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α1,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: α1,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation.
Συγγραφείς: Al-Amoodi AS; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Kai J; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Li Y; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Malki JS; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Alghamdi A; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Al-Ghuneim A; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Saera-Vila A; Sequentia Biotech SL, Barcelona, Spain., Habuchi S; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Merzaban JS; Bioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.; KAUST Smart-Health Initiative, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Πηγή: IScience [iScience] 2024 Jan 12; Vol. 27 (2), pp. 108882. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: [Cambridge, MA] : Cell Press, [2018]-
Περίληψη: For almost two decades, clinicians have overlooked the diagnostic potential of CD34neg hematopoietic stem cells because of their limited homing capacity relative to CD34posHSCs when injected intravenously. This has contributed to the lack of appeal of using umbilical cord blood in HSC transplantation because its stem cell count is lower than bone marrow. The present study reveals that the homing and engraftment of CD34negHSCs can be improved by adding the Sialyl Lewis X molecule via α1,3-fucosylation. This unlocks the potential for using this more primitive stem cell to treat blood disorders because our findings show CD34negHSCs have the capacity to regenerate cells in the bone marrow of mice for several months. Furthermore, our RNA sequencing analysis revealed that CD34negHSCs have unique adhesion pathways, downregulated in CD34posHSCs, that facilitate interaction with the bone marrow niche. Our findings suggest that CD34neg cells will best thrive when the HSC resides in its microenvironment.
(© 2024 The Author(s).)
Competing Interests: The authors declare no competing interests.
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Contributed Indexing: Keywords: Immunology; Stem cells research; Transcriptomics
Entry Date(s): Date Created: 20240207 Latest Revision: 20240210
Update Code: 20260130
PubMed Central ID: PMC10845921
DOI: 10.1016/j.isci.2024.108882
PMID: 38322982
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2589-0042
DOI:10.1016/j.isci.2024.108882