Academic Journal
Electrophysiological Changes on Laryngeal Motor Neuropathways Cause Voice Disorders for Postradiotherapy Patients with Nasopharyngeal Carcinoma.
| Τίτλος: | Electrophysiological Changes on Laryngeal Motor Neuropathways Cause Voice Disorders for Postradiotherapy Patients with Nasopharyngeal Carcinoma. |
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| Συγγραφείς: | He C; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China; Department of Otolaryngology Head and Neck Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Guo L; Department of Oncology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Zheng M; Department of Otolaryngology Head and Neck Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Peng H; Department of Otolaryngology Head and Neck Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: doctorpenghong@163.com., Zhang X; Department of Oncology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Fan C; Department of Psychiatry, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Zhao X; Department of Otolaryngology Head and Neck Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Gong P; Department of Otolaryngology Head and Neck Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Deng Z; Department of Otolaryngology Head and Neck Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Xu G; Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Chen C; Department of Psychiatry, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China. |
| Πηγή: | Journal of voice : official journal of the Voice Foundation [J Voice] 2026 Sep; Vol. 40 (5), pp. 1431-1439. Date of Electronic Publication: 2024 Apr 16. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mosby Country of Publication: United States NLM ID: 8712262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4588 (Electronic) Linking ISSN: 08921997 NLM ISO Abbreviation: J Voice Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : St. Louis, MO : Mosby Original Publication: [New York, N.Y.] : Raven Press, 1987- |
| Ιατρικοί όροι (MeSH): | Nasopharyngeal Carcinoma*/radiotherapy , Nasopharyngeal Neoplasms*/radiotherapy , Voice Disorders*/physiopathology , Voice Disorders*/etiology , Voice Disorders*/diagnosis , Radiation Injuries*/physiopathology , Radiation Injuries*/etiology , Radiation Injuries*/diagnosis , Voice Quality*/radiation effects , Carcinoma*/radiotherapy , Laryngeal Nerves*/physiopathology , Laryngeal Nerves*/radiation effects , Motor Cortex*/physiopathology , Motor Cortex*/radiation effects, Humans ; Female ; Male ; Middle Aged ; Electromyography ; Prospective Studies ; Adult ; Case-Control Studies ; Transcranial Magnetic Stimulation ; Time Factors ; Evoked Potentials, Motor ; Risk Factors |
| Περίληψη: | Objective: This study explored electrophysiological changes in the laryngeal motor neuropathway and determined whether lesions in the laryngeal motor cortex (LMC) and its descending tract contribute to voice deterioration and peripheral nerve palsy in patients with nasopharyngeal carcinoma (NPC) postradiotherapy (RT). Study Designs: Prospective cohort study. Methods: Twenty-two patients with NPC at 2 to 4years post-RT (8 female and 14 male), 22 patients with NPC at 8 to 10years post-RT (8 female and 14 male), and 22 healthy individuals (9 female and 13 male) were selected to test their magnetic evoked potentials (MEP), motor nerve conduction, and voice quality using transcranial magnetic stimulation, laryngeal electromyography, and the XION DiVAS acoustic analysis software. Three groups were matched according to approximate age. Multiple comparisons were performed among the three groups. Results: The voice quality of post-RT patients with NPC deteriorated compared to that of healthy individuals. Bilateral LMC and their corticonuclear tracts to the bilateral ambiguous nuclei of post-RT patients with NPC were impaired according to multigroup comparisons of MEP amplitudes, latencies, and resting motor thresholds. The vagus and recurrent laryngeal nerves (RLN) of post-RT patients with NPC were impaired according to multigroup comparisons of the amplitude and latencies of the compound muscle action potential and latencies of f-waves. Conclusions: The voice quality of patients with NPC deteriorated after RT. The pathogenesis of post-RT voice deterioration may involve radiation-induced injuries to the vagus, RLN, and bilateral LMC. Furthermore, radiation-induced injuries to the bilateral LMC may contribute to vagus and RLN palsies. These findings support the use of transcranial approaches to treating voice disorders and peripheral nerve palsies in post-RT patients with NPC. Trial Registration: ChiCTR2100054425; Electrophysiological Study of Vocal-Fold Mobility Disorders After Radiotherapy for NPC Patients via Magnetic Evoked Potential and Their Correlation with Voice Quality Assessment; https://www.chictr.org.cn/bin/project/edit?pid=144429. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors have declared that no competing financial or non-financial interests existed at the time of publication. |
| Contributed Indexing: | Keywords: Laryngeal electromyography; Laryngeal motor cortex; Magnetic evoked potential; Nasopharyngeal carcinoma; Radiotherapy; Voice disorder |
| Entry Date(s): | Date Created: 20240417 Date Completed: 20260907 Latest Revision: 20260907 |
| Update Code: | 20260908 |
| DOI: | 10.1016/j.jvoice.2024.03.037 |
| PMID: | 38631941 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-4588 |
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| DOI: | 10.1016/j.jvoice.2024.03.037 |