Academic Journal
Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber.
| Τίτλος: | Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber. |
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| Συγγραφείς: | Azimi S; School of Mechatronic Systems Engineering, Simon Fraser University, 250 - 13450 102nd Avenue, Surrey, BC V3T 0A3, Canada., Arzanpour S; School of Mechatronic Systems Engineering, Simon Fraser University, Room 4174, 250 - 13450 102nd Avenue, Surrey, BC V3T 0A3, Canada. |
| Πηγή: | Journal of biomechanical engineering [J Biomech Eng] 2024 Apr 01; Vol. 146 (4). |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Society Of Mechanical Engineers Country of Publication: United States NLM ID: 7909584 Publication Model: Print Cited Medium: Internet ISSN: 1528-8951 (Electronic) Linking ISSN: 01480731 NLM ISO Abbreviation: J Biomech Eng Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : American Society Of Mechanical Engineers Original Publication: [New York] American Society of Mechanical Engineers. |
| Ιατρικοί όροι (MeSH): | Inhalation Spacers* , Metered Dose Inhalers*, Reproducibility of Results ; Equipment Design ; Aerosols ; Drug Delivery Systems ; Particle Size |
| Περίληψη: | This paper presents an innovative approach to the design optimization of valved holding chambers (VHCs), crucial devices for aerosol drug delivery. We present the design of an optimal cylindrical VHC body and introduce a novel valve based on particle impaction theory. The research combines computational simulations and physical experiments to assess the performance of various VHCs, with a special focus on the deposition patterns of medication particles within these devices. The methodology incorporates both experimental and simulation approaches to validate the reliability of the simulation. Emphasis is placed on the deposition patterns observed on the VHC walls and the classification of fine and large particles for salbutamol sulfate particles. The study reveals the superior efficacy of our valve design in separating particles compared to commercially available VHCs. In standard conditions, our valve design allows over 95% of particles under 7 μm to pass through while effectively filtering those larger than 8 μm. The optimized body design accomplishes a 60% particle mass flow fraction at the outlet and an average particle size reduction of 58.5%. When compared numerically in terms of size reduction, the optimal design outperforms the two commercially available VHCs selected. This study provides valuable insights into the optimization of VHC design, offering significant potential for improved aerosol drug delivery. Our findings demonstrate a new path forward for future studies, aiming to further optimize the design and performance of VHCs for enhanced pulmonary drug delivery. (Copyright © 2024 by ASME.) |
| Grant Information: | General Natural Sciences and Engineering Research Council of Canada |
| Contributed Indexing: | Keywords: ANSYS; CFD; COPD; asthma; inhalation therapy; optimization; spacer; valved holding chamber (VHC) |
| Substance Nomenclature: | 0 (Aerosols) |
| Entry Date(s): | Date Created: 20240106 Date Completed: 20240208 Latest Revision: 20240618 |
| Update Code: | 20260130 |
| DOI: | 10.1115/1.4064436 |
| PMID: | 38183225 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1528-8951 |
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| DOI: | 10.1115/1.4064436 |