Academic Journal
Leveraging meta-regression to test if medication effects on cue-induced craving are associated with clinical efficacy.
| Τίτλος: | Leveraging meta-regression to test if medication effects on cue-induced craving are associated with clinical efficacy. |
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| Συγγραφείς: | Nieto SJ; Department of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA. snieto@psych.ucla.edu., Du H; Department of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA., Meredith LR; Department of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA., Donato S; Department of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA., Magill M; Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, Rhode Island, USA., Ray LA; Department of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA. |
| Πηγή: | Psychopharmacology [Psychopharmacology (Berl)] 2024 Aug; Vol. 241 (8), pp. 1679-1689. Date of Electronic Publication: 2024 Apr 13. |
| Τύπος έκδοσης: | Journal Article; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer-Verlag. |
| Ιατρικοί όροι (MeSH): | Craving*/drug effects , Alcoholism*/drug therapy , Alcoholism*/psychology , Cues* , Randomized Controlled Trials as Topic*, Alcohol Drinking/psychology ; Humans ; Treatment Outcome |
| Περίληψη: | Rationale: The alcohol cue exposure paradigm is a common method for evaluating new treatments for alcohol use disorder (AUD); however, it is unclear if medication-related reductions in cue-induced craving in the human laboratory can predict the clinical success of those medications in reducing alcohol consumption during clinical trials. Objectives: To use a novel meta-analytic approach to test whether medication effect sizes on cue-induced alcohol craving are associated with clinical efficacy in clinical trials. Method: We searched the literature for medications tested for AUD treatment using both the alcohol cue-reactivity paradigm and randomized clinical trials (RCTs). For alcohol cue-reactivity studies, we computed medication effect sizes for cue-induced alcohol craving (k = 36 studies, 15 medications). For RCTs, we calculated medication effect sizes for heavy drinking and abstinence (k = 139 studies, 19 medications). Using medication as the unit of analysis, we applied the Williamson-York bivariate weighted least squares estimation to account for errors in both independent and dependent variables. We also conducted leave-one-out cross validation simulations to examine the predictive utility of cue-craving medication effect sizes on RCT heavy drinking and abstinence endpoints. Results: There was no significant relationship between medication effects on cue-induced alcohol craving in the human laboratory and medication effects on heavy drinking ( INLINEMATH = 0.253, SE = 0.189, p = 0.090) and abstinence ( INLINEMATH = 0.829, SE = 0.747, p = 0.133) in RCTs. Conclusions: The preliminary results of the current study challenge the assumption that alcohol cue-reactivity alone can be used as an early efficacy indicator for AUD pharmacotherapy development. These findings suggest that a wider range of early efficacy indicators and experimental paradigms be considered for Phase II testing of novel compounds. (© 2024. The Author(s).) |
| References: | Control Clin Trials. 1986 Sep;7(3):177-88. (PMID: 3802833) Addict Biol. 2014 Sep;19(5):941-54. (PMID: 23489253) Alcohol Clin Exp Res. 1999 Aug;23(8):1386-94. (PMID: 10470982) J Abnorm Psychol. 1987 May;96(2):122-6. (PMID: 3584660) Curr Top Behav Neurosci. 2016;28:151-71. (PMID: 27240677) Curr Pharm Des. 2010;16(19):2149-58. (PMID: 20482505) Alcohol Clin Exp Res. 2012 Feb;36(2):351-60. (PMID: 21919922) Alcohol Clin Exp Res (Hoboken). 2023 Sep;47(9):1629-1645. (PMID: 37423771) Psychopharmacology (Berl). 2023 Sep;240(9):1921-1930. (PMID: 37452887) Neuropsychopharmacology. 2021 Feb;46(3):519-527. (PMID: 33235284) Psychopharmacology (Berl). 2011 Oct;217(3):341-51. (PMID: 21487653) Psychopharmacology (Berl). 2017 Sep;234(18):2737-2745. (PMID: 28600734) Psychopharmacology (Berl). 2002 Feb;160(1):19-29. (PMID: 11862370) Psychopharmacology (Berl). 2001 Apr;155(1):27-34. (PMID: 11374333) Handb Exp Pharmacol. 2018;248:537-578. (PMID: 29374834) Alcohol Clin Exp Res. 2020 Jan;44(1):23-35. (PMID: 31803968) Addict Biol. 2017 May;22(3):581-615. (PMID: 26833803) Perspect Psychol Sci. 2016 Sep;11(5):713-729. (PMID: 27694466) Am J Psychiatry. 2003 Jul;160(7):1320-5. (PMID: 12832248) Addiction. 1999 Mar;94(3):327-40. (PMID: 10605857) Alcohol Clin Exp Res. 2020 Jul;44(7):1431-1443. (PMID: 32363592) Alcohol Clin Exp Res. 2012 Jun;36(6):972-83. (PMID: 22309888) Psychon Bull Rev. 2026 Feb 27;33(3):. (PMID: 41760983) J Consult Clin Psychol. 2013 Feb;81(1):13-22. (PMID: 23231573) Psychopharmacology (Berl). 2009 Jul;205(1):53-62. (PMID: 19319508) J Addict Med. 2022 Nov-Dec 01;16(6):630-638. (PMID: 35653782) Alcohol Clin Exp Res. 2014 Jan;38(1):27-32. (PMID: 23889161) Addict Biol. 2012 May;17(3):513-27. (PMID: 22458728) J Subst Abuse Treat. 2022 Jul;138:108749. (PMID: 35216868) |
| Grant Information: | F31AA029295 United States AA NIAAA NIH HHS; F32 AA029288 United States AA NIAAA NIH HHS; F32AA029288 United States AA NIAAA NIH HHS; R21 AA029771 United States AA NIAAA NIH HHS; K24 AA025704 United States AA NIAAA NIH HHS; R21AA029771 United States AA NIAAA NIH HHS; F31 AA029295 United States AA NIAAA NIH HHS; K24AA025704 United States AA NIAAA NIH HHS |
| Contributed Indexing: | Keywords: Alcohol cue-reactivity; Alcohol use disorder; Cue-induced craving; Human laboratory; Medication development; Randomized clinical trials |
| Entry Date(s): | Date Created: 20240413 Date Completed: 20240724 Latest Revision: 20260924 |
| Update Code: | 20260924 |
| PubMed Central ID: | PMC11269462 |
| DOI: | 10.1007/s00213-024-06589-7 |
| PMID: | 38613685 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1432-2072 |
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| DOI: | 10.1007/s00213-024-06589-7 |