c30339169)
Khalid M, Alkaabi J, Khan MAB, Adem A (2021) Insulin signal transduction perturbations in insulin resistance. Int J Mol Sci 22(16):8590. https://doi.org/10.3390/ijms22168590. (PMID: 10.3390/ijms22168590344453008395322)
Ikegami H, Babaya N, Noso S (2021) β-Cell failure in diabetes: common susceptibility and mechanisms shared between type 1 and type 2 diabetes. J Diab Investig 12(9):1526–1539. https://doi.org/10.1111/jdi.13576. (PMID: 10.1111/jdi.13576)
Fields M, Ferretti RJ, Smith JA, Reiser S (1984) Impairment of glucose tolerance in copper-deficient rats: dependency on the type of dietary carbohydrate. J Nutr 114(2):393–397. https://doi.org/10.1093/jn/114.2.393. (PMID: 10.1093/jn/114.2.3936363640)
Cruz KJC, de Oliveira ARS, Marreiro DDN (2015) Antioxidant role of zinc in diabetes mellitus. World J Diabetes 6(2):333–337. https://doi.org/10.4239/wjd.v6.i2.333. (PMID: 10.4239/wjd.v6.i2.333257891154360427)
Cohen AM, Miller E (1986) Effect of copper on insulin release by the intact rat pancreas and the perfused rat pancreas. Pancreas 1(4):309–316. https://doi.org/10.1097/00006676-198607000-00003. (PMID: 10.1097/00006676-198607000-000033550782)
Park L, Min D, Kim H, Park J, Choi S, Park Y (2011) The combination of metallothionein and superoxide dismutase protects pancreatic β cells from oxidative damage. Diab Metabol Res Rev 27(8):802–808. https://doi.org/10.1002/dmrr.1254. (PMID: 10.1002/dmrr.1254)
Promyos N, Phienluphon PP, Wechjakwen N, Lainampetch J, Prangthip P, Kwanbunjan K (2023) Inverse correlation of superoxide dismutase and catalase with type 2 diabetes among rural Thais. Nutrients 15(9):2071. https://doi.org/10.3390/nu15092071. (PMID: 10.3390/nu150920713743219310181415)
Bjørklund G, Dadar M, Pivina L, Doşa MD, Semenova Y, Aaseth J (2020) The role of zinc and copper in insulin resistance and diabetes mellitus. Curr Med Chem 27(39):6643–6657. https://doi.org/10.2174/0929867326666190902122155. (PMID: 10.2174/092986732666619090212215531475889)
Zheng Y, Li XK, Wang Y, Cai L (2008) The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin 32(1–2):135–145. https://doi.org/10.1080/03630260701727077. (PMID: 10.1080/0363026070172707718274991)
Yadav N, Kumar MA (2023) Interference of hemoglobin variants in HbA1c quantification. Clini Chimica acta: intlJ Clin Chem 539:55–65. https://doi.org/10.1016/j.cca.2022.11.031. (PMID: 10.1016/j.cca.2022.11.031)
Singh VP, Bali A, Singh N, Jaggi AS (2014) Advanced glycation end products and diabetic complications. KorJ Physiol Pharmacol: J Kor Physiol Soc Kor Soc Pharmacol 18(1):1–14. https://doi.org/10.4196/kjpp.2014.18.1.1. (PMID: 10.4196/kjpp.2014.18.1.1)
Basaki M, Saeb M, Nazifi S, Shamsaei H-A (2012) Zinc, copper, iron, and chromium concentrations in young patients with type 2 diabetes mellitus. Biol Trace Elem Res 148:161–164. https://doi.org/10.1007/s12011-012-9360-6. (PMID: 10.1007/s12011-012-9360-622351156)
Atari-Hajipirloo S, Valizadeh N, Khadem-Ansari MH, Rasmi Y, Kheradmand F (2016) Altered concentrations of copper, zinc, and iron are associated with increased levels of glycated hemoglobin in patients with type 2 diabetes mellitus and their first-degree relatives. Intl J Endocrinol Metabol 14(2):e33273. https://doi.org/10.5812/ijem.33273. (PMID: 10.5812/ijem.33273)
Golizeh M, Lee K, Ilchenko S, Ösme A, Bena J, Sadygov RG, Kashyap SR, Kasumov T (2017) Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes. Free Radical Biol Med 113:461–469. https://doi.org/10.1016/j.freeradbiomed.2017.10.373. (PMID: 10.1016/j.freeradbiomed.2017.10.373)
Tanaka A, Kaneto H, Miyatsuka T, Yamamoto K, Yoshiuchi K, Yamasaki Y, Shimomura I, Matsuoka TA, Matsuhisa M (2009) Role of copper ion in the pathogenesis of type 2 diabetes. Endocr J 56(5):699–706. https://doi.org/10.1507/endocrj.k09e-051. (PMID: 10.1507/endocrj.k09e-05119461160)
Cooper GJ (2011) Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer’s disease. Drugs 71(10):1281–1320. https://doi.org/10.2165/11591370-000000000-00000. (PMID: 10.2165/11591370-000000000-0000021770477)
Grant Information: Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 455117/2014-4 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Contributed Indexing: Keywords: Copper; Glycemic control; Insulin resistance; Trace element; Type 2 diabetes mellitus
Substance Nomenclature: 789U1901C5 (Copper)
0 (Blood Glucose)
Entry Date(s): Date Created: 20240419 Date Completed: 20250106 Latest Revision: 20250108
Update Code: 20260130
DOI: 10.1007/s12011-024-04185-6
PMID: 38639883
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1559-0720
DOI:10.1007/s12011-024-04185-6